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公开(公告)号：KR20180043408A
公开(公告)日：2018-04-27
申请号：KR20187011145
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/4704 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/56
CPC classification number: C07C205/43 , C07C68/02 , C07C69/96 , C07C201/08 , C07C213/02 , C07C229/66 , C07D215/233 , C07D215/56 , G01N33/5041 , G01N33/6872 , Y02P20/55
Abstract: 본발명은하기화학식 2의카르복실산을커플링제의존재하에하기화학식 3의아닐린과커플링시키는것을포함하는, 하기화학식 1의화합물의제조방법을제공한다.
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2.发明申请PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES 审中-公开生产苯基-6-（1-（苯基）尿嘧啶）的方法NICOTINAMIDES
公开(公告)号：WO2010093890A3
公开(公告)日：2010-12-16
申请号：PCT/US2010024054
申请日：2010-02-12
Applicant: VERTEX PHARMA , ROEPER STEFANIE , LOOKER ADAM R , MARTINOT THEODORE A , NEUBERT-LANGILLE BOBBIANNA , RYAN MICHAEL P , SNOONIAN JOHN R
Inventor： ROEPER STEFANIE , LOOKER ADAM R , MARTINOT THEODORE A , NEUBERT-LANGILLE BOBBIANNA , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
CPC classification number: C07D213/80 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
Abstract translation: 本发明涉及制备可用作p38激酶抑制剂的化合物的方法。 本发明的方法适用于大规模制备，并以高纯度产生稳定的苯基-6-（1-（苯基）脲基）烟酰胺。
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3.发明专利
公开(公告)号：MX384179B
公开(公告)日：2025-03-14
申请号：MX2018015576
申请日：2011-09-20
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , KRUEGER BRIAN R , YAP DAHRIKA MILFRED LAO , VAN GOOR FREDRICK F , ZLOKARNIK GREGOR , DEMATTEI JOHN , TRUDEAU MARTIN , BOTFIELD MARTYN C , RYAN MICHAEL P , GROOTENHUIS PETER D J , ROEPER STEFANIE
IPC: C07D215/233 , A61P1/00 , A61P1/10 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/02 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/00 , A61P5/10 , A61P5/16 , A61P5/18 , A61P5/48 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/10 , A61P7/12 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/08 , A61P15/10 , A61P17/00 , A61P19/08 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/04 , A61P31/10 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07C201/08 , C07C229/66 , C07D215/56
Abstract: La invención proporciona un proceso para la preparación de un compuesto de la Fórmula 1 (ver Fórmula) que comprende acoplar un ácido carboxílico de la Fórmula 2 (ver Fórmula) con una anilina de la Fórmula 3 (ver Fórmula) en presencia de un agente de acoplamiento.
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公开(公告)号：CA2984994C
公开(公告)日：2020-03-31
申请号：CA2984994
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/56
Abstract: The invention provides a process for the preparation of a compound of Formula 1; (See Formula 1) comprising coupling a carboxylic acid of Formula 2; (See Formula 2) with an aniline of Formula 3; (See Formula 3) in the presence of a coupling agent.
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Patent Agency Ranking
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公开(公告)号：AU2012335714A1
公开(公告)日：2014-05-22
申请号：AU2012335714
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN L , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D405/12 , A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/14 , C07D498/04
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2018204671B2
公开(公告)日：2019-05-02
申请号：AU2018204671
申请日：2018-06-27
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR , DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA J , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP GUERETTE DAHRIKA MILFRED LAO , KRUEGER BRIAN R
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.
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公开(公告)号：SI2776427T1
公开(公告)日：2017-05-31
申请号：SI201230931
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D405/00 , A61K31/00 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D498/00
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公开(公告)号：AU2012335714B2
公开(公告)日：2017-04-13
申请号：AU2012335714
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN L , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS-LUSIS EDUARD
IPC: C07D405/12 , A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/14 , C07D498/04
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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