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公开(公告)号：US20170089929A1
公开(公告)日：2017-03-30
申请号：US15373657
申请日：2016-12-09
Applicant: University Health Network
Inventor： Avijit Chakrabartty , Rishi Rakhit , Anita Antoinette Bugyei-Twum
CPC classification number: G01N33/78 , C07K14/47 , C07K14/575 , C07K16/18 , C07K16/26 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N2800/046 , G01N2800/28 , G01N2800/325 , G01N2800/7047
Abstract: The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.
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102.发明授权公开(公告)号：US09545231B2
公开(公告)日：2017-01-17
申请号：US13842683
申请日：2013-03-15
Applicant: University Health Network
Inventor： David A. Jaffray , Sean Alexander Graham , Jeffrey Harold Siewerdsen , Steven Joe Bartolac
CPC classification number: A61B6/032 , A61B6/035 , A61B6/06 , A61B6/405 , A61B6/5282 , A61B6/542 , A61B6/545 , G21K1/04 , G21K1/043 , G21K1/046
Abstract: A method and imaging system for operating imaging computed tomography using at least one radiation source and at least one detector to generate an image of an object. The method includes: defining desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the at least one radiation source, to generate said desired image quality or characteristics. Then, the at least one radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.
Abstract translation: 一种用于使用至少一个辐射源和至少一个检测器来操作成像计算机断层摄影术以产生对象的图像的方法和成像系统。 该方法包括：定义所需的图像特征; 以及执行计算以确定要由所述至少一个辐射源施加的注量的模式，以产生所述期望的图像质量或特性。 然后，对该至少一个辐射源进行调制，以产生射束源和待成像对象之间的注量图形。 期望的图像特征可以提供至少一个：在至少一个限定的感兴趣区域中的期望图像质量; 以及所述图像质量的至少一个期望分布。
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公开(公告)号：US09534048B2
公开(公告)日：2017-01-03
申请号：US13974761
申请日：2013-08-23
Applicant: University Health Network
Inventor： Avijit Chakrabartty , Rishi Rakhit , Anita Antoinette Bugyei-Twum
CPC classification number: G01N33/78 , C07K14/47 , C07K14/575 , C07K16/18 , C07K16/26 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N2800/046 , G01N2800/28 , G01N2800/325 , G01N2800/7047
Abstract: The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.
Abstract translation: 本公开涉及特异性结合全部或部分EHAEVVFTA的抗体及其结合片段。 还提供了分离的肽，分离的核酸，免疫原，组合物，免疫测定和试剂盒以及使用所述试剂检测错误折叠的TTR的方法。
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公开(公告)号：US20160215263A1
公开(公告)日：2016-07-28
申请号：US14915992
申请日：2014-09-12
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gordon KELLER , Alec Drake WITTY , Steven James KATTMAN
Abstract: Provided are methods and products for obtaining cardiovascular lineage cells from hPSCs. The method for obtaining a cardiomyocyte lineage or an epicardial lineage cell population from human pluripotent stem cells (hPSCs) comprises one or more of the following steps: (a) contacting BMP component primed hPSCs with a cardiovascular mesoderm programming cocktail suitable for inducing the hPSCs to differentiate to a cardiovascular mesoderm cell population under conditions suitable for the programming cocktail to penetrate the hPSCs and culturing the contacted hPSCs for a period of time to generate a KDR+ and PDGFRalpha+ cardiovascular mesoderm cell population; (b) contacting the cardiovascular mesoderm cell population with a cardiovascular progenitor specification cocktail suitable to specify a NKX2-5+ or WT1+ cardiovascular progenitor cell population under conditions suitable for the specification cocktail to penetrate the cardiovascular mesoderm cell population and culturing the contacted cardiovascular mesoderm cell population for a period of time to generate a NKX2-5+ or WT1+ cardiovascular progenitor cell population; and (d) contacting the cardiovascular progenitor cell population with a maturation cocktail under conditions suitable for the maturation cocktail to penetrate the cardiovascular progenitor cell population and culturing the contacted cardiovascular progenitor population for a period of time to produce a cardiovascular population optionally cardiomyocyte lineage cells expressing cardiac troponin T (cTnT) and/or SIRPA and/or epicardial lineage cells expressing WT1.
Abstract translation: 提供从hPSC获得心血管谱系细胞的方法和产品。 用于从人多能干细胞（hPSC）获得心肌细胞谱系或心外膜谱系细胞群的方法包括一个或多个以下步骤：（a）使BMP组分引发的hPSC与适合诱导hPSC的心血管中胚层编程混合物接触 在适合编程混合物的条件下分化为心血管中胚层细胞群体以渗透hPSC并培养接触的hPSC一段时间以产生KDR +和PDGFRα+心血管中胚层细胞群; （b）使心血管中胚层细胞群体与适合于规范混合液以渗透心血管中胚层细胞群体并培养接触的心血管中胚层细胞的条件下，适用于指定NKX2-5 +或WT1 +心血管祖细胞群的心血管祖细胞规格混合物接触 人口一段时间以产生NKX2-5 +或WT1 +心血管祖细胞群体; 和（d）在适合于成熟混合物的条件下将心血管祖细胞群与成熟混合物接触以渗透心血管祖细胞群体并培养接触的心血管祖细胞群体一段时间以产生心血管群体，任选地表达心肌细胞谱系细胞 心肌肌钙蛋白T（cTnT）和/或表达WT1的SIRPA和/或心外膜谱系细胞。
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公开(公告)号：US09395364B2
公开(公告)日：2016-07-19
申请号：US14764492
申请日：2014-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Florence Wing Ling Tsui , Robert Davies Inman
IPC: G01N33/53 , G01N33/564 , G06F19/00
CPC classification number: G01N33/564 , G01N33/6854 , G01N33/6893 , G01N2333/4703 , G01N2333/4704 , G01N2800/065 , G01N2800/10 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G06F19/00 , G16H50/30 , Y02A90/26
Abstract: There is provided herein a method for categorizing a patient having inflammatory bowel disease as being at risk for developing ankylosing spondylitis. The method comprises the use of a patient level of auto-antibodies directed against noggin (NOG) and/or sclerostin (SOST) to determine a risk for the patient developing ankylosing spondylitis. There is also provided methods of monitoring ankylosing spondylitis treatment using these auto-antibodies.
Abstract translation: 本文提供了将具有炎症性肠病的患者分类为具有发展为强直性脊柱炎的风险的方法。 该方法包括使用针对头蛋白（NOG）和/或硬皮蛋白（SOST）的患者水平的自身抗体来确定患者发展为强直性脊柱炎的风险。 还提供了使用这些自身抗体监测强直性脊柱炎治疗的方法。
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Patent Agency Ranking
公开(公告)号：US09393326B2
公开(公告)日：2016-07-19
申请号：US14205670
申请日：2014-03-12
Applicant: University Health Network
Inventor： David Jaffray , Christine Allen , Jinzi Zheng , Raymond Matthew Reilly , Gregory Jason Perkins
IPC: A61K49/00 , A61K51/00 , A61K49/04 , A61B5/00 , A61B6/00 , A61B8/08 , A61K9/127 , A61K49/18 , A61K51/12 , A61B5/055 , A61B8/00
CPC classification number: A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
Abstract: There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
Abstract translation: 提供了用于医学成像的信号调节组合物，其包含对两种或多种成像模态特异的载体和信号调节剂。 所述组合物的特征在于保留效率，关于信号调节剂，其能够延长对比成像，而不会从载体中显着消耗信号调节剂。 本发明的载体是基于脂质或聚合物的，其物理化学性质可被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。
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公开(公告)号：US20160180695A1
公开(公告)日：2016-06-23
申请号：US14911067
申请日：2014-08-12
Applicant: UNIVERSITY HEALTH NETWORK
IPC: G08B21/24
CPC classification number: G08B21/245 , G07C9/00111
Abstract: Disclosed herein are different embodiments of a hand hygiene compliance system, beacon, wearable monitor and kit.
Abstract translation: 本文公开了手卫生一致性系统，信标，可穿戴式监视器和套件的不同实施例。
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108.发明申请BIOPSY DEVICE AND METHOD FOR OBTAINING A TOMOGRAM OF A TISSUE VOLUME USING SAME 审中-公开用于获得组织体积的TOMOGRAM的BIOPSY装置和方法公开(公告)号：US20160151055A1
公开(公告)日：2016-06-02
申请号：US14906065
申请日：2014-07-25
Applicant: THE ROYAL INSTITUTION FOR THE ADVACEMENT OF LEARNING/MCGILL UNIVERSITY , UNIVERSITY HEALTH NETWORK , POLYVALOR, LIMITED PARTNERSHIP
Inventor： Frederic LEBLOND , Brian WILSON , Andreanne GOYETTE , Julien PICHETTE , Kevin PETRECCA , Caroline BOUDOUX , Wendy-Julie MADORE , Mathias STRUPLER
IPC: A61B10/04 , A61B10/02 , A61B5/1455 , A61B5/145 , A61B1/07 , A61B5/1459
CPC classification number: A61B10/04 , A61B1/07 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/14546 , A61B5/14556 , A61B5/1459 , A61B10/0275 , A61B10/0283 , A61B2010/045
Abstract: The biopsy device generally comprises: a cannula body having a longitudinal axis and a probing region extending along the longitudinal axis, the probing region having a sample receiving window defined therein for receiving a sample of a surrounding tissue when performing a biopsy; and a plurality of optical fibers mounted along an exterior portion of the cannula body, each of the plurality of optical fibers having a fiber end in the probing region of the cannula body, at least one of the plurality of optical fibers being adapted to illuminate the surrounding tissue with an optical signal generated by the at least one light generator and at least one of the plurality of optical fibers being adapted to detect an optical signal response with the at least one light detector, the optical signal response being caused by the propagation of the optical signal in the surrounding tissue.
Abstract translation: 活检装置通常包括：具有纵向轴线和沿着纵向轴线延伸的探测区域的套管主体，探测区域具有限定在其中的样本接收窗口，用于在进行活检时接收周围组织的样本; 以及沿着所述套管主体的外部部分安装的多个光纤，所述多个光纤中的每一个在所述套管主体的探测区域中具有光纤端，所述多个光纤中的至少一个适于照亮所述光纤 具有由所述至少一个光发生器产生的光学信号的周围组织，并且所述多个光纤中的至少一个适于利用所述至少一个光检测器检测光信号响应，所述光信号响应是由所述至少一个光发射器的传播引起的 周围组织中的光信号。
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公开(公告)号：US20160061832A1
公开(公告)日：2016-03-03
申请号：US14764492
申请日：2014-01-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Florence Wing Ling Tsui , Robert Davies Inman
IPC: G01N33/564 , G06F19/00
CPC classification number: G01N33/564 , G01N33/6854 , G01N33/6893 , G01N2333/4703 , G01N2333/4704 , G01N2800/065 , G01N2800/10 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G06F19/00 , G16H50/30 , Y02A90/26
Abstract: There is provided herein a method for categorizing a patient having inflammatory bowel disease as being at risk for developing ankylosing spondylitis. The method comprises the use of a patient level of auto-antibodies directed against noggin (NOG) and/or sclerostin (SOST) to determine a risk for the patient developing ankylosing spondylitis. There is also provided methods of monitoring ankylosing spondylitis treatment using these auto-antibodies.
Abstract translation: 本文提供了将具有炎症性肠病的患者分类为具有发展为强直性脊柱炎的风险的方法。 该方法包括使用针对头蛋白（NOG）和/或硬皮蛋白（SOST）的患者水平的自身抗体来确定患者发展为强直性脊柱炎的风险。 还提供了使用这些自身抗体监测强直性脊柱炎治疗的方法。
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110.发明授权Functional electrical stimulation method, use and apparatus for mood alteration 有权功能电刺激方法，心情改变的使用和装置公开(公告)号：US09259576B2
公开(公告)日：2016-02-16
申请号：US14204829
申请日：2014-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Milos R. Popovic , Jose Zariffa , Sander L. Hitzig
CPC classification number: A61N1/36096 , A61N1/0452 , A61N1/0504
Abstract: A method and apparatus for providing functional electrical stimulation to an individual for altering a mood or emotional parameter associated with a mood or emotional state is provided. The method involves providing functional electrical stimulation to facial muscles of the individual so as to elicit a detectable contraction in said muscles associated with a facial expression associated with a desired mood or emotional parameter.
Abstract translation: 提供了一种用于向个人提供功能性电刺激以改变与情绪或情绪状态相关联的情绪或情绪参数的方法和装置。 该方法涉及对个体的面部肌肉提供功能性电刺激，从而在与期望的情绪或情绪参数相关联的面部表情相关联的所述肌肉中引发可检测的收缩。
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