公开(公告)号：WO1995026673A2

公开(公告)日：1995-10-12

申请号：PCT/CA1995000171

申请日：1995-03-24

Applicant: XILLIX TECHNOLOGIES CORPORATION

Inventor： XILLIX TECHNOLOGIES CORPORATION ,  PALCIC, Branko ,  MACAULAY, Calum ,  LAM, Stephen ,  JAGGI, Bruno

IPC: A61B00/00

CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

Abstract translation: 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。