公开(公告)号：US06678443B2

公开(公告)日：2004-01-13

申请号：US09772609

申请日：2001-01-30

Applicant: Johann Engelhardt

Inventor： Johann Engelhardt

IPC: G02B600

CPC classification number: G02B6/3616 ,  G02B7/003

Abstract: The present invention concerns an apparatus for slewing a light beam, having a base element and a support element carrying a light source or an optical component, wherein connecting elements which allow movement of the support element relative to the base element extend between the base element and the support element. The apparatus according to the present invention eliminates or at least reduces the disadvantages of additionally used optical components. The apparatus is characterized in that the connecting elements are spaced apart differently at their ends facing toward the base element and their ends facing toward the support element.

Abstract translation: 本发明涉及一种用于回转光束的装置，具有基座元件和承载光源或光学元件的支撑元件，其中允许支撑元件相对于基座元件移动的连接元件在基座元件和 支撑元件。 根据本发明的装置消除或至少减少了额外使用的光学部件的缺点。 该装置的特征在于，连接元件在其朝向基部元件的端部处不同地间隔开，并且其端部朝向支撑元件。

公开(公告)号：US06678089B1

公开(公告)日：2004-01-13

申请号：US09549026

申请日：2000-04-13

Applicant: Johann Engelhardt ,  Joachim Bradl

Inventor： Johann Engelhardt ,  Joachim Bradl

IPC: G02B2100

CPC classification number: G02B21/0024

Abstract: A microscope (1), preferably a confocal laser scanning microscope, having at least one light source, a detector, and two objectives (2), one of the objectives (2) being arranged on each of the two sides of the specimen plane (3) and the objectives (2) being directed toward one another and having a common focus; and at least one beam splitter (5) for distributing the illuminating light (6) to the objectives (2), and a beam recombiner (5) for combining the detected light (7) coming from the objectives (2), being provided in the illumination/detection beam path (4), is characterized, for selectable, subsequent implementation of ultrahigh-resolution microscope techniques, in that the objectives (2) and the beam splitter/beam recombiner (5) are grouped into a modular assembly (8); and the assembly (8) has an interface (9) for connection to the illumination/detection beam path (4) of the microscope (1).

Abstract translation: 具有至少一个光源，检测器和两个物镜（2）的显微镜（1），优选共聚焦激光扫描显微镜，物镜（2）中的一个被布置在样品平面的两侧 3）和目标（2）相互指向并共同关注; 以及用于将照明光（6）分配到物镜（2）的至少一个分束器（5）和用于组合来自物镜（2）的检测光（7）的光束重组器（5），其设置在 其特征在于，为了可选择地实现超高分辨率显微镜技术，其目的（2）和分束器/光束重组器（5）被分组成模块化组件（8） ）; 并且组件（8）具有用于连接到显微镜（1）的照明/检测光束路径（4）的接口（9）。

公开(公告)号：US06664537B2

公开(公告)日：2003-12-16

申请号：US09921313

申请日：2001-08-03

Applicant: Johann Engelhardt ,  Juergen Hoffmann

Inventor： Johann Engelhardt ,  Juergen Hoffmann

IPC: H01J314

CPC classification number: G02B21/0048 ,  G02B21/0072 ,  G02B21/0076

Abstract: A scanning microscope, in particular a confocal scanning microscope, with a light source (1), preferably a laser, for generating an illumination light beam (14) for a sample (11) and a scanning device for deflecting the illumination light beam (14) is, with a view to fast and reliable image-data acquisition and a compact structure, configured and refined in such a way that the scanning device has at least one micromirror (16). An optical arrangement with a light source (1), preferably a laser, for generating a light beam and at least one micromirror (16) for deflecting the light beam is furthermore provided, in which an adaptive lens (22) is provided for correcting for mirror defects or deformation of the mirror surface. Lastly, a method for imaging in scanning microscopy, in particular in confocal scanning microscopy, with a light source (1), preferably a laser, for generating an illumination light beam (14) for a sample (11) and a scanning device for deflecting the illumination light beam (14) is provided, in which at least one micromirror (16) is used in the scope of the scanning device.

公开(公告)号：US06603553B1

公开(公告)日：2003-08-05

申请号：US09681109

申请日：2001-01-10

Applicant: Johann Engelhardt

Inventor： Johann Engelhardt

IPC: G01N2164

CPC classification number: G01N21/6454

Abstract: An arrangement is proposed for detecting fluorescent light from a plurality of specimen points (2), in particular from microgene spots or microbiospots, the specimen points (2) being arranged on a slide (1). This arrangement comprises at least one light source for simultaneously illuminating the specimen points (2) with excitation light, and detection means, comprising detection elements (3), for simultaneously detecting the fluorescent light from the individual specimen points (2). According to the invention, the spacing d between the specimen points (2) and the respectively assigned detection elements (3) is selected to be as small as possible.

Abstract translation: 提出了用于从多个样本点（2），特别是从微基因点或微生物群中检测荧光的装置，将样本点（2）布置在幻灯片（1）上。 这种布置包括用于用激发光同时照射样本点（2）的至少一个光源，以及包括检测元件（3）的检测装置，用于同时检测来自各个样本点（2）的荧光。 根据本发明，样本点（2）和分配的检测元件（3）之间的间隔d被选择为尽可能小。

公开(公告)号：US06576901B1

公开(公告)日：2003-06-10

申请号：US09713071

申请日：2000-11-15

Applicant: Johann Engelhardt

Inventor： Johann Engelhardt

IPC: G02B2126

CPC classification number: G02B21/0036

Abstract: The invention concerns an arrangement for scanning a specimen receiving device (1) for data recording with a laser scanning microscope, preferably with a confocal laser scanning microscope (2), with which imaging of large specimen fields with sufficient speed is possible by scanning of the specimen receiving device (1), which is characterized in that the specimen receiving device (1) is alternatingly rotatable about a first axis (4) by a rotation device (3).

Abstract translation: 本发明涉及用激光扫描显微镜，优选用共聚焦激光扫描显微镜（2）扫描用于数据记录的样本接收装置（1）的装置，通过扫描具有足够速度的大样本场的成像， 样本接收装置（1），其特征在于，所述检体接收装置（1）通过旋转装置（3）围绕第一轴线（4）交替旋转。

公开(公告)号：US06567212B1

公开(公告)日：2003-05-20

申请号：US09639592

申请日：2000-08-16

Applicant: Johann Engelhardt ,  Rafael Storz

Inventor： Johann Engelhardt ,  Rafael Storz

IPC: G02B2100

CPC classification number: G02B21/24

Abstract: A Vibration damping device for a microscope comprises a housing. In the housing a foam rubber defining a cavity is formed which encloses a weight. The foam rubber has a plurality of interconnected pores. The housing is of the vibration damping device has in one embodiment a rectangular shape.

Abstract translation: 用于显微镜的振动阻尼装置包括壳体。 在壳体中形成限定空腔的泡沫橡胶，其包围重物。 泡沫橡胶具有多个互连孔。 在一个实施例中，壳体是减振装置的矩形形状。

公开(公告)号：US06483103B2

公开(公告)日：2002-11-19

申请号：US09783220

申请日：2001-02-15

Applicant: Johann Engelhardt ,  William C. Hay ,  Juergen Hoffmann

Inventor： Johann Engelhardt ,  William C. Hay ,  Juergen Hoffmann

IPC: G01J328

CPC classification number: G02B21/0064 ,  G01J3/32

Abstract: An apparatus for selecting and detecting at least one spectral region of a spectrally spread light beam, preferably in the beam path of a confocal scanning microscope, the spread light beam being focussable in a focal line, is characterized, for non-overlapping detection of the spectrally spread light beam of the selected spectral regions in the context of an increased number of detectors and an error-tolerant arrangement, in that there is arranged in the spread light beam an optical component which reflects and/or refracts the light beam to a detector and whose optically effective region becomes smaller or larger along the surface, so that by orientation of the component with respect to the focal line and the resulting superposition of the focal line and surface, the spectral region arriving at the detector is definable.

Abstract translation: 一种用于选择和检测光谱扩展光束的至少一个光谱区域的装置，优选地在共聚焦扫描显微镜的光束路径中，扩散光束可聚焦在焦线中，其特征在于，对于不重叠的 在增加数量的检测器和容错布置的上下文中，所选择的光谱区域的光谱扩展光束，其中在扩展光束中布置了将光束反射和/或折射到检测器的光学部件 并且其光学有效区域沿着表面变得更小或更大，使得通过部件相对于焦线的取向以及所得焦点线和表面的叠加，到达检测器的光谱区域是可定义的。

公开(公告)号：US06222961B1

公开(公告)日：2001-04-24

申请号：US09147131

申请日：1998-10-15

Applicant: Johann Engelhardt ,  Heinrich Ulrich

Inventor： Johann Engelhardt ,  Heinrich Ulrich

IPC: G02B2100

CPC classification number: G02B27/145 ,  G02B21/002

Abstract: A point light source is disclosed for a laser scanning microscope (7). At least two lasers (1 and/or 2 and/or 3; 4) with different wavelengths may be coupled in the microscope (7). To combine the advantages of a multiline laser with those of the use of several independent one-line lasers, the point light source is characterised by at least two laser light sources the beam of which are fed into a beam combiner (5), and by an optical fibre (6) which leads directly or indirectly from the beam combiner (5) to the microscope (7).

Abstract translation: 公开了一种用于激光扫描显微镜（7）的点光源。 具有不同波长的至少两个激光器（1和/或2和/或3; 4）可以在显微镜（7）中耦合。 为了将多行激光器的优点与使用几个独立的单线激光器的优点相结合，点光源的特征在于至少两个激光源，其光束被馈送到光束组合器（5）中，并且由 从光束组合器（5）直接或间接引导到显微镜（7）的光纤（6）。

公开(公告)号：US6150666A

公开(公告)日：2000-11-21

申请号：US319245

申请日：1999-06-07

Applicant: Johann Engelhardt ,  Thomas Zapf ,  Heinrich Ulrich

Inventor： Johann Engelhardt ,  Thomas Zapf ,  Heinrich Ulrich

IPC: A61C1/08 ,  A61C19/04 ,  A61C19/05 ,  G01B11/24 ,  G02B21/00 ,  G02B21/36 ,  G02B27/14 ,  G01N21/86

CPC classification number: G02B27/143 ,  A61C19/04 ,  G01B11/24 ,  A61C1/088 ,  A61C19/05 ,  G01B2210/50

Abstract: A system and method for simultaneous representation of a surface profile of any given object, specially to measure the surface profile of teeth, comprises a light source to illuminate the object, an optical element to focus the light signals returning from the surface of the object, a detector to pick up the light signals, and a processor that digitizes and further processes the detected signals. The method enables quick, reproducible scanning of the surface profile by using as few devices as possible while ensuring at the same time a viable constructive size. The method includes placing a beam output coupler in the beam detection path downstream from the optical element to simultaneously couple our the light returning from the various image planes, the coupled-out light being guided to the detector.

Abstract translation: PCT No.PCT / DE97 / 02851 Sec。 371日期1999年6月7日 102（e）日期1999年6月7日PCT 1997年12月5日PCT公布。 公开号WO98 / 25171 日期1998年6月11日用于同时表示任何给定对象的表面轮廓的系统和方法，特别是用于测量牙齿的表面轮廓的系统和方法包括照亮物体的光源，用于聚焦从 物体的表面，用于拾取光信号的检测器，以及对检测到的信号进行数字化和进一步处理的处理器。 该方法通过使用尽可能少的装置来实现对表面轮廓的快速，可重复的扫描，同时确保可行的建设性尺寸。 该方法包括将光束输出耦合器放置在光学元件下游的光束检测路径中，以同时耦合我们从各种图像平面返回的光，将被耦合的光引导到检测器。

公开(公告)号：US6137627A

公开(公告)日：2000-10-24

申请号：US242120

申请日：1999-05-24

Applicant: Johann Engelhardt ,  Klaus Kierschke

Inventor： Johann Engelhardt ,  Klaus Kierschke

IPC: G02B21/26

CPC classification number: G02B21/26

Abstract: A fine-focusing stage for microscopes, with an object carrier (1) , a holder (2) for the object carrier (1) and a positioning mechanism (3) adjusting the support in its horizontal position. In order to achieve parallel vertical displacement of the object carrier (1) using simple methods of construction the invention is so designed that the holder (2) comprises a mounting portion (4) preferably for mounting on an object stage or on the microscope and a connecting portion (5) with the object carrier, and articulated parallel arms (8,9) through bending elements (6,7) extend between the mounting portion (4) and the connecting portion (5).

Abstract translation: PCT No.PCT / DE97 / 01630 Sec。 371日期1999年5月24日 102（e）日期1999年5月24日PCT提交1997年8月1日PCT公布。 出版物WO98 / 08126 日期1998年2月26日用于显微镜的精细聚焦台，具有物体载体（1），用于物体载体（1）的保持器（2）和在其水平位置调节支撑件的定位机构（3）。 为了使用简单的构造方法实现物体载体（1）的平行垂直位移，本发明被设计成使得保持器（2）包括优选用于安装在物体台上或显微镜上的安装部分（4）和 连接部分（5）与对象载体相连接，并且通过弯曲元件（6,7）的铰接平行臂（8,9）在安装部分（4）和连接部分（5）之间延伸。