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公开(公告)号：US12295831B2
公开(公告)日：2025-05-13
申请号：US18508702
申请日：2023-11-14
Inventor： Yu-Chong Tai , Mark S. Humayun
IPC: A61F2/16
Abstract: An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
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公开(公告)号：US11730358B2
公开(公告)日：2023-08-22
申请号：US16786377
申请日：2020-02-10
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Mark S. Humayun
CPC classification number: A61B3/101 , A61B5/6821 , A61B5/6867 , A61B10/0045 , G01F22/00 , G01G19/00 , G01N1/10 , G01N30/02 , G01N33/4875 , A61B2010/0067 , G01N2030/027
Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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公开(公告)号：US11523939B2
公开(公告)日：2022-12-13
申请号：US16418899
申请日：2019-05-21
Inventor： Yu-Chong Tai , Aubrey M. Shapero , Nicholas E. Scianmarello , Mark S. Humayun
Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US20220348856A1
公开(公告)日：2022-11-03
申请号：US17865263
申请日：2022-07-14
Applicant: California Institute of Technology , City of Hope
Inventor： Yu-Chong Tai , Yang Liu , Colin A. Cook , Yuman Fong , Nanhai G. Chen
Abstract: Manufacturing techniques for fabricating a polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.
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公开(公告)号：US20220339464A1
公开(公告)日：2022-10-27
申请号：US17863344
申请日：2022-07-12
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Colin A. Cook
Abstract: Embodiments of the present disclosure are directed to a wearable phototherapy eye device. In an example, phototherapy can be controlled by varying an emission property of light emitted from the wearable phototherapy eye device to a user eye. In particular, the wearable phototherapy eye device includes a light source oriented to emit the light towards the user eye. The wearable phototherapy eye device also includes controls, such as electrical, mechanical, and/or electro-mechanical controls, to vary the emission property of the light based on an emission target associated with a sleep phase.
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Patent Agency Ranking
公开(公告)号：US11475987B2
公开(公告)日：2022-10-18
申请号：US16568059
申请日：2019-09-11
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Tzu-Chieh Chou , Shane S. Shahrestani
Abstract: Techniques are described for a non-invasive detection of a health condition of an organ. In an example, the electrical conductivity of the organ reflects the organ's health of. An inductive damping sensor can be used to detect the organ's electrical conductivity and, thus, its health. The inductive damping sensor can be placed in proximity of the organ such as the organ is within the magnetic field generated based on a coil of the inductive damping sensor. The conductivity of the organ impacts the inductance and the resistance of the coil. Hence, the inductance and/or resistance of the coil can be measured, where the measurements can be associated with the health of the organ.
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公开(公告)号：US11253352B2
公开(公告)日：2022-02-22
申请号：US16665623
申请日：2019-10-28
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Colin A. Cook
Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.
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8.发明授权公开(公告)号：US11154226B2
公开(公告)日：2021-10-26
申请号：US15179744
申请日：2016-06-10
Inventor： Yu-Chong Tai , Hyuck Choo , Ramiro Magalhaes Ribeiro , Mark S. Humayun
IPC: A61B5/00 , A61B5/145 , A61B5/1459 , G02B6/10 , G02B6/122 , G01J3/44 , G01N21/65 , G02B6/34 , G01N21/64 , G02B6/12
Abstract: A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.
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公开(公告)号：US20210147779A1
公开(公告)日：2021-05-20
申请号：US17098259
申请日：2020-11-13
Applicant: City of Hope , California Institute of Technology
Inventor： Colin Andrew Cook , Yuman Fong , Yu-Chong Tai , Saswati Chatterjee
Abstract: A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.
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公开(公告)号：US20200082926A1
公开(公告)日：2020-03-12
申请号：US16568059
申请日：2019-09-11
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Tzu-Chieh Chou , Shane S. Shahrestani
Abstract: Techniques are described for a non-invasive detection of a health condition of an organ. In an example, the electrical conductivity of the organ reflects the organ's health of. An inductive damping sensor can be used to detect the organ's electrical conductivity and, thus, its health. The inductive damping sensor can be placed in proximity of the organ such as the organ is within the magnetic field generated based on a coil of the inductive damping sensor. The conductivity of the organ impacts the inductance and the resistance of the coil. Hence, the inductance and/or resistance of the coil can be measured, where the measurements can be associated with the health of the organ.
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