公开(公告)号：WO2022232389A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026727

申请日：2022-04-28

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： HEIGHTON, Carolyn ,  GAUDETTE, Logan ,  KALESHIAN, Gregory ,  HOLM, Camden ,  BONARRIGO, Paul ,  PINS, George ,  MAGIT, David ,  PHANEUF, Matthew ,  LONG, Nathaniel ,  KASSAB, Rayan

IPC: A61F2/08 ,  A61L27/56 ,  A61L27/54 ,  A61L27/24 ,  A61L27/36

Abstract: A ligament repair device and method is particularly suited to the demands of UCL repair using a scaffold device for surgical implantation across a torn ligament section. The implantable device includes an encapsulation of a therapeutic element for increasing cell proliferation and growth eluted through a controlled release storage element adapted to release the therapeutic agent over time as the cell growth progresses and the scaffold structure degrades or is absorbed in favor of the new cell growth for ligament repair. Reduced recovery time is afforded by the need for only an relatively small incision for implantation. The introduction of a physiologically relevant drug delivery scaffold encourages more rapid cell growth over passive, physical repairs to the connective tissue.

公开(公告)号：WO2011116250A2

公开(公告)日：2011-09-22

申请号：PCT/US2011/028909

申请日：2011-03-17

Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  PINS, George ,  CAREY, Shawn

Inventor： PINS, George ,  CAREY, Shawn

IPC: D06M10/00 ,  A61L27/14 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/54 ,  A61B19/02

CPC classification number: D06M10/00 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12099 ,  A61B17/12181 ,  A61B2017/00884 ,  A61L17/00 ,  A61L27/3804 ,  A61L27/52 ,  A61L27/54 ,  A61L2400/18 ,  D01D5/247 ,  D01F4/00 ,  Y10T428/2978

Abstract: In one aspect, the invention features a textured microthread that includes or is fashioned from a naturally occurring polymer and that has a surface comprising micron-scale ridges with intervening grooves.

Abstract translation: 在一个方面，本发明的特征在于纹理微丝线，其包括或由天然存在的聚合物形成，并且具有包括具有中间凹槽的微米级脊的表面。