公开(公告)号：AU2010216219A1

公开(公告)日：2011-09-01

申请号：AU2010216219

申请日：2010-02-16

Applicant: VERTEX PHARMA

Inventor： ALEX ARONOV ,  KEERTHI BANDARAGE UPUL ,  KEVIN COTTRELL ,  ROBERT DAVIES ,  ELAINE KRUEGER ,  MARK LEDEBOER ,  BRIAN LEDFORD ,  ARNAUD LE TIRAN ,  YUSHENG LIAO ,  DAVID MESSERSMITH ,  TIANSHENG WANG ,  JINWANG XU

IPC: C07D513/04 ,  A61K31/4365 ,  A61P25/00

Abstract: The present invention relates to compounds (I) useful as inhibitors of PBK, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AU2010250055A1

公开(公告)日：2011-09-15

申请号：AU2010250055

申请日：2010-02-25

Applicant: VERTEX PHARMA

Inventor： ALEX ARONOV ,  JON COME ,  KEVIN COTTRELL ,  RONALD GREY ,  AMAUD LE TIRAN ,  VALERIE MARONE ,  GABRIEL MARTINEZ-BOTELLA ,  DAVID MESSERSMITH ,  PORTER HUCK EMILIE

IPC: C07D417/04 ,  A61K31/4427 ,  A61K31/4965 ,  A61K31/501 ,  A61K31/506 ,  A61P29/00 ,  A61P37/00 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of P13K, particularly of P13Kgamma. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of several diseases, such as cancer and autoimmune diseases.