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1.发明授权公开(公告)号：US11662315B2
公开(公告)日：2023-05-30
申请号：US17516490
申请日：2021-11-01
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01B11/22 , G01N21/64 , G01N21/47 , G01N33/483
CPC classification number: G01N21/6456 , G01B11/22 , G01N21/4795 , G01N33/4833 , G01N2201/062
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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2.发明申请公开(公告)号：US20210239617A1
公开(公告)日：2021-08-05
申请号：US17050745
申请日：2019-04-26
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01N21/64 , G01N33/483 , G01B11/22 , G01N21/47
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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公开(公告)号：US11977027B2
公开(公告)日：2024-05-07
申请号：US18202823
申请日：2023-05-26
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01B11/22 , G01N21/47 , G01N21/64 , G01N33/483
CPC classification number: G01N21/6456 , G01B11/22 , G01N21/4795 , G01N33/4833 , G01N2201/062
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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Patent Agency Ranking
公开(公告)号：US20230324301A1
公开(公告)日：2023-10-12
申请号：US18202823
申请日：2023-05-26
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01N21/64 , G01N21/47 , G01B11/22 , G01N33/483
CPC classification number: G01N21/6456 , G01B11/22 , G01N21/4795 , G01N33/4833 , G01N2201/062
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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5.发明授权公开(公告)号：US11162900B2
公开(公告)日：2021-11-02
申请号：US17050745
申请日：2019-04-26
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01N21/64 , G01N33/483 , G01N21/47 , G01B11/22
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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公开(公告)号：US20150148629A1
公开(公告)日：2015-05-28
申请号：US14367829
申请日：2012-12-21
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Brian C. Wilson , Anthony Taywon Kim , Pablo A. Valdes , Keith D. Paulsen , David W. Roberts
IPC: A61B19/00 , A61B5/1459 , A61K49/00 , A61B5/00 , A61B10/04 , A61B5/145 , A61B10/02 , A61B5/1455
CPC classification number: A61B34/20 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B5/489 , A61B5/6848 , A61B10/0275 , A61B10/04 , A61B17/3403 , A61B90/11 , A61B2010/0208 , A61B2010/045 , A61B2034/2055 , A61B2090/3945 , A61K49/0017 , F04C2270/041
Abstract: An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.
Abstract translation: 一种用于提供机械活检程序的光谱引导的光学光谱探针和包括光学光谱探针的组织活检装置。 光学光谱探测器可定位在机械活检装置的内腔中。 探针可以实现活检程序中的光谱学指导，包括脑活检程序。
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7.发明申请公开(公告)号：US20220057328A1
公开(公告)日：2022-02-24
申请号：US17516490
申请日：2021-11-01
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01N21/64 , G01B11/22 , G01N21/47 , G01N33/483
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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公开(公告)号：US09763744B2
公开(公告)日：2017-09-19
申请号：US14367829
申请日：2012-12-21
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Brian C. Wilson , Anthony Taywon Kim , Pablo A. Valdes , Keith D. Paulsen , David W. Roberts
IPC: A61B6/00 , A61B19/00 , A61B10/02 , A61B17/34 , A61B5/00 , A61B5/1459 , A61B5/145 , A61B5/1455 , A61B10/04 , A61K49/00 , A61B34/20 , A61B90/00 , A61B90/11
CPC classification number: A61B34/20 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B5/489 , A61B5/6848 , A61B10/0275 , A61B10/04 , A61B17/3403 , A61B90/11 , A61B2010/0208 , A61B2010/045 , A61B2034/2055 , A61B2090/3945 , A61K49/0017 , F04C2270/041
Abstract: An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.
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