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    Diagnostic method and system with optical and temperature sensors for imaging and mapping fluorescence intensities of tissue
    3.
    发明授权
    Diagnostic method and system with optical and temperature sensors for imaging and mapping fluorescence intensities of tissue 有权

    公开(公告)号：US12251191B2

    公开(公告)日：2025-03-18

    申请号：US17856487

    申请日：2022-07-01

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.

    PORTABLE IMAGING DEVICES AND SYSTEMS FOR REAL-TIME VISUALIZATION OF BACTERIA AND RELATED METHODS
    4.
    发明申请
    PORTABLE IMAGING DEVICES AND SYSTEMS FOR REAL-TIME VISUALIZATION OF BACTERIA AND RELATED METHODS 有权

    公开(公告)号：US20240366090A1

    公开(公告)日：2024-11-07

    申请号：US18662750

    申请日：2024-05-13

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A portable imaging system for visualizing bacteria in a wound in real time includes an excitation light source configured to emit violet and/or blue excitation light to illuminate a wound and cause at least one biomarker associated with the wound to fluoresce and a camera configured to detect fluorescence emitted by the at least one biomarker associated with the wound in response to illumination of the wound with the excitation light. A portable frame is configured to support the camera and the excitation light source for hands-free operation and to position the camera and the excitation light source relative to the wound. The system also includes a power source for the excitation light source.

    Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria
    7.
    发明授权
    Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria 有权

    公开(公告)号：US11375898B2

    公开(公告)日：2022-07-05

    申请号：US14719493

    申请日：2015-05-22

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

    Abstract: A system for acquiring data regarding a wound in tissue comprises at least one light source configured to directly illuminate a target surface with a homogeneous field of excitation light. An optical sensor is configured to detect signals responsive to illumination of an illuminated portion of a wound and the area around the wound. A thermal sensor is configured to detect thermal information regarding the illuminated portion of the wound and the area around the wound. A processor receives the detected signals and the detected thermal information and outputs data regarding the illuminated portion of the wound and the area around the wound. The output data may include wound size of the illuminated portion of the wound, bacterial load of the illuminated portion of the wound, or at least one temperature associated with the illuminated portion of the wound and the area around the wound. The data output by the processor may be displayed on a display of the system.

    DEVICES, METHODS, AND SYSTEMS FOR DETECTING AND IDENTIFYING BACTERIA BASED ON FLUORESCENCE SIGNATURE
    8.
    发明申请
    DEVICES, METHODS, AND SYSTEMS FOR DETECTING AND IDENTIFYING BACTERIA BASED ON FLUORESCENCE SIGNATURE 有权

    公开(公告)号：US20210259552A1

    公开(公告)日：2021-08-26

    申请号：US17193318

    申请日：2021-03-05

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  G01N21/64 ,  A61B5/01

    Abstract: A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.

    Method and System for Imaging and Collection of Data for Diagnostic Purposes
    9.
    发明申请
    Method and System for Imaging and Collection of Data for Diagnostic Purposes 审中-公开
    用于诊断用途的数据成像和收集方法和系统

    公开(公告)号：US20160045114A1

    公开(公告)日：2016-02-18

    申请号：US14719493

    申请日：2015-05-22

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01

    Abstract: A system for acquiring data regarding a wound in tissue comprises at least one light source configured to directly illuminate a target surface with a homogeneous field of excitation light. An optical sensor is configured to detect signals responsive to illumination of an illuminated portion of a wound and the area around the wound. A thermal sensor is configured to detect thermal information regarding the illuminated portion of the wound and the area around the wound. A processor receives the detected signals and the detected thermal information and outputs data regarding the illuminated portion of the wound and the area around the wound. The output data may include wound size of the illuminated portion of the wound, bacterial load of the illuminated portion of the wound, or at least one temperature associated with the illuminated portion of the wound and the area around the wound. The data output by the processor may be displayed on a display of the system.

    Abstract translation: 用于获取关于组织中的伤口的数据的系统包括被配置为用均匀的激发光场直接照射目标表面的至少一个光源。 光学传感器被配置为检测响应于伤口的照射部分和伤口周围区域的照明的信号。 热传感器被配置为检测关于伤口的照射部分和伤口周围区域的热信息。 处理器接收检测到的信号和检测到的热信息，并输出关于伤口的照射部分和伤口周围区域的数据。 输出数据可以包括伤口的照射部分的伤口尺寸，伤口的照射部分的细菌负荷或与伤口的照射部分和伤口周围区域相关联的至少一个温度。 处理器输出的数据可以显示在系统的显示器上。

    Devices, methods, and systems for fluorescence-based endoscopic imaging and collection of data with optical filters with corresponding discrete spectral bandwidth
    10.
    发明授权
    Devices, methods, and systems for fluorescence-based endoscopic imaging and collection of data with optical filters with corresponding discrete spectral bandwidth 有权

    公开(公告)号：US11284800B2

    公开(公告)日：2022-03-29

    申请号：US15965462

    申请日：2018-04-27

    Applicant: University Health Network

    Inventor： Ralph Dacosta ,  Brian C. Wilson ,  Kai Zhang

    IPC: A61B5/00 ,  A61B5/01 ,  G01N21/64 ,  A61B10/00

    Abstract: A portable, handheld device for fluorescence-based imaging is provided. The device comprises a wireless communication device having a sensor configured to detect optical signals. The device further comprises an assembly configured to receive and secure the wireless communication device therein. The assembly includes a housing, at least one light source coupled to the housing, a power supply, and an optical filter holder coupled to the housing and configured to receive one or more optical filters. An endoscope portion of the device is positioned relative to the sensor to visualize at least a portion of a confined anatomical space and to receive optical signals from a visualized, illuminated portion of a target positioned within the confined anatomical space. A processor of the device includes image analysis software and is configured to produce a composite representation of the illuminated portion of the target positioned within the confined anatomical space.

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