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    SYSTEM AND METHOD FOR AUTOMATED BIOPARTICLE RECOGNITION
    91.
    发明申请
    SYSTEM AND METHOD FOR AUTOMATED BIOPARTICLE RECOGNITION 审中-公开
    自动生物识别系统与方法

    公开(公告)号：US20140371102A1

    公开(公告)日：2014-12-18

    申请号：US14474267

    申请日：2014-09-01

    Applicant: Mark A. Hayes ,  Thomas J. Taylor

    Inventor： Mark A. Hayes ,  Thomas J. Taylor ,  Karl Booksh ,  Neal Woodbury ,  Pierre Herckes

    IPC: G01N27/447

    CPC classification number: G01N27/44756 ,  B03C5/005 ,  B03C2201/26 ,  G01N21/553 ,  G01N2015/0088

    Abstract: Disclosed are embodiments of methods, apparatus, systems, compositions, and articles of manufacture relating to identifying the source of bioparticles, such as bioparticles shed by an organism. In embodiments, a method may include collecting a sample of bioparticles from the environment, selecting from that sample the bioparticles most informative for identifying their source, and gathering data from those bioparticles to form bioparticle signatures; the bioparticle signatures may be processed into a multi-dimensional vector which may be compared to a multi-dimensional vector derived from a standard using a pattern recognition strategy. In embodiments, an apparatus may include a particle collection device to collect a sample, a transfer device to select bioparticles, and a detector that restricts the movement of the bioparticles; the restricted movement may be used to produce a bioparticle signature.

    Abstract translation: 公开了与识别生物颗粒源如生物体脱落的生物颗粒有关的方法，装置，系统，组合物和制品的实施方案。 在实施方案中，方法可以包括从环境中收集生物颗粒的样品，从该样品中选择生物颗粒最有用的资料来识别其来源，以及从这些生物颗粒收集数据以形成生物颗粒标记; 生物粒子标记可以被处理成多维向量，其可以使用模式识别策略与从标准衍生的多维向量进行比较。 在实施例中，装置可以包括用于收集样品的颗粒收集装置，选择生物颗粒的转移装置和限制生物颗粒运动的检测器; 受限运动可用于产生生物粒子标记。

    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS
    93.
    发明申请
    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS 审中-公开
    用于确定多种癌细胞的性质的电化学方法

    公开(公告)号：US20140339088A1

    公开(公告)日：2014-11-20

    申请号：US14449050

    申请日：2014-07-31

    Applicant: Eva M. Schmelz ,  Elizabeth S. Elvington ,  Alireza Salmanzadeh ,  Mike Sano ,  Paul C. Roberts ,  Rafael V. Davalos

    Inventor： Eva M. Schmelz ,  Elizabeth S. Elvington ,  Alireza Salmanzadeh ,  Mike Sano ,  Paul C. Roberts ,  Rafael V. Davalos

    IPC: G01N33/487 ,  G01N27/447 ,  G01N33/50

    CPC classification number: G01N33/48735 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/44704 ,  G01N33/5011 ,  G01N33/5023

    Abstract: Provided are dielectrophoresis (DEP) devices and methods that allow cell sorting to identify, isolate, and/or separate cells of interest based on electrical and physical properties of the cells. Particularly, provided are systems and methods for manipulating particles suspended in a fluid, e.g., cells, micro- or nano-particles, using their electrical signatures. Such methods can be performed using DEP, iDEP, and/or cDEP (contactless dielectrophoresis, where direct contact between the electrodes and the sample is avoided). Typically, an electric field is induced in a sample comprising the target particles and/or cells, such as cancer cells, and the spatial distribution of cells is measured to identify one or more characteristics or properties of the cancer cells. The identified characteristics of the sorted cells can be used to determine drug efficacy and/or resistance with respect to the cells.

    Abstract translation: 提供的是介电电泳（DEP）装置和方法，其允许细胞分选基于细胞的电学和物理性质鉴定，分离和/或分离感兴趣的细胞。 特别地，提供了使用其电特征来操纵悬浮在流体中的颗粒（例如，细胞，微米或纳米颗粒）的系统和方法。 可以使用DEP，iDEP和/或cDEP（非接触式介电电泳，其中避免了电极和样品之间的直接接触）来执行这些方法。 通常，在包含靶颗粒和/或细胞（例如癌细胞）的样品中诱导电场，并且测量细胞的空间分布以鉴定癌细胞的一个或多个特征或性质。 分选的细胞的鉴定特征可用于确定相对于细胞的药物功效和/或抗性。

    Magnetic Rack
    94.
    发明申请
    Magnetic Rack 审中-公开
    磁性架

    公开(公告)号：US20140305849A1

    公开(公告)日：2014-10-16

    申请号：US14244907

    申请日：2014-04-04

    Applicant: Nvigen, Inc.

    Inventor： Aihua Fu

    IPC: B03C1/32 ,  B01L9/06

    CPC classification number: B03C1/00 ,  B01L9/06 ,  B01L2200/0668 ,  B01L2400/043 ,  B03C1/288 ,  B03C2201/20 ,  B03C2201/26

    Abstract: The present application provides a magnetic rack for separating magnetic particles from a non-magnetic medium. The magnetic rack comprises a supporting housing having a top side, a bottom side, two opposite lengthwise sides, and a cavity, wherein at least one magnet is disposed in the cavity, each lengthwise side is attached with a receiving member, and the top side has at least two sockets. The magnetic rack further comprises a pair of supporting walls, wherein each supporting wall has a fixing member introduced onto or into the receiving member to tightly connect the supporting housing with the pair of supporting walls. With the coupling of the receiving member and the fixing member, the supporting wall and the supporting housing can be tightly connected together, therefore the shake of the magnetic rack or the sample vials inserted in the magnetic rack can be significantly avoided. In this way, the magnetic particles can be effectively separated from a non-magnetic medium in the sample vial.

    Abstract translation: 本申请提供了用于从非磁性介质分离磁性颗粒的磁性架。 该磁性架包括一个具有顶侧，底侧，两个相对的纵向侧面和空腔的支撑壳体，其中至少一个磁体设置在空腔中，每个纵向侧面都安装有接收构件，顶侧 至少有两个插座。 磁性架还包括一对支撑壁，其中每个支撑壁具有引导到接收构件上或接收构件中的固定构件，以将支撑壳体与一对支撑壁紧密连接。 通过接收构件和固定构件的联接，支撑壁和支撑壳体可以紧密连接在一起，因此可以显着地避免插入磁架中的磁性架或样品瓶的晃动。 以这种方式，磁性颗粒可以有效地与样品瓶中的非磁性介质分离。

    Methods, Systems and Apparatus for Size-Based Particle Separation
    100.
    发明申请
    Methods, Systems and Apparatus for Size-Based Particle Separation 有权
    用于大小粒子分离的方法，系统和装置

    公开(公告)号：US20140091012A1

    公开(公告)日：2014-04-03

    申请号：US14041712

    申请日：2013-09-30

    Applicant: Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    Inventor： Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    IPC: B03C7/02

    CPC classification number: B03C7/02 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26

    Abstract: A microfluidic device for size-based particle separation and methods for its use, where the microfluidic device comprises: (a) an inlet reservoir, where the inlet reservoir is configured for communication with an inlet electrode, (b) an insulator constriction coupled to the inlet reservoir via a microchannel, where the insulator constriction comprises an insulating material, and (c) a plurality of outlet channels each defining a first end and a second end, where the first end of each of the plurality of outlet channels is coupled to the insulator constriction, where the second end of each of the plurality of outlet channels is coupled to one of a plurality of outlet reservoirs, and where the plurality of outlet reservoirs are configured for communication with one or more outlet electrodes.

    Abstract translation: 一种用于基于尺寸的颗粒分离的微流体装置及其使用方法，其中所述微流体装置包括：（a）入口储存器，其中所述入口储存器被配置为与入口电极连通，（b）绝缘体收缩部， 入口储存器，其中所述绝缘体收缩部包括绝缘材料，以及（c）多个出口通道，每个出口通道限定第一端和第二端，其中所述多个出口通道中的每一个的第一端连接到所述入口储存器， 绝缘体收缩，其中多个出口通道中的每一个的第二端联接到多个出口储存器中的一个，并且其中多个出口储存器被配置为与一个或多个出口电极连通。

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