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1.发明申请PHARMACEUTICAL COMPOSITION OF N- [2,4-BIS (1, 1 -DIMETHYLETHYL) - 5 - HYDROXYPHENYL] - 1, 4 - DIHYDRO - 4 - OXOQUINOLINE - 3 - CARBOXAMIDE AND ADMINISTRATION THEREOF 审中-公开N- [2,4-BIS（1,1-二甲基）-5-羟基苯基] -1,4-二氢-4-氧杂喹啉-3-羧酰胺的药物组合物及其施用方法
公开(公告)号：WO2010019239A3
公开(公告)日：2011-05-26
申请号：PCT/US2009004629
申请日：2009-08-13
Applicant: VERTEX PHARMA , ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
CPC classification number: A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
Abstract translation: 本发明涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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2.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂
公开(公告)号：WO2010048526A3
公开(公告)日：2010-09-16
申请号：PCT/US2009061882
申请日：2009-10-23
Applicant: VERTEX PHARMA , BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
Inventor： BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
IPC: C07D451/02 , A61K31/439 , A61P11/00
CPC classification number: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1856 , G01N33/5041 , G01N33/6872 , G01N2800/382
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:
Abstract translation: 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。 （升）; 或其药学上可接受的盐，其中：环A选自：
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公开(公告)号：WO2005019832A2
公开(公告)日：2005-03-03
申请号：PCT/US2004027524
申请日：2004-08-23
Applicant: VERTEX PHARMA , BOTFIELD MARTYN , FRIEDMAN DAVID
Inventor： BOTFIELD MARTYN , FRIEDMAN DAVID
CPC classification number: C40B30/04 , C12Q1/485 , G01N33/6812 , G01N33/6842 , G01N33/6848 , G01N2458/15 , G01N2500/00
Abstract: The invention provides methods and compositions for analyzing modification-mediated signaling pathways.
Abstract translation: 本发明提供了用于分析修饰介导的信号传导途径的方法和组合物。
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4.发明申请NOE-NMR BASED METHODS FOR THE IDENTIFYCATION OF COMPOUNDS WHICH CAN BIND TO MEMBRANE RECEPTORS 审中-公开用于识别化合物的基于NO-NMR的方法，其可以结合到膜受体上
公开(公告)号：WO03038443A3
公开(公告)日：2003-09-18
申请号：PCT/US0234831
申请日：2002-10-30
Applicant: VERTEX PHARMA , BOTFIELD MARTYN , PENG JEFFREY W
Inventor： BOTFIELD MARTYN , PENG JEFFREY W
IPC: G01N24/12 , C12P21/04 , G01N33/566 , G01R33/465 , G06F19/00 , G06F19/16 , G06F19/18 , G06F17/00
CPC classification number: G06F19/16 , G01N33/566 , G01N2500/00 , G01N2500/04 , G06F19/18 , G06F19/70
Abstract: The present invention relates to methods of identifying compounds that can bind to a membrane-bound receptor by means of Nuclear Overheuser Effect NMR data. These data are collected on complexes of the receptor and a know (or potential) receptor ligand, the receptors being incorporated in virus-Like particles.
Abstract translation: 本发明涉及通过核过热器效应NMR数据鉴定可结合膜结合受体的化合物的方法。 这些数据收集在受体和知道（或潜在）受体配体的复合物上，受体被并入病毒样颗粒中。
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5.发明申请ACYLIC PIPERAZINE AND PIPERIDINE DERIVATIVES WHICH ARE USEFUL FOR TREATING NEURONAL DAMAGE 审中-公开可用于治疗神经损伤的ACYLIC PIPERAZINE AND PIPERIDINE DERIVATIVES
公开(公告)号：WO02102381A9
公开(公告)日：2003-03-06
申请号：PCT/US0218999
申请日：2002-06-13
Applicant: VERTEX PHARMA , LAUFFER DAVID , TOMLINSON RONALD , OTTOW ECKARD , BOTFIELD MARTYN
Inventor： LAUFFER DAVID , TOMLINSON RONALD , OTTOW ECKARD , BOTFIELD MARTYN
IPC: C07D295/18 , A61K31/445 , A61K31/495 , A61K45/00 , A61P3/10 , A61P9/10 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/30 , A61P43/00 , C07B61/00 , C07D211/16 , C07D295/185 , C07D241/04
CPC classification number: C07D295/185 , C07D211/16 , C40B40/00
Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
Abstract translation: 本发明涉及无环哌嗪和哌啶衍生物，其特别可用于治疗或预防神经元损伤，特别是与神经疾病相关的损伤。 这些化合物也可用于刺激神经生长。 本发明还提供包含本发明化合物的组合物和利用这些组合物治疗或预防神经元损伤或刺激神经生长的方法。
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Patent Agency Ranking
公开(公告)号：EP1766091A4
公开(公告)日：2009-03-18
申请号：EP05804844
申请日：2005-05-27
Applicant: VERTEX PHARMA
Inventor： JAIN-PANDEY JUGNU , HARDING MATTHEW W , RAMACHANDRAN RAVI , BOTFIELD MARTYN
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
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公开(公告)号：HUE053357T2
公开(公告)日：2021-06-28
申请号：HUE17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：LT3345625T
公开(公告)日：2021-02-10
申请号：LT17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：CY1121572T1
公开(公告)日：2020-05-29
申请号：CY191100385
申请日：2019-04-08
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: ΗπαρούσαεφεύρεσηαφοράσεφαρμακευτικέςσυνθέσειςπουπεριλαμβάνουνδιασποράστερεούτουΝ-[2,4-Δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3 καρβοξαμιδίου, μεθόδουςβιομηχανικήςκατασκευήςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσηςκαιμεθόδουςχορήγησηςφαρμακευτικώνσυνθέσεωντηςπαρούσαςεφεύρεσης.
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公开(公告)号：SI2464337T1
公开(公告)日：2019-05-31
申请号：SI201031871
申请日：2010-02-18
Applicant: VERTEX PHARMA
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