公开(公告)号：US11676276B2

公开(公告)日：2023-06-13

申请号：US16593174

申请日：2019-10-04

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Dacosta

IPC: G06T7/00 ,  A61B5/00 ,  G01N21/64

CPC classification number: G06T7/0016 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/445 ,  G01N21/6486 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/10064 ,  G06T2207/30088 ,  G06T2207/30096

Abstract: Systems and methods for obtaining diagnostic data of a target are disclosed. The systems include an imaging device and a drape. The imaging device includes at least one excitation light source for fluorescent imaging, and an optical sensor configured to detect signals responsive to illumination of the target with the excitation light. The drape is configured to reduce ambient light surrounding the target during imaging.

公开(公告)号：US11961236B2

公开(公告)日：2024-04-16

申请号：US18334123

申请日：2023-06-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Dacosta

IPC: G06T7/00 ,  A61B5/00 ,  G01N21/64

CPC classification number: G06T7/0016 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/445 ,  G01N21/6486 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/10064 ,  G06T2207/30088 ,  G06T2207/30096

Abstract: Systems and methods for determining bacterial load in targets are disclosed. An autofluorescence detection and collection device includes a light source configured to illuminate a target with excitation light causing at least one biomarker in the illuminated target to fluoresce. Bacterial autofluorescence data regarding the target is collected and analyzed to determine bacterial load the target. The autofluorescence data may be analyzed using pixel intensity.

公开(公告)号：US10438356B2

公开(公告)日：2019-10-08

申请号：US15328214

申请日：2015-07-24

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Dacosta

IPC: A61B5/00 ,  G06T7/00 ,  G01N21/64

Abstract: Systems and methods for determining bacterial load in targets and tracking changes in bacterial load of targets over time are disclosed. An autofluorescence detection and collection device includes a light source configured to directly illuminate at least a portion of a target and an area around the target with excitation light causing at least one biomarker in the illuminated target to fluoresce. Bacterial autofluorescence data regarding the illuminated portion of the target and the area around the target is collected and analyzed to determine bacterial load of the illuminated portion of the target and area around the target. The autofluorescence data may be analyzed using pixel intensity. Changes in bacterial load of the target over time may be tracked. The target may be a wound in tissue.

公开(公告)号：US12169935B2

公开(公告)日：2024-12-17

申请号：US18334133

申请日：2023-06-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Dacosta

IPC: G06T7/00 ,  A61B5/00 ,  G01N21/64

Abstract: A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.

公开(公告)号：US11284800B2

公开(公告)日：2022-03-29

申请号：US15965462

申请日：2018-04-27

Applicant: University Health Network

Inventor： Ralph Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  G01N21/64 ,  A61B10/00

Abstract: A portable, handheld device for fluorescence-based imaging is provided. The device comprises a wireless communication device having a sensor configured to detect optical signals. The device further comprises an assembly configured to receive and secure the wireless communication device therein. The assembly includes a housing, at least one light source coupled to the housing, a power supply, and an optical filter holder coupled to the housing and configured to receive one or more optical filters. An endoscope portion of the device is positioned relative to the sensor to visualize at least a portion of a confined anatomical space and to receive optical signals from a visualized, illuminated portion of a target positioned within the confined anatomical space. A processor of the device includes image analysis software and is configured to produce a composite representation of the illuminated portion of the target positioned within the confined anatomical space.

公开(公告)号：US10780164B2

公开(公告)日：2020-09-22

申请号：US15301682

申请日：2015-04-07

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  UNIVERSITY HEALTH NETWORK

Inventor： Xiaoyu Wu ,  Claudia Regina Gordijo ,  Azhar Z. Abbasi ,  Preethy Prasad ,  Ralph Dacosta ,  Azusa Maeda ,  Mohammad Ali Amini

IPC: A61K41/00 ,  A61N5/10 ,  A61K9/14 ,  C01G45/02 ,  A61K9/00 ,  A61K9/51 ,  A61K33/32 ,  A61K47/32 ,  A61K47/34 ,  A61K47/42

Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.