公开(公告)号：ZA7501650B

公开(公告)日：1976-10-27

申请号：ZA7501650

申请日：1975-03-17

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  DE MIRANDA P ,  ELION G ,  SCHAEFFER H

IPC: C07D239/48 ,  C07D475/06 ,  C07H19/16 ,  C07C ,  A61K

CPC classification number: C07D475/06 ,  C07D239/48 ,  C07H19/16

公开(公告)号：ZA751650B

公开(公告)日：1976-10-27

申请号：ZA751650

申请日：1975-03-17

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  DE MIRANDA P ,  ELION G ,  SCHAEFFER H

IPC: C07D239/48 ,  C07D475/06 ,  C07H19/16 ,  C07C ,  A61K

Abstract: Pharmaceutical preparations containing compounds of the formula where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.