公开(公告)号：US10689415B2

公开(公告)日：2020-06-23

申请号：US15957343

申请日：2018-04-19

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.

Inventor： Avigdor Scherz ,  Yoram Salomon ,  Efrat Rubinstein ,  Alexander Brandis ,  Doron Eren ,  Karin Neimann

IPC: A61K51/00 ,  A61M36/14 ,  C07K5/12 ,  A61K47/64 ,  C07K5/09 ,  C07K5/10 ,  C07K7/06 ,  C07K7/64 ,  A61K41/00 ,  A61K51/08 ,  G01N33/574 ,  A61K49/00

Abstract: Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.