公开(公告)号：US11890233B2

公开(公告)日：2024-02-06

申请号：US16839333

申请日：2020-04-03

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Jinglin Huang

IPC: A61F9/04 ,  A61F9/00 ,  A61M31/00

CPC classification number: A61F9/04 ,  A61F9/0017 ,  A61M31/00 ,  A61M2205/3368 ,  A61M2205/3626 ,  A61M2210/0612

Abstract: Disclosed are example embodiments of methods and systems for inducing drug to thoroughly mix in a patient's vitreous humor. One of the systems includes: a heat transfer pad that transfer heat to or from the eyeball; and a control module electronically coupled to the heat transfer pad for controlling one or more heat transfer elements disposed thereon.

公开(公告)号：US11890097B2

公开(公告)日：2024-02-06

申请号：US17179018

申请日：2021-02-18

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Shane S. Shahrestani

IPC: A61B5/245 ,  A61B5/00 ,  A61B5/06

CPC classification number: A61B5/245 ,  A61B5/067 ,  A61B5/4839 ,  A61B5/6803 ,  A61B5/684 ,  A61B5/7246 ,  A61B2562/0223

Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

公开(公告)号：US20240033341A1

公开(公告)日：2024-02-01

申请号：US18340008

申请日：2023-06-22

Applicant: California Institute of Technology ,  THE ROCKEFELLER UNIVERSITY

Inventor： Harry Gristick ,  Pamela J. Bjorkman ,  Harald Hartweger ,  Michel C. Nussenzweig

IPC: A61K39/21 ,  A61P37/04

CPC classification number: A61K39/21 ,  A61P37/04 ,  A61K2039/545

Abstract: Provided herein are HIV immunogens and uses thereof for generating an immune response in a subject. This disclosure further provides a method for treating or preventing a human immunodeficiency type I (HIV-I) infection in a subject using the disclosed HIV immunogens and/or antibodies generated by any of the methods disclosed herein.

公开(公告)号：US11881581B2

公开(公告)日：2024-01-23

申请号：US17541838

申请日：2021-12-03

Applicant: HONDA MOTOR CO., LTD. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Nam Hawn Chou ,  Kaoru Omichi ,  Ryan McKenney ,  Qingmin Xu ,  Christopher Brooks ,  Simon C. Jones ,  Isabelle M. Darolles ,  Hongjin Tan

IPC: H01M4/04 ,  H01M4/36 ,  H01M4/1395 ,  H01M4/134 ,  H01M4/62 ,  H01M4/38 ,  H01M4/58

CPC classification number: H01M4/366 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/38 ,  H01M4/582 ,  H01M4/62

Abstract: The present disclosure relates to a method of making core-shell and yolk-shell nanoparticles, and to electrodes comprising the same. The core-shell and yolk-shell nanoparticles and electrodes comprising them are suitable for use in electrochemical cells, such as fluoride shuttle batteries. The shell may protect the metal core from oxidation, including in an electrochemical cell. In some embodiments, an electrochemically active structure includes a dimensionally changeable active material forming a particle that expands or contracts upon reaction with or release of fluoride ions. One or more particles are at least partially surrounded with a fluoride-conducting encapsulant and optionally one or more voids are formed between the active material and the encapsulant using sacrificial layers or selective etching. When the electrochemically active structures are used in secondary batteries, the presence of voids can accommodate dimensional changes of the active material.

公开(公告)号：US11879143B2

公开(公告)日：2024-01-23

申请号：US16691452

申请日：2019-11-21

Applicant: California Institute of Technology

Inventor： Andrew Richard Buller ,  Sabine Brinkmann-Chen ,  Michael Herger ,  David K. Romney ,  Javier Murciano Calles ,  Paul van Roye

IPC: C12P13/22 ,  C12N9/88 ,  C12P13/04

CPC classification number: C12P13/227 ,  C12N9/88 ,  C12P13/04 ,  C12Y402/0102

Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.

公开(公告)号：US11866398B2

公开(公告)日：2024-01-09

申请号：US17055970

申请日：2019-05-14

Applicant: California Institute of Technology

Inventor： Jiaming Li ,  Xu Chen ,  Tonia S. Ahmed ,  Brian M. Stoltz ,  Robert H. Grubbs

IPC: C07C405/00 ,  B01J23/46

CPC classification number: C07C405/0016 ,  B01J23/462 ,  C07C2601/10

Abstract: This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

公开(公告)号：US20230404520A1

公开(公告)日：2023-12-21

申请号：US18336834

申请日：2023-06-16

Applicant: California Institute of Technology

Inventor： Yang Zhang ,  Joshua Olick-Gibson ,  Lihong Wang

IPC: A61B8/06 ,  A61B8/08

CPC classification number: A61B8/065 ,  A61B8/5269

Abstract: Photoacoustic computed tomography of blood flow methods and systems that reconstruct photoacoustic images, use a spatiotemporal filter to extract at least one blood component from the images, and estimate blood flow measurements from the at least one blood component.

公开(公告)号：US11843260B2

公开(公告)日：2023-12-12

申请号：US17498656

申请日：2021-10-11

Applicant: California Institute of Technology

Inventor： Seyed Ali Hajimiri ,  Florian Bohn ,  Behrooz Abiri

IPC: H02J50/20 ,  H02J50/40 ,  H02J50/80 ,  H02J50/60 ,  H02J50/90 ,  H02J50/23 ,  H01Q21/22

CPC classification number: H02J50/20 ,  H01Q21/225 ,  H02J50/23 ,  H02J50/40 ,  H02J50/60 ,  H02J50/80 ,  H02J50/90

Abstract: An RF signal generator wirelessly transferring power to a wireless device includes, in part, a multitude of generating elements generating a multitude of RF signals transmitted by a multitude of antennas, a wireless signal receiver, and a control unit controlling the phases and/or amplitudes of the RF signals in accordance with a signal received by the receiver. The signal received by the receiver includes, in part, information representative of the amount of RF power the first wireless device receives. The RF signal generator further includes, in part, a detector detecting an RF signal caused by scattering or reflection of the RF signal transmitted by the antennas. The control unit further controls the phase and/or amplitude of the RF signals in accordance with the signal detected by the detector.

公开(公告)号：US20230389805A1

公开(公告)日：2023-12-07

申请号：US18452227

申请日：2023-08-18

Applicant: California Institute of Technology

Inventor： Morteza Gharib ,  Niema M. Pahlevan

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/021 ,  A61B5/022 ,  A61B5/0285 ,  A61B7/00 ,  A61B5/318

CPC classification number: A61B5/02028 ,  A61B5/0006 ,  A61B5/021 ,  A61B5/02233 ,  A61B5/0285 ,  A61B7/00 ,  A61B5/318

Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.

公开(公告)号：US11835733B2

公开(公告)日：2023-12-05

申请号：US17023070

申请日：2020-09-16

Applicant: California Institute of Technology

Inventor： Haowen Ruan ,  Changhuei Yang ,  Jian Xu

IPC: H04B10/00 ,  G02B27/48 ,  G02B26/08 ,  H04B10/61 ,  H04B10/50 ,  G02B26/10

CPC classification number: G02B27/48 ,  G02B26/0833 ,  G02B26/105 ,  H04B10/504 ,  H04B10/61

Abstract: Optical wavefront shaping has been the standard technique to control light through scattering media. Implicit in this dominance is the assumption that knowledge of the optical phase is a necessity for optical control through scattering media. In this paper, we challenge this assumption by reporting on an intensity-only approach for light control through (or reflected from) a disordered scattering medium—optical-channel-based intensity streaming (OCIS). Instead of actively tuning the interference between the optical paths via wavefront shaping, OCIS can control light and transmit information through or from scattering media with linear intensity operation, which not only simplifies and speeds up the system but also enables new applications. We experimentally created focus patterns through scattering media in a sub-millisecond timescale with a phase-manipulation-free setup. We also demonstrate that, unlike wavefront shaping, OCIS can readily generate distinct energy null points through scattering media. Finally, we demonstrate that OCIS enables a scattering medium mediated secure optical communication application.