公开(公告)号：IN885KON2014A

公开(公告)日：2015-10-02

申请号：IN885KON2014

申请日：2014-04-23

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM R ,  LITTLER BENJAMIN JOSEPH ,  CHOUDHURY ANUSUYA ,  HARRISON CRISTIAN L ,  VELURI RAVIKANTH ,  RYAN MICHAEL P ,  JIANG LICONG ,  LUSS LUSIS EDUARD

IPC: C07D405/12 ,  C07D405/14 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof are useful as modulators of ATP Binding Cassette ('ABC') transporters or fragments thereof including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.