公开(公告)号：US11535648B2

公开(公告)日：2022-12-27

申请号：US17260934

申请日：2019-05-17

Applicant: Northeastern University

Inventor： Kim Lewis ,  Yu Imai ,  Quentin Favre-Godal ,  Akira Iinishi ,  Kirsten Meyer

IPC: C07K7/06 ,  A61P31/04 ,  A61K45/06

Abstract: Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria.

公开(公告)号：US12247245B2

公开(公告)日：2025-03-11

申请号：US17262031

申请日：2019-05-24

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Kim Lewis ,  Anthony D'Onofrio ,  Thomas Curtis ,  Charlotte Berkes

IPC: C12Q1/18

Abstract: Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof. The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated.

公开(公告)号：US20240002442A1

公开(公告)日：2024-01-04

申请号：US18254459

申请日：2021-11-24

Applicant: Northeastern University

Inventor： Kim Lewis ,  Ryan Miller ,  Akira Iinishi ,  Patrick James Lariviere ,  Thomas Curtis

IPC: C07K7/64 ,  A01N63/50 ,  A01P1/00

CPC classification number: C07K7/64 ,  A01N63/50 ,  A01P1/00 ,  A61K38/00

Abstract: Novel compounds and analogues that exhibit antimicrobial activity—particularly against Gram-negative pathogens—are producible from bacterial isolate Photorhabdus australis DSM 17609 and some related bacterial species of the genus. Pharmaceutical compositions containing the novel compound and its analogues are useful for treating or preventing a bacterial infection. Compounds in accordance herewith include ribosomally produced and post-translationally modified cyclic peptides useful for the treatment, amelioration, and prevention of bacterial infections by Gram-negative pathogens, in addition to other indications.

公开(公告)号：US20160074379A1

公开(公告)日：2016-03-17

申请号：US14949382

申请日：2015-11-23

Applicant: Northeastern University ,  The General Hospital Corporation

Inventor： Terence Moy ,  Annie Conery ,  Kim Lewis ,  Frederick M. Ausubel ,  Read Pukkila-Worley

IPC: A61K31/47

CPC classification number: A61K31/47 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4725 ,  A61K31/501 ,  Y02A50/473

Abstract: This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.

Abstract translation: 本公开涉及包含通过定量，高通量测定鉴定的某些化合物的组合物，以有效抑制细菌杀死宿主生物的能力，以及使用这些化合物治疗细菌感染的方法。

公开(公告)号：US20140199372A1

公开(公告)日：2014-07-17

申请号：US14119566

申请日：2012-05-24

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Kim Lewis ,  Pallavi Murugkar ,  Anthony D'onofrio ,  Eric Stewart ,  Eric Dimise ,  Jon Clardy ,  Kathrin Witt ,  Bijaya Sharma

IPC: C12N1/38 ,  A61K9/127 ,  A61K35/74 ,  A61K31/122

CPC classification number: C12N1/38 ,  A61K9/127 ,  A61K31/122 ,  A61K35/741 ,  C12N1/20 ,  Y02A50/473

Abstract: Disclosed are methods of cultivating or isolating a microorganism using one or more quinones as growth factors. Also disclosed are methods of treating a mammalian species with deficiency in symbionts using such compounds.

Abstract translation: 公开了使用一种或多种醌作为生长因子来培养或分离微生物的方法。 还公开了使用这种化合物处理共生体缺乏的哺乳动物物种的方法。

公开(公告)号：US20230090435A1

公开(公告)日：2023-03-23

申请号：US18056346

申请日：2022-11-17

Applicant: Northeastern University

Inventor： Kim Lewis ,  Yu imai ,  Quentin Favre-Godal ,  Akira Iinishi ,  Kirsten Meyer

IPC: C07K7/06 ,  A61P31/04 ,  A61K45/06

Abstract: Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria.

公开(公告)号：US20210261616A1

公开(公告)日：2021-08-26

申请号：US17260934

申请日：2019-05-17

Applicant: Northeastern University

Inventor： Kim Lewis ,  Yu Imai ,  Quentin Favre-Godal ,  Akira Iinishi ,  Kirsten Meyer

IPC: C07K7/06 ,  A61K45/06 ,  A61P31/04

Abstract: Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria.

公开(公告)号：US20240287139A1

公开(公告)日：2024-08-29

申请号：US18571666

申请日：2022-06-23

Applicant: Northeastern University

Inventor： Kim Lewis ,  Yu Imai

IPC: C07K11/02 ,  A01N63/50 ,  A61K38/00 ,  A61K38/15 ,  A61K45/06 ,  A61P31/06

CPC classification number: C07K11/02 ,  A01N63/50 ,  A61K38/15 ,  A61K45/06 ,  A61P31/06 ,  A61K38/00

Abstract: The present invention directed to a novel macrocyclic depsipeptide compound, its derivatives, and their pharmaceutically acceptable salts, having selective antibacterial activity against M. tuberculosis.