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    Diagnostic method and system with optical and temperature sensors for imaging and mapping fluorescence intensities of tissue
    3.
    发明授权
    Diagnostic method and system with optical and temperature sensors for imaging and mapping fluorescence intensities of tissue 有权

    公开(公告)号：US12251191B2

    公开(公告)日：2025-03-18

    申请号：US17856487

    申请日：2022-07-01

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.

    PORTABLE IMAGING DEVICES AND SYSTEMS FOR REAL-TIME VISUALIZATION OF BACTERIA AND RELATED METHODS
    4.
    发明申请
    PORTABLE IMAGING DEVICES AND SYSTEMS FOR REAL-TIME VISUALIZATION OF BACTERIA AND RELATED METHODS 有权

    公开(公告)号：US20240366090A1

    公开(公告)日：2024-11-07

    申请号：US18662750

    申请日：2024-05-13

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A portable imaging system for visualizing bacteria in a wound in real time includes an excitation light source configured to emit violet and/or blue excitation light to illuminate a wound and cause at least one biomarker associated with the wound to fluoresce and a camera configured to detect fluorescence emitted by the at least one biomarker associated with the wound in response to illumination of the wound with the excitation light. A portable frame is configured to support the camera and the excitation light source for hands-free operation and to position the camera and the excitation light source relative to the wound. The system also includes a power source for the excitation light source.

    Devices, methods, and systems with spectral filtering for detecting wound and identifying bacteria based on fluorescence signature
    9.
    发明授权
    Devices, methods, and systems with spectral filtering for detecting wound and identifying bacteria based on fluorescence signature 有权

    公开(公告)号：US12226186B2

    公开(公告)日：2025-02-18

    申请号：US17193318

    申请日：2021-03-05

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.

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