公开(公告)号：US12247245B2

公开(公告)日：2025-03-11

申请号：US17262031

申请日：2019-05-24

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Kim Lewis ,  Anthony D'Onofrio ,  Thomas Curtis ,  Charlotte Berkes

IPC: C12Q1/18

Abstract: Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof. The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated.

公开(公告)号：US20240002442A1

公开(公告)日：2024-01-04

申请号：US18254459

申请日：2021-11-24

Applicant: Northeastern University

Inventor： Kim Lewis ,  Ryan Miller ,  Akira Iinishi ,  Patrick James Lariviere ,  Thomas Curtis

IPC: C07K7/64 ,  A01N63/50 ,  A01P1/00

CPC classification number: C07K7/64 ,  A01N63/50 ,  A01P1/00 ,  A61K38/00

Abstract: Novel compounds and analogues that exhibit antimicrobial activity—particularly against Gram-negative pathogens—are producible from bacterial isolate Photorhabdus australis DSM 17609 and some related bacterial species of the genus. Pharmaceutical compositions containing the novel compound and its analogues are useful for treating or preventing a bacterial infection. Compounds in accordance herewith include ribosomally produced and post-translationally modified cyclic peptides useful for the treatment, amelioration, and prevention of bacterial infections by Gram-negative pathogens, in addition to other indications.