公开(公告)号：WO2017160862A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022336

申请日：2017-03-14

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  ARKANSAS STATE UNIVERSITY - JONESBORO ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： MURPHY, William ,  FONTANA, Gianluca ,  GERSHIAK, Josh ,  GAUDETTE, Glenn ,  WEATHERS, Pam ,  DOMINKO, Tanja ,  ROLLE, Marsha ,  HERNANDEZ, Sarah ,  CRAMER, Carol ,  MEDINA-BOLIVAR, Fabricio

IPC: A61L27/40 ,  C08G63/91 ,  G01N33/566 ,  C40B30/04 ,  A61K47/48

CPC classification number: A61L27/3637 ,  A61L27/12 ,  A61L27/227 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/414 ,  C12N5/0068 ,  C12N5/04 ,  C12N2533/90 ,  C12N2535/00

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Abstract translation: 本文公开了脱细胞化的植物组织和这些植物组织作为支架的用途。 特别地，去细胞化的植物组织被功能化以允许人细胞粘附，从而允许它们用作人细胞的支架。 这些支架可以用于许多应用/市场，包括作为组织工程，再生医学和基础细胞生物学的研究工具。

公开(公告)号：WO2014004719A2

公开(公告)日：2014-01-03

申请号：PCT/US2013/047975

申请日：2013-06-26

Applicant: ROLLE, Marsha ,  PRIFTI, Fioleda ,  MALCUIT, Chris ,  CAMESANO, Terri ,  DOMINKO, Tanja ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： ROLLE, Marsha ,  PRIFTI, Fioleda ,  MALCUIT, Chris ,  CAMESANO, Terri ,  DOMINKO, Tanja

IPC: C07K14/78

CPC classification number: A61L27/54 ,  A61L2300/404 ,  C07K14/4723 ,  C07K14/78 ,  C07K2319/00 ,  C12N15/62

Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto, The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

Abstract translation: 本发明提供了具有与其连接的重组嵌合肽的细胞外基质聚合物的支架。本发明还提供抗微生物肽和细胞外基质结合结构域的重组嵌合肽。 本发明还提供了使用支架和/或重组嵌合肽治疗慢性伤口的方法。

公开(公告)号：WO2017106512A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/066950

申请日：2016-12-15

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： PETERSON, Amy ,  ROLLE, Marsha ,  DING, Ivan

IPC: A61K38/43 ,  A61K38/02 ,  A61P43/00

CPC classification number: C12N13/00 ,  C12M21/08 ,  C12M23/20 ,  C12M25/14 ,  C12N5/0068

Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.

Abstract translation: 公开了装置以及使用或制造该装置以在体外工程化细胞的方法。 在一些方面，细胞培养装置包含至少一个配置用于在培养基中培养细胞的玻璃或聚合物表面; 带电分子静电结合到表面; 和与带电分子静电结合的聚电解质多层（PEM），所述PEM包含一个或多个带相反电荷的聚电解质的双层，并且所述PEM具有足够的厚度以允许带电分子以受控释放释放到培养基中 方式。

公开(公告)号：WO2018165517A1

公开(公告)日：2018-09-13

申请号：PCT/US2018/021691

申请日：2018-03-09

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： GARVEY, Lucy ,  HASSAN, Lubna ,  NICHOLS, Kyla ,  PAQUIN, Allison ,  DANIELLO, Robert J. ,  ROLLE, Marsha

IPC: A61B5/08 ,  A61B5/091 ,  A61B5/087 ,  A01K29/00 ,  G01F1/68

CPC classification number: A61B5/0878 ,  A61B5/0809 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1135 ,  A61B2503/40 ,  A61B2562/0271 ,  A61B2562/029

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.

公开(公告)号：WO2008116189A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/057928

申请日：2008-03-21

Applicant: WORCESTER POLYTECHNIC INSTITUTE (WPI) ,  GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

Inventor： GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

IPC: A61B17/10

CPC classification number: A61L31/046 ,  A61B17/0469 ,  A61B17/06 ,  A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00893 ,  A61L27/225 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3873 ,  A61L31/16 ,  A61L2430/20 ,  C12N5/0068 ,  C12N11/02 ,  C12N2533/56

Abstract: Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium).

Abstract translation: 提供包括微丝的组合。 组合物可以沿其长度的至少一部分完全或部分地包封在套管中，并且可以包括生物细胞和任选的治疗剂。 还提供了使用组合物来修复或改善包括心血管组织（例如心肌）的损伤或缺陷组织的方法。