公开(公告)号：US20040196463A1

公开(公告)日：2004-10-07

申请号：US10830680

申请日：2004-04-22

Applicant: Xillix Technologies Corporation

Inventor： Richard W. Cline ,  Pierre Leduc

IPC: G01N021/64

CPC classification number: A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0088

Abstract: A lightweight hand-held skin abnormality detection system includes a source of excitation light that causes tissue under examination to produce fluorescence light. The fluorescence light produced along with the beam of reference light is provided to a beam splitter which divides the fluorescence light and the reference light into separate optical channels. Each optical channel produces an image of the tissue under examination. A passive optical combiner superimposes the image produced by each optical channel for viewing by a user.

Abstract translation: 一种轻质的手持式皮肤异常检测系统，包括使检查中的组织产生荧光的激发光源。 与参考光束一起产生的荧光被提供给分束器，其将荧光和参考光分成单独的光通道。 每个光学通道产生被检查的组织的图像。 无源光学组合器叠加由每个光通道产生的图像以供用户观看。

公开(公告)号：WO1995026673A2

公开(公告)日：1995-10-12

申请号：PCT/CA1995000171

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： XILLIX TECHNOLOGIES CORPORATION ,  PALCIC, Branko ,  MACAULAY, Calum ,  LAM, Stephen ,  JAGGI, Bruno

IPC: A61B00/00

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

Abstract translation: 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。

公开(公告)号：US20030135092A1

公开(公告)日：2003-07-17

申请号：US10050601

申请日：2002-01-15

Applicant: Xillix Technologies Corporation

Inventor： Richard W. Cline ,  John J.P. Fengler

IPC: A61B001/06

CPC classification number: A61B1/0646 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B5/0071 ,  A61B5/0084

Abstract: A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for white light and fluorescence imaging, which may be located in the insertion portion of the endoscope, or attached to the portion of the endoscope outside the body. The camera can be utilized for both white light imaging and fluorescence imaging, and in its most compact form, contains no moving parts.

Abstract translation: 荧光内窥镜视频系统包括产生用于白光和荧光成像模式的光的多模光源。 来自光源的光通过内窥镜透射到观察的组织。 该系统还包括用于白光和荧光成像的小型相机，其可以位于内窥镜的插入部分中，或者附接到身体外部的内窥镜的部分。 该相机可用于白光成像和荧光成像，其最紧凑的形式不包含移动部件。

公开(公告)号：US20020035330A1

公开(公告)日：2002-03-21

申请号：US09905642

申请日：2001-07-13

Applicant: Xillix Technologies Corporation

Inventor： Richard W. Cline ,  John J.P. Fengler ,  Joachim W. Boehm

IPC: A61B006/00

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00186 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/2676 ,  A61B5/0084 ,  G01N21/6458 ,  G06F19/00

Abstract: A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.

Abstract translation: 荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。 来自光源的光通过内窥镜透射到观察的组织。 该系统还包括一个用于彩色和荧光成像的小型相机。 通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。 固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。 来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。 对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。 最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

公开(公告)号：US20030206301A1

公开(公告)日：2003-11-06

申请号：US10438551

申请日：2003-05-14

Applicant: Xillix Technologies Corporation

Inventor： Richard W. Cline ,  Pierre Leduc

IPC: G01N021/25

CPC classification number: A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0088

Abstract: A lightweight hand-held skin abnormality detection system includes a source of excitation light that causes tissue under examination to produce fluorescence light. The fluorescence light produced along with the beam of reference light is provided to a beam splitter which divides the fluorescence light and the reference light into separate optical channels. Each optical channel produces an image of the tissue under examination. A passive optical combiner superimposes the image produced by each optical channel for viewing by a user.

Abstract translation: 一种轻质的手持式皮肤异常检测系统，包括使检查中的组织产生荧光的激发光源。 与参考光束一起产生的荧光被提供给分束器，其将荧光和参考光分成单独的光通道。 每个光学通道产生被检查的组织的图像。 无源光学组合器叠加由每个光通道产生的图像以供用户观看。

公开(公告)号：EP0792618A1

公开(公告)日：1997-09-03

申请号：EP97300654.7

申请日：1997-01-31

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Zeng, Haishan ,  Cline, Richard W. ,  MacAulay, Calum E. ,  Jaggi, Bruno W.

IPC: A61B5/00

CPC classification number: A61B5/42 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4255

Abstract: A system for detecting cancerous or precancerous lesions directs light produced from a mercury arc lamp (100) into an illumination guide (106) of an endoscope. Autofluorescence light produced by the tissue under examination is divided into red and green spectral bands by a dichroic mirror (120). Light in the red and green spectral band is applied to a pair of image intensified CCD cameras (126, 130). The output of the camera that receives light in the red spectral band is coupled to a red video input of a color video monitor (150). Light produced by the camera that receives light in the green spectral band is coupled to the blue and green video inputs of the video monitor. The system produces a false color display, whereby healthy tissue appears cyan in color and cancerous or precancerous lesions appear reddish in color. The image displayed allows the operator to see the lesions within the context of the underlying tissue structures. The color contrast is adjustable to account for the autofluorescence property changes from patient to patient and from location to location.

Abstract translation: 一种用于检测癌症或癌前病变从汞弧灯（100）插入在内窥镜的照明引导件（106）产生的光ausrichtet系统。 由所检查的组织中产生的自发荧光的光被分成由分束器（120）的红色和绿色光谱带。 在红色和绿色光谱带的光被施加到对图像放大的CCD照相机（126，130）。 相机的输出那样接收光在红色光谱带被耦合到彩色视频监视器（150）的红色视频输入​​。 由摄像机产生的光没有接收光在绿色光谱带被耦合到视频显示器的蓝色和绿色的视频输入。 该系统产生伪色显示，由此健康组织显示于颜色和癌性或癌前病变青色颜色偏红。 显示的图像允许操作员看到下层组织结构的上下文中的病变。 颜色对比是可调节的，以考虑从患者自发荧光性质的变化对患者和从位置到位置。

公开(公告)号：EP0512965A1

公开(公告)日：1992-11-11

申请号：EP92850098.2

申请日：1992-05-05

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Jaggi, Bruno ,  Profio, Amedeus Edward ,  Macaulay, Calum ,  Lam, Stephen ,  Hung, Jaclyn

IPC: A61B5/00

CPC classification number: A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6463

Abstract: Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

Abstract translation: 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光引导件用于用至少包括激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织显着不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

公开(公告)号：EP0752825B1

公开(公告)日：2000-09-20

申请号：EP95912989.1

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： PALCIC, Branko ,  MACAULAY, Calum ,  LAM, Stephen ,  JAGGI, Bruno

IPC: A61B5/00 ,  A61B1/05

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

公开(公告)号：EP0920831A1

公开(公告)日：1999-06-09

申请号：EP99103430.7

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Macaulay, Calum ,  Lam, Stephen ,  Jaggi, Bruno

IPC: A61B1/05 ,  A61B5/00

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

Abstract translation: 用于成像组织的疾病的装置和方法被呈现。 该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。 光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。 的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。 汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。 监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。 该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。 一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。

公开(公告)号：EP0512965B1

公开(公告)日：1996-07-24

申请号：EP92850098.2

申请日：1992-05-05

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： Palcic, Branko ,  Jaggi, Bruno ,  Profio, Amedeus Edward ,  Macaulay, Calum ,  Lam, Stephen ,  Hung, Jaclyn

IPC: A61B5/00

CPC classification number: A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6463