公开(公告)号：WO1993021823A1

公开(公告)日：1993-11-11

申请号：PCT/EP1993001052

申请日：1993-04-30

Applicant: PFEIFFER, Ulrich ,  KNOLL, Reinhold

IPC: A61B05/028

CPC classification number: A61B5/411 ,  A61B5/028

Abstract: A process and device are disclosed for determining the fill level of the circulatory system of a patient, in particular the end diastolic heart volume (GEDV), the intrathoracic blood volume (ITBV), the pulmonary blood volume (PBV), the extravasal lung water volume (EVLW) and/or the global cardiac function index (CF) by thermodilution. The intrathoracic thermovolume (ITTV) and the pulmonary thermovolume (PTV) are detected, for example, and the global end diastolic heart volume (GEDV) is determined on the basis of the equation GEDV = ITTV - PTV. The remaining volumes can be calculated on the basis of these parameters, which are specific to the fill level of the heart, and of other species-specific characteristic values (a, a', b, b').

公开(公告)号：WO1997015230A1

公开(公告)日：1997-05-01

申请号：PCT/US1996017154

申请日：1996-10-25

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MCKOWN, Russell

IPC: A61B05/028

CPC classification number: A61B5/028 ,  A61B5/029 ,  A61B5/7257

Abstract: Cardiac output CO is separately estimated in a local estimator (118) and a trend estimator (120) to provide CO values. A preferably thermal indicator is injected preferably according to a pseudo-random binary sequence signal (x(t)) profile at an upstream position in a blood flow region of a patient's body and is sensed as an indicator (108) output signal (y(t)) at a downstream position. Low-frequency noise is preferably removed from the sensed indicator output signal. The local and trend estimations are based on measured frequency-domain transfer function values between the sensed and input indicator signal in relation to a pre-determined transfer function model, which is preferably a lagged normal model. The trend estimator is preferably a Kalman filter. The local estimator preferably forms its estimate based on non-recursive optimization of a cost function. The local estimator preferably provides initial values to start the trend estimator.

Abstract translation: 在局部估计器（118）和趋势估计器（120）中分别估计心输出量CO以提供CO值。 优选地，根据患者身体的血流区域中的上游位置处的伪随机二进制序列信号（x（t））轮廓注入优选的热指示器，并将其作为指示符（108）输出信号（y（ t））。 优选地，从感测到的指示符输出信号中去除低频噪声。 局部和趋势估计基于感测和输入指示符信号之间相对于预定传递函数模型的测量的频域传递函数值，其优选地是滞后的正常模型。 趋势估计器优选地是卡尔曼滤波器。 本地估计器优选地基于成本函数的非递归优化来形成其估计。 本地估计器优选地提供初始值以启动趋势估计器。

公开(公告)号：WO1991017703A1

公开(公告)日：1991-11-28

申请号：PCT/GB1991000784

申请日：1991-05-17

Applicant: CPEC CORPORATION ,  NASHEF, Samer, Abdel-Malik

Inventor： CPEC CORPORATION

IPC: A61B05/028

CPC classification number: A61B5/028

Abstract: An apparatus for measuring fluid flow rate and cardiac output comprises a support member (12, 32) having a distal end (14, 34), a proximal end (16, 36) and an outer wall (18, 38). A first temperature sensing means (20, 44) is positioned on said outer wall (18, 38) with a second temperature sensing means (22, 46) positioned on said outer wall (18, 38) proximal to said first temperature sensing means (20, 44). Heating means (24, 26, 48) is also positioned on said outer wall (18, 38) juxtaposed to said first temperature sensing means (20, 44). Thus, by energising the heating means (24, 26, 48) a temperature differential between the first and second temperature sensing means (20, 22, 44, 46) is established. The energy required to maintain the temperature differential can be controlled and monitored, and correlated to fluid flow rate and cardiac output.

Abstract translation: 用于测量流体流速和心输出量的装置包括具有远端（14,34），近端（16,36）和外壁（18,38）的支撑构件（12,32）。 第一温度感测装置（20,44）定位在所述外壁（18,38）上，第二温度感测装置（22,46）定位在靠近所述第一温度感测装置的所述外壁（18,38）上 20，44）。 加热装置（24,26,48）也位于与所述第一温度检测装置（20,44）并置的所述外壁（18,38）上。 因此，通过激励加热装置（24,26,48），建立第一和第二温度感测装置（20,22,44,46）之间的温度差。 可以控制和监测维持温差所需的能量，并与流体流速和心输出量相关。

公开(公告)号：WO1993015655A1

公开(公告)日：1993-08-19

申请号：PCT/US1993001015

申请日：1993-01-28

Applicant: INTERFLO MEDICAL INC.

Inventor： INTERFLO MEDICAL INC. ,  MCKOWN, Russell, C. ,  ECKERT, Chris ,  QUINN, Michael, D.

IPC: A61B05/028

CPC classification number: A61B5/04282 ,  A61B5/028

Abstract: Methods and apparatus for eliminating the effects of electrosurgical interference on continuous, heat-based cardiac output measurements employing several procedures, including the steps of (1) supplying power via an isolation transformer (12) and carrier frequency to a catheter-mounted heating element (16); (2) measuring the voltage and current on the primary side (10) of the isolation transformer (12); (3) determining the voltage and current on the secondary side (14) of the transformer (12) on the basis of the measured primary side voltage and current; and (4) calculating the power delivered to and resistance of the catheter-mounted heater (16) on the basis of the secondary voltage and current. A heater power waveform generated with this process will be substantially free of electrical interference due to electrosurgical devices. Then, a system transfer function may be produced via signal processing techniques which involve cross-correlating the heater power waveform with the blood temperature waveform. The system transfer function will be uncorrupted, even if the blood temperature waveform contains moderate electrical interference, since the heater power waveform is free of any correlated electrical interference.

公开(公告)号：WO1993006776A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008263

申请日：1992-09-29

Applicant: INTERFLO MEDICAL, INC.

Inventor： INTERFLO MEDICAL, INC. ,  YELDERMAN, Mark, L. ,  QUINN, Michael, D.

IPC: A61B05/028

CPC classification number: A61B18/14 ,  A61B5/028 ,  A61B5/1495 ,  A61B18/1492 ,  A61B2017/00482 ,  A61B2018/00178 ,  A61B2018/00988 ,  A61B2562/085

Abstract: A catheter assembly having a catheter (100) with at least one transducer (110) associated therewith for directly measuring physiological parameters of a patient or measuring an amount of a parameter indicative of a physiological condition of the patient and a memory (102) which resides at a predetermined location on said catheter (100). The memory (102) contains encoded calibration information for calibrating the transducers (110) and encoded patient specific information which can be accessed by an external processing system to which the catheter assembly is connected for processing. The memory (102) is further designed such that disconnection of the catheter assembly from the external processing system does not cause values stored in the memory to be lost so that the patient specific information need not be reentered into the memory when the catheter assembly is reconnected to the same or another external processing system. By so providing the catheter assembly with memory (102), information for factory calibration, patient calibration and historical patient data may be stored with the catheter (100) for ease of use. The data in the memory (102) may also be coded to prevent easy replication of the catheter (100) by a competing manufacturer.

Abstract translation: 一种具有导管（100）的导管组件，所述导管（100）具有与其相关联的至少一个换能器（110），用于直接测量患者的生理参数或测量指示患者的生理状态的参数的量以及驻留的存储器（102） 在所述导管（100）上的预定位置。 存储器（102）包含用于校准换能器（110）的编码的校准信息和编码的患者特定信息，该信息可被导管组件连接到的用于处理的外部处理系统访问。 存储器（102）被进一步设计成使得导管组件与外部处理系统的断开不会导致存储在存储器中的值丢失，使得当导管组件重新连接时不需要将患者特定信息重新进入存储器 到同一个或另一个外部处理系统。 通过为导管组件提供存储器（102），用于工厂校准，患者校准和历史患者数据的信息可以与导管（100）一起存储以便于使用。 也可以对存储器（102）中的数据进行编码，以防止竞争制造商容易地复制导管（100）。

公开(公告)号：WO1998014114A1

公开(公告)日：1998-04-09

申请号：PCT/US1997017064

申请日：1997-09-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MOONEY, Charles, R. ,  KONNO, Mark, A. ,  MINOT, Mark, M. ,  PHAN, Luong, N. ,  ROTELIUK, Luchy, D.

IPC: A61B05/028

CPC classification number: A61B5/028 ,  G01F1/68 ,  G01F1/684

Abstract: A catheter (20) includes a body portion (22) having a distal end (24) and a proximal end (26). A plurality of lumens (28) are formed in the body portion between the distal and proximal ends. A heating element (30) and a temperature sensor (32) are disposed on the catheter, with the temperature sensor being positioned between the heating element and the distal end of the body portion. Heating-element wires (34) are connected to the heating element and extend from the heating element to the proximal end of the body portion in one of the lumens of the catheter, and temperature-sensor wires are connected to the temperature sensor and extend in a twisted configuration from the temperature sensor to the proximal end of the body portion in one of the lumens of the catheter. The heating-element wires are connectable to a control unit (68) and carry an activation signal from the control unit to the heating element to activate the heating element. The temperature-sensor wires are connectable to a processing unit (70) and carry a temperature-sensor signal from the temperature sensor to the processing unit for processing.

Abstract translation: 导管（20）包括具有远端（24）和近端（26）的主体部分（22）。 多个管腔（28）形成在远端和近端之间的主体部分中。 在导管上设置加热元件（30）和温度传感器（32），其中温度传感器位于加热元件和主体部分的远端之间。 加热元件线（34）连接到加热元件并且在导管的一个管腔中从加热元件延伸到主体部分的近端，并且温度传感器线连接到温度传感器并且在 在导管的一个管腔中从温度传感器到主体部分的近端的扭转构造。 加热元件线可连接到控制单元（68），并将启动信号从控制单元传送到加热元件以激活加热元件。 温度传感器线可连接到处理单元（70），并将温度传感器信号从温度传感器传送到处理单元进行处理。

公开(公告)号：WO1997048334A1

公开(公告)日：1997-12-24

申请号：PCT/IB1997000751

申请日：1997-06-16

Applicant: ENDRYS, Jiri

IPC: A61B05/028

CPC classification number: A61B5/028

Abstract: The present invention relates to an apparatus (40) for detecting and determining the magnitude of intracardiac shunts by the use of thermodilution. Two thermodilution curves are measured from different parts of the heart. The presence of an intracardiac shunt is detected by comparing (48) the shapes of the measured thermodilution curves with the shape of thermodilution curves obtained from a heart without a shunt. To determine the magnitude of an intracardiac shunt the areas below the measured thermodilution curves are calculated (52). This area-information is used for calculation (52) of the cardiac output and then the magnitude of the shunt.

Abstract translation: 本发明涉及一种用于通过使用热稀释来检测和确定心脏内分流的大小的装置（40）。 从心脏的不同部位测量两种热稀释曲线。 通过比较（48）测量的热稀释曲线的形状与从没有分流的心脏获得的热稀释曲线的形状来检测心内分流的存在。 为了确定心脏内分流的大小，计算出测量的热稀释曲线以下的区域（52）。 该区域信息用于心输出量的计算（52），然后用于分流的大小。

公开(公告)号：WO1992017111A1

公开(公告)日：1992-10-15

申请号：PCT/US1992002414

申请日：1992-03-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  WOLZINGER, Renah ,  WU, Su, Syin, Soong

IPC: A61B05/028

CPC classification number: A61B5/028 ,  A61B2018/00166

Abstract: A catheter (11) for measuring the temperature of a fluid in a living body comprising an elongated tube (13) having at least one lumen extending longitudinally within the tube (13) and an opening (61) in a peripheral wall of the tube (13). A thermistor mounting body (63) mounts a thermistor (57) in the lumen (30) adjacent the opening. The thermistor mounting body (63) defines a cavity (67) at the opening (61) which opens radially outwardly, and the thermistor (57) is partially within the mounting body (63) and projects from the mounting body (63) into the cavity (67). There is at least one conductor (49) in the tube (13) with at least a region of the conductor (49) extending longitudinally of the lumen (29) from a location proximally of the thermistor (57) to a location at which the conductor (49) is electrically coupled to the thermistor (57). The mounting body (63) may include a matrix of electrical insulating material and a filler carried by the matrix, with the filler being more thermally conductive than the electrical insulating material. In addition, by providing a multi-lumen cathetter, certain of the lumens (25, 27, 29) can be used to thermally insulate the thermistor (57) from any lumen adapted to carry fluid past the location of the thermistor (57) in the catheter (11).

公开(公告)号：WO1997048335A1

公开(公告)日：1997-12-24

申请号：PCT/IB1997000752

申请日：1997-06-16

Applicant: ENDRYS, Jiri

IPC: A61B05/028

CPC classification number: A61B5/028

Abstract: The present invention relates to an apparatus (10) for the detection and determination of the magnitude of the regurgitant flow of blood across a heart valve by the use of thermodilution. Two thermodilution curves are measured from different parts of the heart, i.e. upstream and downstream the valve. The presence of valvular regurgitation is indicated by detection (18) of the presence of a temprature decrease upstream the valve. The areas below the thermodilution curves are calculated (20) in the first place, and this area information is used for the calculation (20) of the cardiac output and then the magnitude of the regurgitant flow.

Abstract translation: 本发明涉及一种用于通过使用热稀释来检测和确定穿过心脏瓣膜的血液反流量的大小的装置（10）。 从心脏的不同部分，即阀的上游和下游测量两个热稀释曲线。 通过检测（18）在瓣膜上游存在温度降低来表示瓣膜反流的存在。 热稀释曲线下面的区域首先计算（20），该区域信息用于心输出量的计算（20），然后用于反流量的大小。

公开(公告)号：WO1996032056A3

公开(公告)日：1996-10-17

申请号：PCT/BE1996000043

申请日：1996-04-15

Applicant: BILLIET, Erik

IPC: A61B05/028