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公开(公告)号：US11510891B2
公开(公告)日：2022-11-29
申请号：US16955087
申请日：2018-12-17
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Ezgi Avsar Apdik , Huseyin Apdik
IPC: A61K31/216 , A61K9/127
Abstract: A production of a drug, wherein the drug is specific for SH-SY5Y neuroblastoma cancer by loading caffeic acid phenethyl ester (CAPE) to a plurality of microvesicles that a specialized skin cell leaves into a nutrient solution. The objective of the present invention is to provide a cell-specific targeted vesicle development by loading the CAPE to the plurality of microvesicles obtained as a result of culturing and subsequent specialization of a plurality of tissue cells; and to use the CAPE at lower concentrations compared to a state of the art applications to minimize a toxicity of the CAPE to both a plurality of cells other than a plurality of targeted cells and a body.
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公开(公告)号：US12139415B2
公开(公告)日：2024-11-12
申请号：US17290292
申请日：2018-11-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Taha Bartu Hayal , Batuhan Turhan Bozkurt , Berna Bulbul , Seda Beyaz
Abstract: Use of nano-sized lanthanide borate (erbium borate and dysprosium borate) compounds for wound treatment due to their significant level of wound healing effect on the cells is disclosed. In the scope of the invention, the synthesis of nanometer-sized erbium borate and dysprosium borate compound by buffered-precipitation method at room conditions and the use of these compounds in biological applications are discussed.
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公开(公告)号：US11911713B2
公开(公告)日：2024-02-27
申请号：US16969997
申请日：2019-02-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Batuhan Turhan Bozkurt
CPC classification number: B01D15/34 , A61K35/16 , A61K35/20 , A61K35/22 , A61K35/38 , A61K35/50 , A61K35/52
Abstract: The present invention is an exosome isolation method for obtaining high purity exosomes inexpensively from samples of large and small amounts and types of samples from which exosomes could not be obtained before such as plant lysates. The exosome isolation method incorporates a two phase fluid extraction system, and includes the steps of isolation using dextran and PEG for removing proteins and undesired substances therein, and the steps of washing and dextran removal to collect exosomes in a pure form.
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公开(公告)号：US12138235B2
公开(公告)日：2024-11-12
申请号：US17840700
申请日：2022-06-15
Applicant: YEDITEPE UNIVERSITESI
Inventor： Fikrettin Sahin , Pakize Neslihan Tasli , Oguz Kaan Kirbas , Ezgi Avsar Apdik , Huseyin Apdik
IPC: A61K31/216 , A61K9/127
Abstract: A method of producing a caffeic acid phenethyl ester loaded microvesicular cancer drug targeting SH-SY5Y neuroblastoma cancer. The method includes seeding a plurality of skin stem cells in a medium; enabling the plurality of skin stem cells in the medium to reach a confluency of 70-80% to be seeded in a plurality of culture plates; preparing a caffeic acid phenethyl ester stock solution by dissolving the caffeic acid phenethyl ester in dimethyl sulfoxide DMSO; performing a microvesicle isolation from specialized skin cells; adding the caffeic acid phenethyl ester into a plurality of microvesicles; and separating the caffeic acid phenethyl ester loaded microvesicles from the caffeic acid phenethyl ester which is free in the solution and not loaded to a microvesicle.
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