公开(公告)号：ZA200609975B

公开(公告)日：2008-02-27

申请号：ZA200609975

申请日：2005-05-13

Applicant: VERTEX PHARMA

Inventor： GABRIEL MARTINEZ-BOTELLA ,  HALE MICHAEL R ,  OIS MALTAIS FRAN ,  QING TANG ,  JUDITH STRAUB

IPC: A61K20090101 ,  A61K31/4439 ,  A61P20090101 ,  A61P9/00 ,  A61P25/00 ,  A61P37/00 ,  C07D20090101 ,  C07D401/04 ,  C07F20090101 ,  C07F9/58 ,  C07F9/6558

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：ZA200802685B

公开(公告)日：2009-10-28

申请号：ZA200802685

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： FRANCESCO SALITURO ,  LUC FARMER ,  TIANSHENG WANG ,  JIAN WANG ,  RANDY BETHIEL ,  MARION WANNAMAKER ,  GABRIEL MARTINEZ-BOTELLA ,  JOHN DUFFY ,  ALEXANDER ARONOV ,  DAVID LAUFFER ,  ALBERT PIERCE

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorder.

公开(公告)号：AU2010250055A1

公开(公告)日：2011-09-15

申请号：AU2010250055

申请日：2010-02-25

Applicant: VERTEX PHARMA

Inventor： ALEX ARONOV ,  JON COME ,  KEVIN COTTRELL ,  RONALD GREY ,  AMAUD LE TIRAN ,  VALERIE MARONE ,  GABRIEL MARTINEZ-BOTELLA ,  DAVID MESSERSMITH ,  PORTER HUCK EMILIE

IPC: C07D417/04 ,  A61K31/4427 ,  A61K31/4965 ,  A61K31/501 ,  A61K31/506 ,  A61P29/00 ,  A61P37/00 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of P13K, particularly of P13Kgamma. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of several diseases, such as cancer and autoimmune diseases.

公开(公告)号：ZA200710379B

公开(公告)日：2009-05-27

申请号：ZA200710379

申请日：2006-05-22

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK W ,  WANNAMAKER MARION W ,  FARMER LUC J ,  TIANSHENG WANG ,  PIERCE ALBERT C ,  GABRIEL MARTINEZ-BOTELLA ,  BETHIEL RANDY S ,  BEMIS GUY W ,  JIAN WANG ,  SALITURO FRANCESCO G ,  ARNOST MICHAEL J ,  COME JON H ,  JEREMY GREEN ,  MICHELLE STEWART ,  CRAIG MARHEFKA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to compounds of formula (I) wherein Q, Z, R 1 , R 2 , and R 3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：ZA200610163B

公开(公告)日：2008-02-27

申请号：ZA200610163

申请日：2005-05-13

Applicant: VERTEX PHARMA

Inventor： GABRIEL MARTINEZ-BOTELLA ,  HALE MICHAEL R ,  FRANCOIS MALTAIS ,  QING TANG ,  JUDITH STRAUB

IPC: A61K20090101 ,  A61K31/506 ,  A61P20090101 ,  A61P35/00 ,  C07D20090101 ,  C07D403/04

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：PT3305776T

公开(公告)日：2019-12-17

申请号：PT17184079

申请日：2005-05-13

Applicant: VERTEX PHARMA

Inventor： MICHAEL R HALE ,  FRANCOIS MALTAIS ,  QING TANG ,  GABRIEL MARTINEZ-BOTELLA ,  JUDITH STRAUB

IPC: C07D401/04 ,  A61K31/4439 ,  A61P9/00 ,  A61P25/00 ,  A61P37/00 ,  C07F9/58 ,  C07F9/6558

公开(公告)号：ZA200710332B

公开(公告)日：2009-03-25

申请号：ZA200710332

申请日：2006-05-12

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  NICOLE ZIMMERMANN ,  LEANNE KNOLL TARA ,  GABRIEL MARTINEZ-BOTELLA ,  ESTHER MARTINBOROUGH

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.