公开(公告)号：WO2016094802A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/065256

申请日：2015-12-11

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： HERNANDEZ, Sarah ,  DOMINKO, Tanja

IPC: C12Q1/68 ,  C12N9/10 ,  C12N15/52

CPC classification number: C12Q1/6886 ,  A61B18/02 ,  C12N9/1007 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/91011

Abstract: The invention features compositions and methods for a pre-cancer prognostic screen.

Abstract translation: 本发明的特征在于用于癌前预后筛选的组合物和方法。

公开(公告)号：WO2017160862A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022336

申请日：2017-03-14

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  ARKANSAS STATE UNIVERSITY - JONESBORO ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： MURPHY, William ,  FONTANA, Gianluca ,  GERSHIAK, Josh ,  GAUDETTE, Glenn ,  WEATHERS, Pam ,  DOMINKO, Tanja ,  ROLLE, Marsha ,  HERNANDEZ, Sarah ,  CRAMER, Carol ,  MEDINA-BOLIVAR, Fabricio

IPC: A61L27/40 ,  C08G63/91 ,  G01N33/566 ,  C40B30/04 ,  A61K47/48

CPC classification number: A61L27/3637 ,  A61L27/12 ,  A61L27/227 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/414 ,  C12N5/0068 ,  C12N5/04 ,  C12N2533/90 ,  C12N2535/00

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Abstract translation: 本文公开了脱细胞化的植物组织和这些植物组织作为支架的用途。 特别地，去细胞化的植物组织被功能化以允许人细胞粘附，从而允许它们用作人细胞的支架。 这些支架可以用于许多应用/市场，包括作为组织工程，再生医学和基础细胞生物学的研究工具。

公开(公告)号：WO2014004719A2

公开(公告)日：2014-01-03

申请号：PCT/US2013/047975

申请日：2013-06-26

Applicant: ROLLE, Marsha ,  PRIFTI, Fioleda ,  MALCUIT, Chris ,  CAMESANO, Terri ,  DOMINKO, Tanja ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： ROLLE, Marsha ,  PRIFTI, Fioleda ,  MALCUIT, Chris ,  CAMESANO, Terri ,  DOMINKO, Tanja

IPC: C07K14/78

CPC classification number: A61L27/54 ,  A61L2300/404 ,  C07K14/4723 ,  C07K14/78 ,  C07K2319/00 ,  C12N15/62

Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto, The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

Abstract translation: 本发明提供了具有与其连接的重组嵌合肽的细胞外基质聚合物的支架。本发明还提供抗微生物肽和细胞外基质结合结构域的重组嵌合肽。 本发明还提供了使用支架和/或重组嵌合肽治疗慢性伤口的方法。

公开(公告)号：EP3853346A1

公开(公告)日：2021-07-28

申请号：EP19861733.4

申请日：2019-09-20

Applicant: Worcester Polytechnic Institute

Inventor： GAUDETTE, Glenn ,  DOMINKO, Tanja ,  GERSHLAK, Joshua ,  PERLMAN, Brent

IPC: C12N5/07 ,  C12N5/0789 ,  C12N5/0797

公开(公告)号：WO2020061500A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/052231

申请日：2019-09-20

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： GAUDETTE, Glenn ,  DOMINKO, Tanja ,  GERSHLAK, Joshua ,  PERLMAN, Brent

IPC: C12N5/07 ,  C12N5/0789 ,  C12N5/0797

Abstract: Methods and systems for increasing oxygen for use by mammalian cells are provided. In some embodiments, a method for increasing oxygen concentration for mammalian cells coculturing chloroplasts in at least one well plate with mammalian cells in a media and increasing oxygen production by exposing the chloroplasts to light.

公开(公告)号：WO2011112976A3

公开(公告)日：2011-09-15

申请号：PCT/US2011/028169

申请日：2011-03-11

Applicant: MAKRIDAKIS, Jennifer ,  PINS, George D. ,  PAGE, Raymond Lynn ,  DOMINKO, Tanja ,  MALCUIT, Christopher ,  Worcester Polytechnic Institute

Inventor： MAKRIDAKIS, Jennifer ,  PINS, George D. ,  PAGE, Raymond Lynn ,  DOMINKO, Tanja ,  MALCUIT, Christopher

IPC: A61F2/08 ,  A61L27/14 ,  A61L27/24 ,  A61L27/54 ,  A61L27/38

Abstract: An engineered muscle construct in the form of a braided collagen microthread scaffold is provided. The microthread scaffold can be used with or without cells as engineered skeletal muscle. The microthread scaffold can also be used to promote cell attachment and growth to deliver cells to a large muscle defect to stimulate muscle regeneration. Methods for making a muscle construct, seeding cells onto microthread scaffolds and treating muscle defects are also provided.

公开(公告)号：WO2009111087A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/001517

申请日：2009-03-09

Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  PAGE, Raymond, L. ,  DOMINKO, Tanja

Inventor： PAGE, Raymond, L. ,  DOMINKO, Tanja

IPC: C12N5/08

CPC classification number: C12N5/0662 ,  C12N2500/02 ,  C12N2501/115 ,  C12N2506/1307

Abstract: De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de- differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies.

Abstract translation: 本文描述了去分化方案用于从成人结缔组织，特别是成人人成纤维细胞产生祖细胞。 本文描述的去分化方案包括用一定量的FGF2培养分化的细胞以使细胞去分化。 然后可以将这些去分化的细胞培养并用于实验，扩增和临床应用。 临床应用包括使用细胞进行组织和基于细胞的疗法。