公开(公告)号：SMT202500078T1

公开(公告)日：2025-03-12

申请号：SMT202500078

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

公开(公告)号：DK3470063T3

公开(公告)日：2025-01-20

申请号：DK18192504

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61P11/00 ,  A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：RS57831B1

公开(公告)日：2018-12-31

申请号：RSP20181318

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：AU2020204037A1

公开(公告)日：2020-07-09

申请号：AU2020204037

申请日：2020-06-17

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KAKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

Abstract: [00464] Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5 yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4 oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

公开(公告)号：AU2018229528A1

公开(公告)日：2018-10-11

申请号：AU2018229528

申请日：2018-09-14

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-y) benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1 H-quinoline-3 carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

公开(公告)号：SG11201503365YA

公开(公告)日：2015-06-29

申请号：SG11201503365Y

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

公开(公告)号：CA2890106A1

公开(公告)日：2014-05-08

申请号：CA2890106

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

公开(公告)号：PL3470063T3

公开(公告)日：2025-04-14

申请号：PL18192504

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61P11/00 ,  A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：HRP20250100T1

公开(公告)日：2025-03-28

申请号：HRP20250100

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61P11/00 ,  A61K9/20 ,  A61K31/443 ,  A61K31/47 ,  A61K45/06

公开(公告)号：SI2914248T1

公开(公告)日：2018-12-31

申请号：SI201331163

申请日：2013-11-01

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  KARKARE RADHIKA ,  MOORE MICHAEL DOUGLAS

IPC: A61K9/00 ,  A61K31/00 ,  A61K45/00