公开(公告)号：WO2017127516A8

公开(公告)日：2017-08-24

申请号：PCT/US2017014092

申请日：2017-01-19

Applicant: WATERS TECHNOLOGIES CORP

Inventor： TARAFDER ABHIJIT

IPC: G05D7/06 ,  B01D15/18 ,  G01N30/16

CPC classification number: B01D17/12 ,  B01D11/0219 ,  G01N1/4055 ,  G01N30/02 ,  G01N35/1097 ,  G01N2001/4061 ,  G01N2035/0444

Abstract: In a chromatography system, including within the system an extraction vessel which receives a mixture of mobile phase and co-solvent and provides a mixture of mobile phase and co-solvent with sample to a chromatography column to increase sample concentration within the mixture. In addition, adding a reservoir to the chromatography system to form an extraction-pressurization system, wherein the mixture with sample may be collected in the reservoir and may diffuse and equilibrate to an approximately uniform sample concentration before being provided to the chromatography column. Also in addition, providing a plurality of extraction-pressurization systems to allow near-simultaneous extraction of sample and loading of the column, or concurrent extraction and loading by the plurality of extraction-pressurization systems.

Abstract translation: 在色谱系统中，包括系统内的提取容器，其接收流动相和共溶剂的混合物，并将流动相和共溶剂与样品的混合物提供给色谱柱以增加混合物内的样品浓度。 另外，向色谱系统添加储库以形成提取 - 加压系统，其中与样品的混合物可以被收集在储库中并且可以在被提供给色谱柱之前扩散并且平衡成大致均匀的样本浓度。 另外，提供多个抽取 - 加压系统以允许近乎同时地抽取样本并装载柱，或者通过多个抽取 - 加压系统同时抽取和装载。