公开(公告)号：US20110201942A1

公开(公告)日：2011-08-18

申请号：US13125677

申请日：2009-10-21

Applicant: Marius Iosif Boamfa ,  Wouter Harry Jacinth Rensen

Inventor： Marius Iosif Boamfa ,  Wouter Harry Jacinth Rensen

IPC: A61B6/00

CPC classification number: A61B5/0059 ,  A61B5/4528 ,  A61B5/6825

Abstract: A device for optically examining the interior of a body part by transillumination is provided. The device comprises: an illumination unit (2) adapted for emitting polarized light (8) towards a body part (5) to be examined; and a detector unit (6) adapted for detecting light in transmission. A polarizer (10) is arranged in front of the detector unit (6).

Abstract translation: 提供了通过透照光学检查身体部分的内部的装置。 该装置包括：照明单元（2），适于向待检查的身体部分（5）发射偏振光（8）; 以及适于检测透射光的检测器单元（6）。 偏振器（10）布置在检测器单元（6）的前面。

公开(公告)号：US20090153852A1

公开(公告)日：2009-06-18

申请号：US11568198

申请日：2005-04-12

Applicant: Wouter Harry Jacinth Rensen

Inventor： Wouter Harry Jacinth Rensen

IPC: G01J3/00 ,  G02B6/26 ,  G02B6/02

CPC classification number: G01J3/02

Abstract: The present invention provides an optical fiber for connecting a probe head and a base station of a spectroscopic analysis system for analyzing the molecular composition of a volume of interest. The optical fiber comprises a core for transmission of excitation radiation from the base station to the probe head and a first cladding for transmission of multi-mode return radiation from the probe head to a spectroscopic analysis unit of the base station. Preferably, the first cladding is surrounded by a second cladding and therefore provides a multi-mode wave guide by itself. Appropriately designing the dimensions of the core, the first cladding and the second cladding provides an optimal collection and coupling efficiency of the optical fiber. Coating of the distal end facet of the optical fiber with multi-layer optical filters allows an effective separation of elastically and inelastically scattered radiation which is of advantage for the spectroscopic analysis.

Abstract translation: 本发明提供了用于连接用于分析感兴趣体积的分子组成的光谱分析系统的探针头和基站的光纤。 光纤包括用于从基站传输到探头的激发辐射的核心和用于将多模返回辐射从探头传输到基站的光谱分析单元的第一包层。 优选地，第一包层被第二包层包围，因此本身提供多模式波导。 适当地设计芯的尺寸，第一包层和第二包层提供了光纤的最佳收集和耦合效率。 使用多层光学滤光器对光纤的远端面进行涂覆，可有效地分离弹性和非弹性散射的辐射，这对于光谱分析是有利的。

公开(公告)号：US07405825B2

公开(公告)日：2008-07-29

申请号：US10539540

申请日：2003-12-19

Applicant: Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

Inventor： Frank Jeroen Pieter Schuurmans ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker ,  Wouter Harry Jacinth Rensen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Robert Frans Maria Hendriks ,  Thomas Steffen

IPC: G01J3/32 ,  G01J3/457 ,  G02B26/02

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

Abstract: The optical analysis system (20) for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element (10) for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (9, 9P, 9N) for detecting the weighed optical signal. The optical analysis system (20) may further comprise a dispersive element (2) for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system (40) comprises the optical analysis system (20) according to the invention.

Abstract translation: 用于确定光信号的主分量的幅度的光学分析系统（20）包括用于反射光信号并由此通过光谱称重功能称重光信号的多元光学元件（10） 9 P，9 N），用于检测加权的光信号。 光学分析系统（20）还可以包括用于光谱分散光学信号的色散元件（2），所述多元光学元件被布置成接收分散的光信号。 血液分析系统（40）包括根据本发明的光学分析系统（20）。

公开(公告)号：US10791932B2

公开(公告)日：2020-10-06

申请号：US12992609

申请日：2009-05-20

Applicant: Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

Inventor： Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Rik Harbers

IPC: A61B5/00 ,  A61B5/02

Abstract: An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

公开(公告)号：US08406835B2

公开(公告)日：2013-03-26

申请号：US11568363

申请日：2005-02-14

Applicant: Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

Inventor： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC: A61B5/1455 ,  A61B5/00 ,  G02B6/44

CPC classification number: A61B5/0059 ,  A61B5/489 ,  A61B2562/0242

Abstract: A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.

Abstract translation: 描述了用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。 分光系统包括：探头，其具有用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的目标; 具有光谱分析单元和电源的基站; 以及连接探头和基站的电缆，用于将返回辐射从探头传输到基站，并为探头提供来自基站的电源的电力。

公开(公告)号：US07924140B2

公开(公告)日：2011-04-12

申请号：US11577375

申请日：2005-10-20

Applicant: Robert Frans Maria Hendriks ,  Wouter Harry Jacinth Rensen ,  Antonius Hermanus Maria Akkermans

Inventor： Robert Frans Maria Hendriks ,  Wouter Harry Jacinth Rensen ,  Antonius Hermanus Maria Akkermans

IPC: G05B19/00

CPC classification number: G06K9/0012 ,  G06K9/00013 ,  G06K9/00899 ,  G06K2009/00932

Abstract: The invention relates to an identification method carried out as follows. A surface structure and an inner structure of a body member are measured (ST1-ST4, ST7) so as to obtain a surface-structure measurement result (FPM) and an inner-structure measurement result (BVPM), respectively. The surface-structure measurement result (FPM) is compared (ST5) with a surface-structure reference result (FPR) that distinguishes an individual from other individuals. The inner-structure measurement result (BVPM) is compared (ST8) with an inner-structure reference result (BVPR) that is associated with the same individual and that distinguishes the individual from other individuals. The body member may be, for example, a finger. In that case, the surface structure comprises a fingerprint and the inner structure comprises a blood-vessel pattern.

Abstract translation: 本发明涉及如下进行的识别方法。 测量体部件的表面结构和内部结构（ST1-ST4，ST7），以获得表面结构测量结果（FPM）和内部结构测量结果（BVPM）。 比较表面结构测量结果（FPM）（ST5）与区分个体与其他个体的表面结构参考结果（FPR）。 比较内部结构测量结果（BVPM）（ST8）与与同一个人相关联的内部结构参考结果（BVPR），并将个体与其他个体区分开。 身体构件可以是例如手指。 在这种情况下，表面结构包括指纹，内部结构包括血管图案。

公开(公告)号：US07817268B2

公开(公告)日：2010-10-19

申请号：US11574161

申请日：2005-08-24

Applicant: Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek ,  Gérald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen

Inventor： Bernardus Leonardus Gerardus Bakker ,  Michael Cornelis Van Beek ,  Gérald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen

IPC: G01J3/30

CPC classification number: G01J3/02 ,  G01J1/4228 ,  G01J3/0229 ,  G01J3/0289

Abstract: The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.

Abstract translation: 本发明提供一种光谱系统以及自动调谐光谱系统和相应的计算机程序产品的方法。 通过检测光谱分析单元的孔径的横向平面中的返回辐射的位置，可以产生允许驱动光学部件的伺服驱动的平移或倾斜级的控制信号。 以这种方式，可以有效地检测光谱系统的横向偏移。 通常，多个不同的检测方案是可实现的，允许分光系统的自主调谐并且用于自动消除光谱系统的未对准。

公开(公告)号：US07663748B2

公开(公告)日：2010-02-16

申请号：US11570132

申请日：2005-06-07

Applicant: Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

Inventor： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

IPC: G01J3/30

CPC classification number: G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

Abstract: An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.

Abstract translation: 用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。 该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。 控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如， 毛细血管的中心。

公开(公告)号：US20130310697A1

公开(公告)日：2013-11-21

申请号：US13989800

申请日：2011-11-25

Applicant: Wouter Harry Jacinth Rensen ,  Pieter Klaas De Bokx

Inventor： Wouter Harry Jacinth Rensen ,  Pieter Klaas De Bokx

IPC: A61B5/00

CPC classification number: A61B5/0082 ,  A61B5/0075 ,  A61B5/022 ,  A61B5/0261 ,  A61B5/4528 ,  A61B5/4842 ,  A61B5/6825 ,  A61B5/6829

Abstract: A system and method to determine a disease activity as a single value by way of optical measurements in order to facilitate an analysis of a current disease status and a future course of disease, thus assisting a doctor's diagnosis or decision on a therapy. A blood perfusion is varied in an area of interest, the area of interest is irradiated with light of at least two wavelengths, an intensity of light reflected and/or transmitted by the area of interest is detected, features are derived from detected intensity curves of at least two predetermined wavelengths under at least two different perfusion conditions, and the disease activity is determined using these features.

Abstract translation: 通过光学测量法将疾病活动确定为单一值的系统和方法，以便于分析当前疾病状况和未来疾病进程，从而帮助医生诊断或决定治疗。 在感兴趣的区域中改变血液灌注，用至少两个波长的光照射感兴趣的区域，检测由感兴趣区域反射和/或透射的光的强度，特征是从检测到的强度曲线 在至少两个不同灌注条件下至少两个预定波长，并且使用这些特征确定疾病活动。

公开(公告)号：US20120004547A1

公开(公告)日：2012-01-05

申请号：US13142299

申请日：2010-01-08

Applicant: Erik Harks ,  Szabolcs Deladi ,  Jan Frederik Suijver ,  Ladislav Jankovic ,  Yan Shi ,  Wouter Harry Jacinth Rensen ,  Maya Barley ,  Nijs Cornelis Van Der Vaart

Inventor： Erik Harks ,  Szabolcs Deladi ,  Jan Frederik Suijver ,  Ladislav Jankovic ,  Yan Shi ,  Wouter Harry Jacinth Rensen ,  Maya Barley ,  Nijs Cornelis Van Der Vaart

IPC: A61B8/00 ,  A61B18/12 ,  A61B8/12

CPC classification number: A61B8/0858 ,  A61B8/12 ,  A61B8/445 ,  A61B8/486 ,  A61B18/02 ,  A61B18/1442 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/20 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2018/00738 ,  A61B2090/376 ,  A61B2090/3784 ,  A61B2218/002

Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

Abstract translation: 本发明涉及一种用于监测消融程序的监测装置（101）。 监视装置（101）包括：超声信号提供单元，用于提供取决于被消融的对象（4）的接收到的回波序列的超声信号。 监测装置（101）还包括用于根据所提供的超声信号确定消融深度的消融深度确定单元（103）。 消融深度可以直接从超声信号确定，并且是执行消融过程的重要参数。 例如，它可以用于确定对象（4）内的消融进展并确定消融何时达到期望的进程。