公开(公告)号：EP0512965A1

公开(公告)日：1992-11-11

申请号：EP92850098.2

申请日：1992-05-05

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Jaggi, Bruno ,  Profio, Amedeus Edward ,  Macaulay, Calum ,  Lam, Stephen ,  Hung, Jaclyn

IPC: A61B5/00

CPC classification number: A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6463

Abstract: Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

Abstract translation: 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光引导件用于用至少包括激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织显着不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

公开(公告)号：EP0920831A1

公开(公告)日：1999-06-09

申请号：EP99103430.7

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Macaulay, Calum ,  Lam, Stephen ,  Jaggi, Bruno

IPC: A61B1/05 ,  A61B5/00

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

Abstract translation: 用于成像组织的疾病的装置和方法被呈现。 该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。 光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。 的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。 汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。 监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。 该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。 一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。

公开(公告)号：EP0512965B1

公开(公告)日：1996-07-24

申请号：EP92850098.2

申请日：1992-05-05

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Jaggi, Bruno ,  Profio, Amedeus Edward ,  Macaulay, Calum ,  Lam, Stephen ,  Hung, Jaclyn

IPC: A61B5/00

CPC classification number: A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6463

公开(公告)号：EP0920831B1

公开(公告)日：2005-08-17

申请号：EP99103430.7

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Macaulay, Calum ,  Lam, Stephen ,  Jaggi, Bruno

IPC: A61B1/05 ,  A61B5/00

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

公开(公告)号：EP1472972A1

公开(公告)日：2004-11-03

申请号：EP04018813.8

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Lam, Stephen ,  Macaulay, Calum ,  Jaggi, Bruno

IPC: A61B5/00 ,  A61B1/05

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

Abstract translation: 用于成像组织的疾病的装置和方法被呈现。 该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。 光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。 的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。 汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。 监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。 该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。 一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。