公开(公告)号：EP0984698A2

公开(公告)日：2000-03-15

申请号：EP98902901.2

申请日：1998-02-17

Applicant: WESTAIM TECHNOLOGIES INC.

Inventor： BURRELL, Robert, Edward ,  PRECHT, Roderick, John

IPC: A01N59/00

CPC classification number: A61L31/16 ,  A01N59/16 ,  A61F13/00008 ,  A61F13/00029 ,  A61F13/00055 ,  A61F13/00059 ,  A61F13/00063 ,  A61F13/00991 ,  A61F2013/00157 ,  A61F2013/00234 ,  A61F2013/00519 ,  A61F2013/00587 ,  A61F2013/0091 ,  A61F2013/00936 ,  A61F2013/00965 ,  A61L15/18 ,  A61L15/46 ,  A61L17/005 ,  A61L29/16 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2300/608 ,  Y10T428/24793 ,  Y10T428/24826 ,  Y10T428/249921 ,  Y10T428/256 ,  Y10T428/2848 ,  A01N2300/00

Abstract: Multilayer anti-microbial materials formed to produce an interference colour, and thus an indictor of anti-microbial effect, are provided. The materials include a partly reflective base layer and a partly reflective, partly transmissive top layer balanced to produce an interference colour. The top layer is formed from an anti-microbial metal with atomic disorder. Dissolution or a change in composition of the top layer on contacting an alcohol or electrolyte causes a change in optical path length so as to produce a change in the interference colour of the material. Multilayer, laminated wound dressings are also provided. The dressing includes a first and second layer, and preferably a third layer. The first and third layers are formed of perforated, non-adherent materials and most preferably carry an anti-microbial coating as above. The second layer is sandwiched between the first and third layers and is formed of an absorbent material. At least one of the layers is formed from a plastic material. The layers are laminated together by ultrasonic welds spaced intermittently on the dressing to allow the dressing to be cut to size with delaminating.

公开(公告)号：EP0729302B1

公开(公告)日：2000-03-08

申请号：EP94931472.8

申请日：1994-11-01

Applicant: WESTAIM TECHNOLOGIES INC.

Inventor： BURRELL, Robert, Edward ,  APTE, Prasad, Shrikrishna ,  GILL, Kashmir, Singh ,  PRECHT, Roderick, John ,  MORRIS, Larry, Roy ,  MCINTOSH, Catherine, Laurie ,  SANT, Sudhindra, Bharat

IPC: A01N59/16 ,  A61L2/16 ,  C23C14/14

CPC classification number: C23C14/588 ,  A01N59/16 ,  A01N59/26 ,  A61B2018/00119 ,  A61L17/145 ,  A61L29/106 ,  C23C14/0036 ,  C23C14/025 ,  C23C14/06 ,  C23C14/0688 ,  C23C14/086 ,  C23C14/14 ,  C23C14/16 ,  A01N47/30 ,  A01N43/80 ,  A01N43/78 ,  A01N41/08 ,  A01N2300/00

公开(公告)号：EP0729302A1

公开(公告)日：1996-09-04

申请号：EP94931472.0

申请日：1994-11-01

Applicant: WESTAIM TECHNOLOGIES INC.

Inventor： BURRELL, Robert, Edward ,  APT , Prasad, Shrikrishna ,  GILL, Kashmir, Singh ,  PRECHT, Roderick, John ,  MORRIS, Larry, Roy ,  MCINTOSH, Catherine, Laurie ,  SANT, Sudhindra, Bharat

IPC: A61L2 ,  A01N37 ,  A01N47 ,  A01N59 ,  A61L17 ,  A61L29 ,  C23C14

CPC classification number: C23C14/588 ,  A01N59/16 ,  A01N59/26 ,  A61B2018/00119 ,  A61L17/145 ,  A61L29/106 ,  C23C14/0036 ,  C23C14/025 ,  C23C14/06 ,  C23C14/0688 ,  C23C14/086 ,  C23C14/14 ,  C23C14/16 ,  A01N47/30 ,  A01N43/80 ,  A01N43/78 ,  A01N41/08 ,  A01N2300/00

Abstract: Anti-microbial coatings and powders and method of forming same on medical devices are provides. The coatings are preferably formed by depositing an anti-microbial biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by vapour deposition or altered by mechanical working to produce atomic disorder are also provided. The anti-microbial effect of the coatings or powders may be further activated or enhanced by irradiating with a low linear energy transfer form of radiation such as gamma radiation. Novel anti-microbial silver materials are defined, characterized by having a positive rest potential, a Trec/Tm less than 0.33, and a grain size less than 200 nm. Anti-microbial fine grain or nanocrystalline materials are provided, together with methods of preparation, wherein the anti-microbial metal if deposited in a matrix with atoms or molecules of a different material such as other biocompatible metals (ex. Ta), trapped or absorbed oxygen, or compounds of anti-microbial metals or biocompatible metals (ex. Ag0 or TaO). The invention also extends to a method of producing an anti-microbial effect with silver materials that form complex silver ions other than Ag?+, Ag2+ and Ag3+¿.

Abstract translation: 提供了抗微生物涂层和粉末及其在医疗器械上的形成方法。 涂层优选通过气相沉积技术沉积抗微生物生物相容性金属而形成，以在涂层中产生原子无序，从而实现足以产生抗微生物效应的金属离子的持续释放。 实现原子无序的优选沉积条件包括低于正常基底温度，以及高于正常工作气体压力和低于正常涂覆焊剂入射角的一个或多个。 还提供了通过气相沉积形成或通过机械加工而产生以产生原子无序的抗微生物粉末。 涂层或粉末的抗微生物效果可以通过用低线性能量转移形式的辐射例如γ辐射照射来进一步激活或增强。 定义了新的抗微生物银材料，其特征在于具有正静息电位，小于0.33的Trec / Tm和小于200nm的晶粒尺寸。 提供了抗微生物细颗粒或纳米晶体材料以及制备方法，其中抗微生物金属如果沉积在具有不同材料的原子或分子如其它生物相容性金属（例如Ta）中的俘获或吸收的基质中 氧或抗微生物金属或生物相容性金属（例如Ag0或TaO）的化合物。 本发明还涉及用银材料产生抗微生物作用的方法，所述银材料形成除Ag +，Ag2 +和Ag3 +以外的复合银离子。