公开(公告)号：US20240376213A1

公开(公告)日：2024-11-14

申请号：US18692039

申请日：2022-09-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ido AMIT ,  Rony DAHAN ,  Yuval SHAPIR ,  Oren BARBOY

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/46

Abstract: A multispecific antibody is provided. The antibody comprises a first antigen binding moiety, which specifically binds to an immune checkpoint protein on intratumor T cells and a second antigen binding moiety which specifically binds to a conventional dendritic cell 1 (cDC1). Also provided are uses of such antibodies in cancer treatment.

公开(公告)号：US20230063965A1

公开(公告)日：2023-03-02

申请号：US17794268

申请日：2021-01-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony DAHAN ,  Noy COHEN SABAN

IPC: C07K16/28 ,  A61P35/00

Abstract: An article of manufacture is provided. The article of manufacture comprising a first binding moiety which specifically binds a human FcgamaRIIB and blocks interaction with IgG antibodies and a second binding moiety which specifically binds a human PD-L1, wherein the second binding moiety which specifically binds the human PD-L1 is an antibody of a human IgG1 isotype.

公开(公告)号：US20220403043A1

公开(公告)日：2022-12-22

申请号：US17870876

申请日：2022-07-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony DAHAN ,  Ran SALOMON

IPC: C07K16/28 ,  A61P35/00

Abstract: A multispecific antibody is provided. The antibody comprising a first moiety, which binds and activates CD40, a second moiety, which specifically binds a dendritic cell (DC) and a third moiety comprising a modified Fc region of the multispecific antibody for enhancing specificity and affinity of binding to FcγRIIb and uses of same.