公开(公告)号：WO2020061500A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/052231

申请日：2019-09-20

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： GAUDETTE, Glenn ,  DOMINKO, Tanja ,  GERSHLAK, Joshua ,  PERLMAN, Brent

IPC: C12N5/07 ,  C12N5/0789 ,  C12N5/0797

Abstract: Methods and systems for increasing oxygen for use by mammalian cells are provided. In some embodiments, a method for increasing oxygen concentration for mammalian cells coculturing chloroplasts in at least one well plate with mammalian cells in a media and increasing oxygen production by exposing the chloroplasts to light.

公开(公告)号：WO2017160862A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022336

申请日：2017-03-14

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  ARKANSAS STATE UNIVERSITY - JONESBORO ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： MURPHY, William ,  FONTANA, Gianluca ,  GERSHIAK, Josh ,  GAUDETTE, Glenn ,  WEATHERS, Pam ,  DOMINKO, Tanja ,  ROLLE, Marsha ,  HERNANDEZ, Sarah ,  CRAMER, Carol ,  MEDINA-BOLIVAR, Fabricio

IPC: A61L27/40 ,  C08G63/91 ,  G01N33/566 ,  C40B30/04 ,  A61K47/48

CPC classification number: A61L27/3637 ,  A61L27/12 ,  A61L27/227 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/414 ,  C12N5/0068 ,  C12N5/04 ,  C12N2533/90 ,  C12N2535/00

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Abstract translation: 本文公开了脱细胞化的植物组织和这些植物组织作为支架的用途。 特别地，去细胞化的植物组织被功能化以允许人细胞粘附，从而允许它们用作人细胞的支架。 这些支架可以用于许多应用/市场，包括作为组织工程，再生医学和基础细胞生物学的研究工具。

公开(公告)号：EP3853346A1

公开(公告)日：2021-07-28

申请号：EP19861733.4

申请日：2019-09-20

Applicant: Worcester Polytechnic Institute

Inventor： GAUDETTE, Glenn ,  DOMINKO, Tanja ,  GERSHLAK, Joshua ,  PERLMAN, Brent

IPC: C12N5/07 ,  C12N5/0789 ,  C12N5/0797

公开(公告)号：WO2021231372A1

公开(公告)日：2021-11-18

申请号：PCT/US2021/031701

申请日：2021-05-11

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： REBELLO, Alex S. ,  JONES, Jordan ,  GAUDETTE, Glenn

IPC: A23L13/00 ,  C12N5/02 ,  C12N5/04 ,  C12N5/077 ,  C12M3/04 ,  A23L19/03 ,  A23L33/105 ,  A23V2002/00 ,  C12N2513/00 ,  C12N2533/90 ,  C12N5/0659

Abstract: An in vitro meat having non-decellularized leaf scaffold and a method for producing an in vitro meat using non-decellularized leaf scaffold are described herein. The method includes preparing a non-decellularized plant leaf and incubating the leaf in a cell culture media to obtain a non-decellularized leaf scaffold; seeding the leaf scaffold with a population of muscle cells to obtain a leaf scaffold adhered population of muscle cells; and growing the leaf scaffold adhered population of muscle cells in cell culture media thereby obtaining the in vitro meat.

公开(公告)号：WO2020041612A1

公开(公告)日：2020-02-27

申请号：PCT/US2019/047742

申请日：2019-08-22

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： COBURN, Jeannine ,  GAUDETTE, Glenn ,  PHAN, Nhi

IPC: A61K47/48 ,  A61L27/12 ,  A61L27/22 ,  A61L27/36

Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.

公开(公告)号：WO2008116189A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/057928

申请日：2008-03-21

Applicant: WORCESTER POLYTECHNIC INSTITUTE (WPI) ,  GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

Inventor： GAUDETTE, Glenn ,  PINS, George D. ,  ROLLE, Marsha ,  GUYETTE, Jacques P. ,  CORNWALL, Kevin G.

IPC: A61B17/10

CPC classification number: A61L31/046 ,  A61B17/0469 ,  A61B17/06 ,  A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00893 ,  A61L27/225 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3873 ,  A61L31/16 ,  A61L2430/20 ,  C12N5/0068 ,  C12N11/02 ,  C12N2533/56

Abstract: Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium).

Abstract translation: 提供包括微丝的组合。 组合物可以沿其长度的至少一部分完全或部分地包封在套管中，并且可以包括生物细胞和任选的治疗剂。 还提供了使用组合物来修复或改善包括心血管组织（例如心肌）的损伤或缺陷组织的方法。