公开(公告)号：GB2523873A

公开(公告)日：2015-09-09

申请号：GB201420981

申请日：2014-11-26

Applicant: WATERS TECHNOLOGIES CORP

Inventor： GERHARDT GEOFF ,  FOGWILL MICHAEL ,  MURPHY JAMES ,  MICHIENZI JOSEPH

IPC: H01J49/16 ,  H01J49/10

Abstract: Interfaces suitable for connecting chromatography systems and mass spectrometers comprising, an ion source 112 including a first conduit 114 suitable for receiving eluent from a chromatography device, a heater 116 suitable for heating at least a portion of said first conduit, a second conduit 118 in fluid communication with the first conduit, an inlet 120 suitable for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet 124 suitable for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume. The ion source may be an electrospray ion source, an impactor spray ion source or an APCI ion source. The ion source may comprise a temperature or pressure sensor and feedback loop system for maintaining the temperature or pressure of the eluent.

公开(公告)号：DE102014218057A1

公开(公告)日：2015-03-19

申请号：DE102014218057

申请日：2014-09-10

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL O ,  MICHIENZI JOSEPH D ,  MURPHY JAMES ,  GERHARDT GEOFF

IPC: G01N30/68

Abstract: Die vorliegende Erfindung betrifft einen mikrofluidischen Flammenionisationsdetektor zur Verwendung bei Trennungen im kleinen Maßstab, wie beispielweise bei der mikrofluidischen Gaschromatographie und der mikrofluidischen kohlendioxidbasierten Fluidchromatographie. Bei einigen Anordnungen verwendet der mikrofluidische Gegenstrom-Flammenionisationsdetektor eine nicht parallele Anordnung für die Aufgabe von Verbrennungsgasen in die Brennkammer. Bei anderen Anordnungen ist das Detektorgehäuse so konfiguriert, um mindestens eine der Detektorelektroden in dem Gehäuse unter Verwendung von elektrisch isolierenden Verbindungsstücken zu integrieren.

公开(公告)号：DE102014218057B4

公开(公告)日：2018-04-12

申请号：DE102014218057

申请日：2014-09-10

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL O ,  MICHIENZI JOSEPH D ,  MURPHY JAMES ,  GERHARDT GEOFF

IPC: G01N30/68 ,  B01D15/00

Abstract: Mikrofluidischer Flammenionisationsdetektor, umfassend: eine mikrofluidische Detektorplattform (8), die aus Metall-, Keramik-, kohlenstofffreien Polymersubstraten oder Kombinationen davon besteht, einen in der Detektorplattform (8) ausgebildeten mikrofluidischen Einlasskanal (15) für Sauerstoff, der ein Einlasskanalende (16) hat, einen in der Detektorplattform (8) ausgebildeten mikrofluidischen Einlasskanal (17) für Eluat und Wasserstoff, der ein Einlasskanalende (18) hat, eine in der Detektorplattform (8) ausgebildete Durchgangsöffnung (20), die quer zu den Einlasskanälen (15, 17) angeordnet ist und in die die Einlasskanalenden (16, 18) münden, wobei zum Verschließen der Durchgangsöffnung (20) auf den beiden gegenüberliegenden Seiten der Detektorplattform (8) jeweils ein elektrisch isoliertes Verbindungsstück (26) angebracht ist und dadurch eine Brennkammer ausgebildet wird, eine Polarisationselektrode (12) mit einem ersten Potential, eine Kollektorelektrode (14) mit einem zweiten Potential, das größer ist als das erste Potential, wobei zumindest ein Verbindungsstück (26) als Polarisationselektrode (12) oder als Kollektorelektrode (14) ausgebildet ist.

公开(公告)号：GB2530828A

公开(公告)日：2016-04-06

申请号：GB201506039

申请日：2015-04-09

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL ,  MICHIENZI JOSEPH ,  MURPHY JAMES

IPC: G01N30/68

Abstract: A method of matching a chromatographic column with a flame ionization detector (FID) inner burner, comprising: (i) providing a chromatographic column with an internal diameter; (ii) determining an optimal mobile phase flow rate for the chromatographic column; (iii) calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance; and (iv) providing a FID inner burner having an inner diameter substantially equal to the calculated optimal inner diameter. Preferably the mobile phase comprises carbon dioxide, helium, or nitrogen. Preferably the detector is for carbon dioxide based chromatography, such as supercritical fluid (SCF) chromatography. Also claimed is a chromatography apparatus comprising (i) a chromatography column capable of separating one or more analytes based on a chemical or physical property; and (ii) a flame ionization detector disposed in fluid communication downstream of the column, wherein the flame ionization detector has a fixed outer burner that accommodates a plurality of inner burners that each have a different size that corresponds to a mobile phase flow rate.

公开(公告)号：GB2524853A

公开(公告)日：2015-10-07

申请号：GB201417617

申请日：2014-10-06

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL ,  MICHIENZI JOSEPH ,  MURPHY JAMES

IPC: G01N30/68 ,  B01D15/10 ,  F23N5/00 ,  G01N30/62

Abstract: A method for maintaining flame characteristics in a flame-based detector, the method comprising: providing a chromatographic system 1000 having a mobile phase flow stream in fluid communication with the flame-based detector1060 and upstream of the detector. The mobile phase flow stream entering the flame-based detector has an adjustable mass flow rate. The method also includes determining a mass flow rate of a non-combustion portion of the mobile phase flow stream entering the flame-based detector; and adjusting a mass flow rate of a combustion gas entering the flame-based detector in response to the mass flow rate of the non-combustion portion of the flow stream entering the detector to maintain the flame characteristics. The combustion gas is adjusted with respect to the determined mass flow rate of the non-combustion portion of the flow stream. Further methods for maintaining flame characteristics in a flame-based detector are also disclosed. Advantageously the methods substantially eliminate and/or reduce variability in the flame-based detector response when performing density gradient separations.

公开(公告)号：GB2523873B

公开(公告)日：2016-04-20

申请号：GB201420981

申请日：2014-11-26

Applicant: WATERS TECHNOLOGIES CORP

Inventor： GERHARDT GEOFF ,  FOGWILL MICHAEL ,  MURPHY JAMES ,  MICHIENZI JOSEPH

IPC: H01J49/16 ,  H01J49/10

公开(公告)号：GB2524853B

公开(公告)日：2016-03-30

申请号：GB201417617

申请日：2014-10-06

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL ,  MICHIENZI JOSEPH ,  MURPHY JAMES

IPC: G01N30/68 ,  B01D15/10 ,  F23N5/00 ,  G01N30/62

Abstract: Methods and apparatus for the modulation of flame gas stoichiometry to a flame-based detector for use in chromatographic separations are presented. As the total mass flow rate of mobile phase entering the flame-based detector changes (e.g., as a result of density programming in the separation), the mass flow rate of combustion gases to the detector are altered in proportion to the amount of mobile phase entering the detector. As a result, flame stability and sensitivity of the detector can be maintained by the methods and apparatus of the present disclosure.

公开(公告)号：GB2523212A

公开(公告)日：2015-08-19

申请号：GB201416137

申请日：2014-09-12

Applicant: WATERS TECHNOLOGIES CORP

Inventor： FOGWILL MICHAEL ,  MICHIENZI JOSEPH ,  MURPHY JAMES ,  GERHARDT GEOFF

IPC: G01N30/68 ,  G01N27/62

Abstract: A microfluidic flame ionization detector comprises: (i) a housing 10; (ii) a combustion chamber 20 contained within the housing; (iii) a microfluidic oxygen inlet 16 contained within the housing and in fluid communication with the combustion chamber; (iv) a microfluidic effluent and hydrogen inlet 18 contained within the housing and in fluid communication with the combustion chamber; (v) a polarizer electrode 12, held at a first potential; (vi) a collector electrode 14 held at a second potential, greater than the first. A portion of the housing functions as at least one of the polarizer electrode or collector electrode. Preferably, at least two portions of the housing are electrically isolated base electrodes. The detector may be used in microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. The device may employ a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings (see figure 2).