公开(公告)号：EP0340793B1

公开(公告)日：1995-08-30

申请号：EP89108162.2

申请日：1989-05-05

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED

Inventor： Eshhar, Zelig ,  Gross, Gideon ,  Waks, Tova

IPC: C12N5/10 ,  A61K39/00 ,  A61K35/26

CPC classification number: C07K14/7051 ,  C07K16/44 ,  C07K2317/56 ,  C07K2319/02

公开(公告)号：EP0340793A3

公开(公告)日：1991-02-27

申请号：EP89108162.2

申请日：1989-05-05

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED

Inventor： Eshhar, Zelig ,  Gross, Gideon ,  Waks, Tova

IPC: C12N5/10 ,  A61K39/00 ,  A61K35/26

CPC classification number: C07K14/7051 ,  C07K16/44 ,  C07K2317/56 ,  C07K2319/02

Abstract: There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

公开(公告)号：EP0340793A2

公开(公告)日：1989-11-08

申请号：EP89108162.2

申请日：1989-05-05

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED

Inventor： Eshhar, Zelig ,  Gross, Gideon ,  Waks, Tova

IPC: C12N5/10 ,  A61K39/00 ,  A61K35/26

CPC classification number: C07K14/7051 ,  C07K16/44 ,  C07K2317/56 ,  C07K2319/02

Abstract: There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibody molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like.
The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

Abstract translation: 产生了具有抗体型特异性的赋予单核细胞（主要是各种淋巴细胞型细胞）的重组基因对。 在特定基因对中，重排的基因对编码来自相同物种，T细胞受体基因或另一物种的抗体分子的结合位点。 本发明的基因对编码，例如针对肿瘤特异性抗原特异性的抗体，病毒抗原，修饰的自身抗原，细菌或真菌抗原，自身免疫型疾病抗原等。 本发明进一步涉及用于有效转染包含这样的重组基因对的这种细胞类型的表达载体，其生产方法和包含作为活性成分的有效量的用这种基因对转染的淋巴细胞的药物组合物。