公开(公告)号：US20230058111A1

公开(公告)日：2023-02-23

申请号：US17880404

申请日：2022-08-03

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Aurèle Timothée Horisberger ,  Andrey Naumenko ,  Diego Joss

IPC: G02B21/00

Abstract: In some embodiments, a method provides a live view mode without scanning a micro optical element array in which successive image(s) are generated, and optionally displayed, that comprise image pixels that represent sample light received from micro optical elements in an array for different, spatially distinct locations in a sample. Images can be of a useful size and resolution to obtain information indicative of a real time sample state. A full image acquisition by scanning a micro optical element array may be initiated when a sample has sufficiently (self-) stabilized. In some embodiments, a method provides images including a stabilization index without scanning a micro optical element array. A stabilization index that represents an empirically derived quantitative assessment of a degree of stabilization may be determined (e.g., calculated) for sample light received from for one or more micro optical elements each represented by one or more image pixels in an image.

公开(公告)号：US11333875B2

公开(公告)日：2022-05-17

申请号：US17141933

申请日：2021-01-05

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Jonathan Abel Pirolet ,  Frédéric Schmitt ,  Bastien Rachet ,  Diego Joss ,  Aurèle Timothée Horisberger

IPC: G02B21/34 ,  G01N21/01 ,  G01N21/64 ,  G02B21/36

Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.

公开(公告)号：US11181728B2

公开(公告)日：2021-11-23

申请号：US17006235

申请日：2020-08-28

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Bastien Rachet ,  Aurèle Timothée Horisberger ,  Jonathan Abel Pirolet ,  Diego Joss ,  Andrey Naumenko ,  Frédéric Schmitt

IPC: G02B21/06 ,  G02B21/36 ,  G02B21/00 ,  A61B90/20 ,  G01N21/64 ,  G02B21/08 ,  G02B21/16 ,  H04N5/225 ,  H04N7/18

Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.

公开(公告)号：US10928621B2

公开(公告)日：2021-02-23

申请号：US16146518

申请日：2018-09-28

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Jonathan Abel Pirolet ,  Frédéric Schmitt ,  Bastien Rachet ,  Diego Joss ,  Aurèle Timothée Horisberger

IPC: G02B21/34 ,  G01N21/01 ,  G01N21/64 ,  G02B21/36

Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.

公开(公告)号：US20200309649A1

公开(公告)日：2020-10-01

申请号：US16806536

申请日：2020-03-02

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Aurèle Timothée Horisberger ,  Frédéric Schmitt ,  Bastien Rachet

IPC: G01N1/31

Abstract: Disclosed herein are receptacles for use in staining and/or rinsing samples. In some embodiments, a receptacle includes a container and a container top. A container may be sized and shaped to contain fluid and a sample submerged in the fluid. The fluid may be, for example, staining agent solution or rinsing solution. In some embodiments, a kit is provided that includes a first receptacle that includes a container partially filled with staining agent solution and a second receptacle that includes a container partially filled with rinsing solution. In some embodiments, a receptacle includes a container and a basket that is positionable in the container. A basket may include a permeable sample holding element that is permeable to fluid in a container so that samples can be sufficiently stained or rinsed. In some embodiments, a receptacle is a single-dose receptacle that is used intraoperatively (e.g., in an operating room).

公开(公告)号：US10088427B2

公开(公告)日：2018-10-02

申请号：US15087601

申请日：2016-03-31

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N21/77 ,  G02B21/00 ,  G01N21/64 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G01N33/483 ,  G02B21/16 ,  G02B21/24

Abstract: The disclosed technology brings histopathology into the operating theater, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theater, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US20250148606A1

公开(公告)日：2025-05-08

申请号：US19011901

申请日：2025-01-07

Applicant: SamanTree Medical SA

Inventor： Andrey Naumenko ,  Aurèle Timothée Horisberger ,  Diego Joss ,  Frédéric Schmitt ,  Etienne Shaffer ,  Jonathan Abel Pirolet ,  Bastien Rachet ,  Andrew Logvinov

IPC: G06T7/00 ,  G01N33/483 ,  G02B21/00 ,  G02B21/36 ,  G06T3/4038

Abstract: Systems and methods to identify and/or reduce or eliminate sample motion artifacts are disclosed. Sample motion artifacts may be reduced or eliminated using scan patterns where an acquisition time difference between when perimeter pixels in adjacent tiles are acquired is reduced, as compared to a conventional raster scan to reduce or eliminate discontinuities that would otherwise appear at tile boundaries in an image. In some embodiments, test images acquired using relatively small test scan patterns or intensities of test points acquired at different times may be compared to determine whether sample motion has occurred. In some embodiments, intensity of adjacent pixels at a tile boundary are compared. In some embodiments, intensity of one or more single pixels is monitored over time to determine whether sample motion has occurred over a period of time. In some embodiments, a flattening or reshaping tool may be used to suppress sample motion during imaging.

公开(公告)号：US20240264422A1

公开(公告)日：2024-08-08

申请号：US18607993

申请日：2024-03-18

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Jonathan Abel Pirolet ,  Frédéric Schmitt ,  Bastien Rachet ,  Diego Joss ,  Aurèle Timothée Horisberger

IPC: G02B21/34 ,  G01N21/01 ,  G01N21/64 ,  G02B21/36

CPC classification number: G02B21/34 ,  G01N21/01 ,  G01N21/6428 ,  G02B21/367

Abstract: Disclosed herein are sample dishes for use with microscopes that are simple to mount on a microscope and facilitate easy manipulation of tissue samples disposed thereon during imaging as well as methods of their use. A sample dish comprises an optical interface and, optionally, a support member that holds the optical interface. The optical interface of a sample dish is suitably transparent and planar such that a focal plane of a microscope can reside uniformly at or within a surface of a sample during imaging. In certain embodiments, a support member comprises a dish for holding excess fluid. In certain embodiments, a sample dish comprises separation ribs. In certain embodiments, a sample dish comprises one or more manipulation members (e.g., tabs). In certain embodiments, a sample dish is used with an imaging artifact reducing fluid.

公开(公告)号：US11828710B2

公开(公告)日：2023-11-28

申请号：US18103069

申请日：2023-01-30

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G02B21/00 ,  G01N21/77 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G01N21/64 ,  G01N33/483 ,  G02B21/16 ,  G02B21/24

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G02B21/004 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0633 ,  G02B21/0012 ,  G02B21/0044 ,  G02B21/24

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US10816788B2

公开(公告)日：2020-10-27

申请号：US16593726

申请日：2019-10-04

Applicant: SamanTree Medical SA

Inventor： Etienne Shaffer ,  Bastien Rachet ,  Aurèle Timothée Horisberger ,  Jonathan Abel Pirolet ,  Diego Joss ,  Frédéric Schmitt

IPC: G01J3/46 ,  G02B21/36 ,  G02B21/00 ,  A61B90/20 ,  G01N21/64 ,  G02B21/08 ,  G02B21/16 ,  H04N5/225 ,  H04N7/18

Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.