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    UNIVERSAL MAMMALIAN INFLUENZA VACCINE
    91.
    发明申请
    UNIVERSAL MAMMALIAN INFLUENZA VACCINE 审中-公开

    公开(公告)号：US20190321459A1

    公开(公告)日：2019-10-24

    申请号：US16400817

    申请日：2019-05-01

    Applicant: Iowa State University Research Foundation, Inc.

    Inventor： David Verhoeven ,  Jessie Dorothy Trujillo ,  Brett Sponseller

    IPC: A61K39/145 ,  A61P31/16 ,  C12N7/00 ,  C07K14/005

    Abstract: The present invention provides vaccine or immunogenic compositions comprising novel antigens derived from the equine strain of influenza H3N8. These proteins and specific immunogenic domains are effective as primary universal influenza antigens. The disclosed vaccines or immunogenic compositions are highly effective in inducing HA specific antibodies reactive to different influenza viruses, mucosal and systemic immune responses, and cross-protection regardless of influenza virus subtypes. In some embodiments, the vaccine is cross-protective against two or more (e.g., 2, 3, 4, 5, or 6) subtypes of influenza with or without the use of an adjuvant.

    Tackifier compounds and methods of using the same
    99.
    发明授权
    Tackifier compounds and methods of using the same 有权

    公开(公告)号：US10280241B2

    公开(公告)日：2019-05-07

    申请号：US15881117

    申请日：2018-01-26

    Applicant: Iowa State University Research Foundation, Inc.

    Inventor： Jason Shih-Hao Chen ,  Michael Richard Kessler ,  Michael Dennis Zenner

    IPC: C08F122/20 ,  C07D493/04 ,  C09J4/00 ,  C08L75/08 ,  C09J135/02 ,  C08G18/32 ,  C08G18/77 ,  B60L11/18 ,  H04B3/54

    Abstract: The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C5-C10)cycloalkyl and (C2-C10)heterocyclyl. Fused ring A is substituted with (R1)1-8 and fused ring B is substituted with —(OC(O)R′C(O)R2)1-8. At each occurrence R′ is independently chosen from (C2-C10)alkanylene, (C2-C10)alkenylene, (C2-C10)alkynylene, C5-C20(arylene), and (C1-C20)heteroarylene, wherein R′ is unsubstituted or substituted. At each occurrence R1 is independently selected from —OH, —OR3, and —OC(O)R′C(O)R2. At each occurrence R2 is independently chosen from —OH, —OR3, —NH2, —NHR3, and —NR32. At each occurrence R3 is independently chosen from (C1-C10)alkanyl, (C2-C10)alkenyl, (C2-C10)alkynyl, C5-C20(aryl), and (C1-C20)heteroaryl, wherein R3 is unsubstituted or substituted.

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