公开(公告)号：USD1074358S1

公开(公告)日：2025-05-13

申请号：US29871647

申请日：2023-02-24

Applicant: EMD Millipore Corporation

Designer： Michael Miller ,  Kurt E. Greenizen ,  Ryan Amara ,  Christopher A. Scott ,  Paul Sydlowski ,  Kelly Wolfe

公开(公告)号：US12291738B2

公开(公告)日：2025-05-06

申请号：US17369771

申请日：2021-07-07

Applicant: The University of Chicago ,  EMD Millipore Corporation

Inventor： David A. Schwartz ,  Jimmy Williams ,  Xinfang Zhao ,  Chunfang Zhao ,  William B. Busa ,  Stephen J. Kron ,  Amy Catherine Flor

IPC: C12Q1/6804 ,  C07H21/00 ,  C12Q1/6834

Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

公开(公告)号：US12281297B2

公开(公告)日：2025-04-22

申请号：US17086249

申请日：2020-10-30

Applicant: EMD Millipore Corporation

Inventor： Roderick J. Ray ,  Adam S. Carroll ,  Brandon J. Downey ,  Lisa J. Graham

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12Q3/00 ,  G01N33/48

Abstract: The present disclosure is directed to systems and methods for sampling and/or controlling the productivity of a bioreactor. The system and methods can include a vessel capable of providing an environment suitable for containing whole broth that can produce the bioproduct, wherein the whole broth contains media and at least one undissolved species, an automated sampling system, a first analytical instrument, and a control system.

公开(公告)号：US12194454B2

公开(公告)日：2025-01-14

申请号：US17609008

申请日：2020-08-06

Applicant: EMD MILLIPORE CORPORATION

Inventor： Martin Morrissey ,  Conor King ,  Philip Borozenets

IPC: B01L1/04 ,  B25J21/00 ,  B25J21/02

Abstract: An apparatus for use with an isolator, including a crown for releasably joining with a beta port of the isolator, wherein the crown includes at least one anchoring support; a spring hook on at least one end of the at least one anchoring support; a needle block including at least one through hole for having a needle positioned therein, wherein the at least one needle is joined with tubing; a yoke; and a biasing element releasably joined with the yoke and the at least one anchoring support; wherein the needle block is releasably joined to the crown.

公开(公告)号：US20240367122A1

公开(公告)日：2024-11-07

申请号：US18687944

申请日：2022-11-16

Applicant: EMD Millipore Corporation

Inventor： Sualyneth Galarza ,  Anne Hansen ,  Amy Mei ,  Amy Wood ,  James J. Vigna ,  Marisa Maher

IPC: B01F27/2122 ,  B01F27/17 ,  B01F33/453

Abstract: A hollow shaft impeller (100) having a hollow impeller housing (120), a magnet (108), an impeller cap (102), an impeller retainer (106), and a plurality of impeller blades (134). The impeller housing has a hub (130) that defines an interior volume (128) and an impeller bore that provides access to the interior volume. The magnet may be sized to be disposed within the interior volume. The impeller cap may be removably coupled to the hollow impeller housing proximate to the impeller bore. The impeller retainer may be removably coupled to the magnet and sized to be disposed within the interior volume. The plurality of impeller blades may project from the hub. Optionally, fins (140) may be disposed on each of the plurality of impeller blades.

公开(公告)号：US12076666B2

公开(公告)日：2024-09-03

申请号：US17312109

申请日：2020-03-26

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  John Paul Amara ,  Kara M. Pizzelli ,  Shannon Ryan

IPC: B01D24/10 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  G01N1/34 ,  G01N1/40

CPC classification number: B01D24/10 ,  B01D39/1623 ,  B01D39/18 ,  B01D39/2068 ,  G01N1/34 ,  G01N1/4077 ,  B01D2201/182 ,  G01N2001/4088

Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.

公开(公告)号：US12053729B2

公开(公告)日：2024-08-06

申请号：US18334925

申请日：2023-06-14

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  Dana Kinzlmaier ,  Kara Pizzelli ,  Elizabeth Goodrich

IPC: B01D37/02 ,  B01D39/18 ,  B01D71/10 ,  C12M1/12 ,  D21C9/00

CPC classification number: B01D39/18 ,  B01D37/025 ,  B01D71/10 ,  C12M37/02 ,  D21C9/004 ,  D21C9/005

Abstract: Treatment methods for reduction of (1→3)-β-D-glucan leachables from cellulose-containing filter materials are described.

公开(公告)号：US20240228943A1

公开(公告)日：2024-07-11

申请号：US18441850

申请日：2024-02-14

Applicant: EMD Millipore Corporation

Inventor： David Dixon Newbold ,  Clinton Boyd Pepper ,  David Andrew Hansen

IPC: C12M1/00 ,  B01D27/08 ,  B01D35/26 ,  B01D61/18 ,  B01D63/00 ,  B01D63/02 ,  B01L1/00 ,  B01L3/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00 ,  H04W74/0808 ,  H04W84/12

CPC classification number: C12M47/02 ,  B01D61/18 ,  B01D63/02 ,  B01L3/502 ,  C12M23/28 ,  C12M23/42 ,  C12M29/04 ,  C12M29/16 ,  C12M33/04 ,  C12M33/14 ,  H04W74/0808 ,  B01D27/08 ,  B01D35/26 ,  B01D63/005 ,  B01D63/028 ,  B01D2313/203 ,  B01D2313/24 ,  B01D2315/10 ,  B01L1/52 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/0478 ,  C12M1/126 ,  C12M37/02 ,  H04W84/12

Abstract: A filtration system, having a filtration unit comprising a housing with a sample inlet, a sample outlet, one or more valves, a first actuator, and a second actuator and a third actuator; and a cassette adapted to fit the filtration unit, the cassette having a filter; a first reservoir in fluid communication with the filter, the first reservoir being arranged to couple to the first actuator for imparting flow to a cell-containing solution in a first direction through the filter; a second reservoir in fluid communication with the filter, the second reservoir being arranged to couple to the second actuator for imparting flow to a cell-containing solution in a second direction through said filter, wherein the second direction opposes the first direction; and a third reservoir.

公开(公告)号：US20240226811A1

公开(公告)日：2024-07-11

申请号：US18437727

申请日：2024-02-09

Applicant: EMD Millipore Corporation

Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

CPC classification number: B01D63/087 ,  B01D61/18 ,  B01D61/20 ,  B01D2201/204

Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s).

公开(公告)号：USD1033591S1

公开(公告)日：2024-07-02

申请号：US29799410

申请日：2021-07-14

Applicant: EMD Millipore Corporation

Designer： James Ormond ,  Gregory Straeffer ,  Bailey Vaillancourt ,  Joseph Michael Almasian

Abstract: FIG. 1 is a first perspective view of a first embodiment of the filter assembly stand of the present invention.
FIG. 2 is a second perspective view of the first embodiment of the filter assembly stand of the present invention.
FIG. 3 is a front view of the first embodiment of the filter assembly stand of the present invention.
FIG. 4 is a rear view of the first embodiment of the filter assembly stand of the present invention.
FIG. 5 is a left-side view of the first embodiment of the filter assembly stand of the present invention.
FIG. 6 is a right-side view of the first embodiment of the filter assembly stand of the present invention.
FIG. 7 is a top view of the first embodiment of the filter assembly stand of the present invention.
FIG. 8 is a bottom view of the first embodiment of the filter assembly stand of the present invention; and,
FIG. 9 is a view of the first embodiment of the filter assembly stand of the present invention illustrating environmental context holding two filter unit assemblies together.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting her orientation of the bracket.
The broken lines in the Figures are for illustrative purposes only and form no part of the claimed design.