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    Systems and Methods using Nucleic Acid Photoacoustic Nanosensors for Cytokine Detection
    91.
    发明申请
    Systems and Methods using Nucleic Acid Photoacoustic Nanosensors for Cytokine Detection 有权

    公开(公告)号：US20220183562A1

    公开(公告)日：2022-06-16

    申请号：US17549345

    申请日：2021-12-13

    Applicant: Northeastern University

    Inventor： Heather A. Clark ,  Kevin Bardon ,  Nicole Langlois

    IPC: A61B5/00

    Abstract: A DNA-based nanosensor system performs photoacoustic detection of cytokines. Cytokine receptors and a photoacoustic reporter dye are used in the nanosensor for cytokine detection, which can be reversible, and can be performed continuously, in vivo, in real time. Upon receptor binding to the cytokine, the DNA structure of the nanosensor closes to induce controlled dye stacking for photoacoustic application/interrogation, resulting in an increase in photoacoustic signal in the presence of the detected cytokine. The open or closed state of the sensor can be determined through differential signals as detected with photoacoustic imaging. A system using the nanosensor performs simultaneous multiplexed cytokine imaging, in the form of an inline and removable system paired with a clinical photoacoustic instrument. Cytokines can be detected in animal research use and in human point-of-care use.

    Lightweight Decompositional Convolution Neural Network
    93.
    发明申请
    Lightweight Decompositional Convolution Neural Network 有权

    公开(公告)号：US20220156554A1

    公开(公告)日：2022-05-19

    申请号：US17594061

    申请日：2020-06-03

    Applicant: Northeastern University

    Inventor： Yun Fu ,  Bin Sun

    IPC: G06N3/04 ,  G06N3/08

    Abstract: A neural network (NN) and corresponding method employ an NN element (NNE) that includes a depthwise convolutional layer (DCL). The DCL outputs respective features by performing spatial convolution of respective input features having an original number of dimensions. The NNE includes a compression-expansion (CE) module that includes a first convolutional layer (CL) and second CL. The first CL outputs respective features as a function of respective input features. The respective features output from the first CL have a reduced number of dimensions relative to the original number of dimensions. The second CL outputs respective features, having the original number of dimensions, as a function of the respective features output from the first CL. The NNE further includes an add operator that outputs respective features as a function of the respective features output from the second CL and DCL. The NNE enables the NN to have a reduced size and to process data with competitive performance relative to conventional lightweight deep neural networks.

    Hanging Cell Culture Millifluidic Device
    94.
    发明申请
    Hanging Cell Culture Millifluidic Device 有权

    公开(公告)号：US20220154120A1

    公开(公告)日：2022-05-19

    申请号：US17454768

    申请日：2021-11-12

    Applicant: Northeastern University

    Inventor： Eno Essien Ebong ,  Ian Harding ,  Ira M. Herman ,  Abigail N. Koppes ,  Alex Caraballo ,  Nicholas O'Hare ,  Mark Vigliotti

    IPC: C12M3/00 ,  C12M3/06 ,  C12M1/00 ,  G01N33/50

    Abstract: Devices and systems for cell culture analysis are provided. A device for cell culture analysis includes a first component comprising a receptacle configured to receive a cell culture insert having an apical surface and a basal surface and a second component. The device further includes an inlet port disposed at at least one of the first and second components and an outlet port disposed at at least one of the first and second components. The first component and second component are releasably couplable and configured to define a flow path from the inlet port to the outlet port when in a coupled state. The flow path is at least partially defined by a surface of the second component, and the first component is configured to expose the basal surface of the cell culture insert to the flow path.

    Visualized time sequence pattern matching method for data visualization analysis based on Hough transformation
    96.
    发明授权
    Visualized time sequence pattern matching method for data visualization analysis based on Hough transformation 有权

    公开(公告)号：US11328502B2

    公开(公告)日：2022-05-10

    申请号：US16960483

    申请日：2019-04-12

    Applicant: Northeastern University

    Inventor： Jinliang Ding ,  Quan Xu ,  Meirong Xu ,  Xiaoran Yu

    IPC: G06V10/75 ,  G06K9/62

    Abstract: The invention provides a visualized time sequence pattern matching method based on Hough transformation, and relates to the technical field of data visualization analysis. The method comprises the steps of: firstly, judging whether historical data to be matched is one-dimensional time sequence data or multi-dimensional time sequence data, and if the historical data to be matched is the multi-dimensional time sequence data, performing normalization processing; performing time sequence selection: selecting a time sequence to be matched from the historical data in a time window pattern, and eliminating the selected time sequence from the historical data; converting a time sequence image in original coordinates to Hough space through the Hough transformation, and judging the similarity matching situation of the time sequence through a voting mechanism; and finally, screening the finally-matched results according to the voting results.

    Manganese Ferrite Nanoparticles for Use as MRI Contrast Agents and Magnetohypothermia Agents
    98.
    发明申请
    Manganese Ferrite Nanoparticles for Use as MRI Contrast Agents and Magnetohypothermia Agents 有权

    公开(公告)号：US20220118114A1

    公开(公告)日：2022-04-21

    申请号：US17421607

    申请日：2020-01-09

    Applicant: Northeastern University

    Inventor： Parisa ANDALIB ,  Vincent G. HARRIS

    IPC: A61K49/18 ,  A61K41/00 ,  A61K9/16 ,  A61K47/69 ,  A61K47/54

    Abstract: The present disclosure is directed to methods of Quantum Spin Engineering of spinel superparamagnetic ferrite nanoparticles (SMFNs) for MRI contrast agents and for magnetohyperthermia agents. Using the methods herein, the magnetic properties of the SMFNs can be controlled by changing the amount of 3d-transition element cations having unpaired electrons in the 3d orbital that occupy the octahedral sites of the spinel crystal form, to form mixed spinels, while anions in the spinels can be utilized to magnetically couple the cations utilizing intra-crystalline angles determined by ion sizes and crystal structure, and further tuning of other critical parameters is provided. The mixed spinels disclosed herein provide enhanced MRI contrast agents and improved magnetohyperthermia agents with lower toxicity and safety concerns, while the production methods disclosed herein have lower cost.

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