公开(公告)号：WO1996028088A3

公开(公告)日：1996-09-19

申请号：PCT/US1996003092

申请日：1996-03-08

Applicant: VNUS MEDICAL TECHNOLOGIES, INC.

Inventor： VNUS MEDICAL TECHNOLOGIES, INC. ,  LAUFER, Michael, D. ,  MILLER, Gary, H.

IPC: A61B05/026

公开(公告)号：WO1997039688A2

公开(公告)日：1997-10-30

申请号：PCT/US1997006597

申请日：1997-04-21

Applicant: VNUS MEDICAL TECHNOLOGIES, INC.

Inventor： VNUS MEDICAL TECHNOLOGIES, INC. ,  LAUFER, Michael, D. ,  MILLER, Gary, H. ,  PARKER, Mark, P.

IPC: A61B17/068

CPC classification number: A61B17/0684 ,  A61B17/00234 ,  A61B90/39 ,  A61B2090/3925

Abstract: A delivery device for intraluminally deploying a clip appliance (30) within a body lumen or cavity of a patient, for example a vein. The clip (30) is configured from a wire-like, bendable material, having a "W"-like sinusoidal shape. The clip is constructed with sharpened slanted edges at the tips (31 and 32) which provide preferential bending and straightening when the clip is deployed into a venous valve. The delivery device comprises a catheter (50) and a structure (95) for bending and releasing the clip. The catheter is configured with an elongate flexible tubular member secured to a slotted housing (55) having a distal tapered tip. A handle (140) is secured to the proximal end of the flexible tubular member. A balloon (130) and actuator arm (100) combination forces a clip (30) against an anvil (95) to bend the clip from an open to a closed condition and for releasing the clip from a slot (58) in a side wall of the housing. The housing may be configured to retain and deploy a plurality of clip appliances. During clip deployment, the catheter housing is positioned within a vessel or viscus of a patient, and the slot in the side wall is precisely aligned and stabilized with a second inflatable member. A force is applied to bend and secure the clip to the desired location, and the clip is released from the delivery device through the slot in the housing.

Abstract translation: 用于在患者的体腔或腔内（例如静脉）内部夹持夹具装置（30）的递送装置。 夹子（30）由具有“W”状正弦形状的线状可弯曲材料构成。 夹子在尖端（31和32）处具有锐化的倾斜边缘，当夹子展开到静脉瓣中时，其提供优先弯曲和矫直。 输送装置包括用于弯曲和释放夹子的导管（50）和结构（95）。 导管配置有固定到具有远端锥形尖端的开槽壳体（55）的细长柔性管状构件。 手柄（140）固定到柔性管状构件的近端。 气球（130）和致动器臂（100）组合迫使夹子（30）抵靠砧座（95）将夹子从打开状态弯曲到关闭状态，并且用于将夹子从侧壁中的狭槽（58）释放 的住房。 壳体可以被配置为保持和展开多个夹具装置。 在夹子展开期间，导管壳体定位在患者的容器或粘液内，并且侧壁中的狭缝用第二可充气构件精确对准和稳定。 施加力以将夹子弯曲并固定到期望的位置，并且夹子通过壳体中的槽从输送装置释放。

公开(公告)号：WO1996020655A1

公开(公告)日：1996-07-11

申请号：PCT/US1995014803

申请日：1995-11-13

Applicant: VNUS MEDICAL TECHNOLOGIES, INC.

Inventor： VNUS MEDICAL TECHNOLOGIES, INC. ,  LAUFER, Michael, D. ,  MONTGOMERY, H., DuBose

IPC: A61F02/24

CPC classification number: A61F2/2475 ,  A61B17/122

Abstract: The invention is embodied in an appliance or a prosthesis and a delivery catheter for use in a vein for minimally invasive treatment of chronic venous insufficiency. The system and method of the invention eliminate the need for open surgical valve repair procedures, obviate the need for arm vein transplantation into the leg, and allow patients to return to their former active lifestyles without the limitations currently associated with the treatment of this condition. An incompetent valve to be repaired is identified by injected contrast through the delivery catheter or similar means and the catheter is positioned at that valve, a clip appliance or similar prosthesis is deployed from the catheter and affixed to the valve. Next, the delivery catheter is repositioned and appliances or prostheses are deployed on sequentially lower valves until all desired valves are repaired and functionally competent.

Abstract translation: 本发明体现在用于静脉中用于慢性静脉功能不全的微创治疗的器具或假体和输送导管中。 本发明的系统和方法消除了对开放式手术瓣膜修复程序的需要，从而避免了将臂静脉移植到腿部中的需要，并且允许患者返回到其以前的活跃生活方式，而没有目前与该病症的治疗相关的限制。 通过输送导管或类似装置的注射对比来识别待修复的无能的瓣膜，并且导管定位在该阀处，夹具装置或类似的假体从导管部署并固定到瓣膜上。 接下来，输送导管被重新定位，并且将器具或假体部署在顺序下降的阀上，直到所有期望的阀被修复和功能上胜任。

公开(公告)号：WO1997032532A1

公开(公告)日：1997-09-12

申请号：PCT/US1997003637

申请日：1997-03-04

Applicant: VNUS MEDICAL TECHNOLOGIES, INC.

Inventor： VNUS MEDICAL TECHNOLOGIES, INC. ,  LAUFER, Michael, D. ,  FARLEY, Brian, E. ,  SCHULZ, Grace, Y. ,  ZIKORUS, Arthur, W. ,  PARKER, Mark, P.

IPC: A61B17/39

CPC classification number: A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

Abstract: A catheter (10) delivers at least one electrode (12) within a vein for a minimally invasive procedure using RF energy. The catheter (10) is introduced into a patient and positioned within the section of the vein to be treated. The electrode (12) radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. A bowable member (32) can be controlled to limit the amount of shrinkage of the vein to the diameter defined by the member (32). The electrode (12) remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter (10) and the electrode (12) can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract translation: 导管（10）在静脉内递送至少一个电极（12），以使用RF能量进行微创手术。 将导管（10）引入患者体内并定位在待治疗的静脉的部分内。 电极（12）向静脉辐射高频能量，周围的静脉组织变热并开始收缩。 可以控制可弯曲构件（32）以将静脉的收缩量限制为由构件（32）限定的直径。 电极（12）保持有效，直到静脉充分收缩。 静脉收缩的程度可以通过荧光透视法检测。 在处理静脉的一部分后，导管（10）和电极（12）可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。