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公开(公告)号：WO03038442A3
公开(公告)日：2003-10-09
申请号：PCT/US0234512
申请日：2002-10-29
Applicant: VERTEX PHARMA , VAN DRIE JOHN H , PENG JEFFREY W
Inventor： VAN DRIE JOHN H , PENG JEFFREY W
CPC classification number: G06F19/706 , G06F19/16
Abstract: The present invention relates to processes for producing an optimized pharmacophore for a target protein. The present invention also relates to processes for identifying compounds having an affinity to a target protein. The present invention also relates to processes for designing a ligand for a target protein using the optimized pharmacophore of the present invention. The present invention also provides a computer for use in designing a ligand for a target protein using the optimized pharmacophore of the present invention.
Abstract translation: 本发明涉及生产用于靶蛋白的优化的药效团的方法。 本发明还涉及鉴定对靶蛋白具有亲和性的化合物的方法。 本发明还涉及使用本发明的优化的药效团设计靶蛋白的配体的方法。 本发明还提供了一种计算机，用于使用本发明的优化的药效团设计靶蛋白的配体。
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2.发明申请NOE-NMR BASED METHODS FOR THE IDENTIFYCATION OF COMPOUNDS WHICH CAN BIND TO MEMBRANE RECEPTORS 审中-公开用于识别化合物的基于NO-NMR的方法，其可以结合到膜受体上
公开(公告)号：WO03038443A3
公开(公告)日：2003-09-18
申请号：PCT/US0234831
申请日：2002-10-30
Applicant: VERTEX PHARMA , BOTFIELD MARTYN , PENG JEFFREY W
Inventor： BOTFIELD MARTYN , PENG JEFFREY W
IPC: G01N24/12 , C12P21/04 , G01N33/566 , G01R33/465 , G06F19/00 , G06F19/16 , G06F19/18 , G06F17/00
CPC classification number: G06F19/16 , G01N33/566 , G01N2500/00 , G01N2500/04 , G06F19/18 , G06F19/70
Abstract: The present invention relates to methods of identifying compounds that can bind to a membrane-bound receptor by means of Nuclear Overheuser Effect NMR data. These data are collected on complexes of the receptor and a know (or potential) receptor ligand, the receptors being incorporated in virus-Like particles.
Abstract translation: 本发明涉及通过核过热器效应NMR数据鉴定可结合膜结合受体的化合物的方法。 这些数据收集在受体和知道（或潜在）受体配体的复合物上，受体被并入病毒样颗粒中。
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3.发明专利
公开(公告)号：AU2002359332A1
公开(公告)日：2003-05-12
申请号：AU2002359332
申请日：2002-10-30
Applicant: VERTEX PHARMA
Inventor： BOTFIELD MARTYN , PENG JEFFREY W
IPC: G01N24/12 , C12P21/04 , G01N33/566 , G01R33/465 , G06F19/00 , G06F19/16 , G06F19/18 , G06F17/00
Abstract: The present invention relates to methods of identifying compounds that can bind to a membrane-bound receptor.
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公开(公告)号：AU2002356864A1
公开(公告)日：2003-05-12
申请号：AU2002356864
申请日：2002-10-29
Applicant: VERTEX PHARMA
Inventor： DRIE JOHN H VAN , PENG JEFFREY W
Abstract: The present invention relates to processes for producing an optimized pharmacophore for a target protein. The present invention also relates to processes for identifying compounds having an affinity to a target protein. The present invention also relates to processes for designing a ligand for a target protein using the optimized pharmacophore of the present invention. The present invention also provides a computer for use in designing a ligand for a target protein using the optimized pharmacophore of the present invention.
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