公开(公告)号：AU2023218940A1

公开(公告)日：2024-08-22

申请号：AU2023218940

申请日：2023-02-08

Applicant: VERTEX PHARMA

Inventor： SENTER TIMOTHY J ,  CHEN MING ,  DAKIN LESLIE A ,  GALE-DAY ZACHARY ,  NAMIREMBE SHEILA ,  OLSEN JESSICA H ,  SHIMIZU AKIRA J ,  WANG HAOXUAN ,  WANG TIANSHENG

IPC: C07D401/06 ,  A61K31/438 ,  A61K31/444 ,  A61K31/506 ,  A61P13/12 ,  A61P35/00 ,  C07D401/14 ,  C07D471/10 ,  C07D491/107 ,  C07D495/10 ,  C07D519/00

Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).