公开(公告)号：WO1992019248A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003609

申请日：1992-05-01

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  STAHL, Philip, D.

IPC: A61K31/70

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/001 ,  Y02A50/478

Abstract: Polypeptide backbones containing sugar residues at repetitive intervals are capable of binding the mannose receptor when said sugars are mannosyl, fucosyl, or N-acetyl glucosamine residues. These peptides are of the formula X-(Z(S)AAn1)n2-Y (I) wherein S represents a mannose, fucose, glucose or N-acetylglucosamine residue optionally coupled to a linker moiety; Z is the residue of an amino acid to which S is coupled; each AA is independently the residue of an additional amino acid, n1 is an integer = 1, 2 or 3; n2 is 3-15, and X and Y are noninterfering substituents. They are useful in the treatment of various diseases mediated by macrophage activity and proliferation.

Abstract translation: 当所述糖是甘露糖基，岩藻糖基或N-乙酰氨基葡萄糖残基时，以重复间隔含有糖残基的多肽骨架能够结合甘露糖受体。 这些肽具有式X-（Z（S）AAn1）n2-Y（I），其中S表示任选地与接头部分偶联的甘露糖，岩藻糖，葡萄糖或N-乙酰氨基葡萄糖残基; Z是S连接的氨基酸的残基; 每个AA独立地是另外的氨基酸的残基，n1是整数= 1,2或3; n2为3-15，X和Y为非干扰取代基。 它们可用于治疗由巨噬细胞活性和增殖介导的各种疾病。