公开(公告)号：AU2020204037A1

公开(公告)日：2020-07-09

申请号：AU2020204037

申请日：2020-06-17

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KAKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

Abstract: [00464] Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5 yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4 oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.