公开(公告)号：WO1995008343A1

公开(公告)日：1995-03-30

申请号：PCT/US1994010820

申请日：1994-09-23

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  ATKINSON, John, P. ,  HOURCADE, Dennis ,  KRYCH, Malgorzata

IPC: A61K38/17

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K2319/00

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.

Abstract translation: 描述了具有改变靶C3b和/或C4b的特异性和亲和力的补体激活（RCA）蛋白质的调节剂的类似物。 这些类似物是通过取代影响这些蛋白质的补体抑制活性的氨基酸，取代，重排或添加蛋白质的SCR或SCR区域，缺失氨基酸序列及其组合而获得的。

公开(公告)号：EP0730469B1

公开(公告)日：2004-04-28

申请号：EP94929330.2

申请日：1994-09-23

Applicant: WASHINGTON UNIVERSITY

Inventor： ATKINSON, John P. ,  HOURCADE, Dennis ,  KRYCH, Malgorzata

IPC: A61K38/17 ,  C07K14/435 ,  C07K14/705 ,  C12N15/12 ,  C12P21/00 ,  C07K14/47

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K2319/00

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.

公开(公告)号：EP0730469A1

公开(公告)日：1996-09-11

申请号：EP94929330.0

申请日：1994-09-23

Applicant: WASHINGTON UNIVERSITY

Inventor： ATKINSON, John P. ,  HOURCADE, Dennis ,  KRYCH, Malgorzata

IPC: C12N15 ,  A61K38 ,  A61P9 ,  A61P11 ,  A61P43 ,  C07K5 ,  C07K7 ,  C07K14 ,  C12P21 ,  G01N33

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K2319/00

Abstract: Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs or SCR regions to the proteins, deleting amino acid sequences, and combinations thereof.