公开(公告)号：US20160068650A1

公开(公告)日：2016-03-10

申请号：US14888334

申请日：2014-05-02

Applicant: NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Hai Minh Duong ,  Beng Chye Vincent Tan ,  Truong Son Nguyen ,  Shao Kai NG

IPC: C08J9/28 ,  B01J20/24 ,  B01J20/32 ,  B01J20/30 ,  E04B1/88 ,  C08J9/36 ,  B01J20/28

CPC classification number: C08J9/28 ,  B01J20/24 ,  B01J20/28047 ,  B01J20/28085 ,  B01J20/3085 ,  B01J20/3214 ,  C08J3/075 ,  C08J3/16 ,  C08J9/365 ,  C08J2201/036 ,  C08J2201/0484 ,  C08J2205/026 ,  C08J2205/044 ,  C08J2205/05 ,  C08J2301/02 ,  E04B1/88 ,  E04B2001/746

Abstract: A polysaccharide based aerogel comprising a network of polysaccharide fibers with pores therebetween, wherein the sizes of the pores are in the micrometer range.

Abstract translation: 一种多糖基气凝胶，其包含在其间具有孔隙的多糖纤维网络，其中孔的尺寸在微米范围内。

公开(公告)号：US20160051726A1

公开(公告)日：2016-02-25

申请号：US14403396

申请日：2013-05-16

Applicant: QUEEN'S UNIVERSITY AT KINGSTON

Inventor： Lauren E. Flynn ,  Claire Yu

IPC: A61L27/24 ,  A61L27/26 ,  A61L27/38 ,  A61L27/56 ,  A61L27/54

CPC classification number: A61L27/24 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/64 ,  A61L2430/34 ,  B32B5/32 ,  C08H1/06 ,  C08J9/228 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2389/06 ,  C08L89/06

Abstract: Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibres. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads. The foam materials may be used in applications such as bioscaffolds for wound healing, soft tissue regeneration and augmentation, for localized cell delivery, or as cell culture substrates for research. The foam materials include natural collagen fibrils that provide a stable scaffold and enhance integration of the implanted scaffold and regeneration of cells and tissue.

Abstract translation: 提供了一种泡沫材料，其包含多个基本上胶原的珠粒，其中泡沫材料是珠泡沫，并且其中相邻的胶原珠粒通过胶原纤维网络融合在一起。 还提供了制备泡沫材料的方法，所述泡沫材料包括多个基本上胶原的珠粒。 泡沫材料可以用于例如用于伤口愈合的生物支架，软组织再生和增强，用于局部细胞递送或用作研究的细胞培养底物。 泡沫材料包括天然胶原原纤维，其提供稳定的支架并增强植入的支架的整合以及细胞和组织的再生。

公开(公告)号：US20150361144A1

公开(公告)日：2015-12-17

申请号：US14764463

申请日：2014-04-18

Applicant: SPIBER INC.

Inventor： Toshiaki OSAWA ,  Keisuke MORITA

IPC: C07K14/435 ,  C11B9/00 ,  A61Q19/00 ,  B01J20/24 ,  A61K47/42 ,  A61K8/98

CPC classification number: C07K14/43518 ,  A61K8/0279 ,  A61K8/42 ,  A61K8/46 ,  A61K8/64 ,  A61K8/987 ,  A61K9/19 ,  A61K47/42 ,  A61K2800/10 ,  A61K2800/56 ,  A61K2800/84 ,  A61Q19/00 ,  B01J20/24 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2201/0544 ,  C08J2205/022 ,  C08J2205/028 ,  C08J2389/00 ,  C08L89/00 ,  C11B9/00

Abstract: A polypeptide porous body of the present invention is a porous body of a polypeptide derived from spider silk proteins. The polypeptide includes a water-insoluble polypeptide. The polypeptide porous body has an apparent density of 0.1 g/cm3 or less. A method for producing the polypeptide porous body includes: a solution production step in which the polypeptide is dissolved in at least one solvent selected from DMSO, DMF, and these with an inorganic salt, so as to obtain a solution of the polypeptide; a step in which the solution produced in the solution production step is substituted with a water-soluble solvent so as to obtain a polypeptide gel; and a step in which the polypeptide gel is dried. Thereby, the present invention provides a polypeptide porous body having excellent water absorbability and a polypeptide porous body suitable for application to a living body, and a method for producing the same.

Abstract translation: 本发明的多肽多孔体是衍生自蜘蛛丝蛋白的多肽的多孔体。 多肽包括水不溶性多肽。 多孔多孔体的表观密度为0.1g / cm 3以下。 制备多孔多孔体的方法包括：溶液制备步骤，其中将多肽溶解在至少一种选自DMSO，DMF的溶剂中，并用无机盐溶解，得到多肽的溶液; 在溶液制备工序中产生的溶液用水溶性溶剂代替以获得多肽凝胶的步骤; 以及其中多肽凝胶被干燥的步骤。 因此，本发明提供了具有优异的吸水性的多孔多孔体和适用于生物体的多孔多孔体及其制造方法。

公开(公告)号：US09028857B2

公开(公告)日：2015-05-12

申请号：US12681676

申请日：2008-10-10

Applicant: Catherine Le Visage ,  Didier Letourneur ,  Frederic Chaubet ,  Aude Autissier

Inventor： Catherine Le Visage ,  Didier Letourneur ,  Frederic Chaubet ,  Aude Autissier

IPC: A61F13/00 ,  C07H1/00 ,  C08B37/02 ,  A61L27/20 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L27/56 ,  C12N5/00 ,  C08B37/00 ,  C08B37/08 ,  C08H1/06 ,  C08J9/28

CPC classification number: A61L27/56 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/21 ,  A61L2430/02 ,  A61L2430/06 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08H1/06 ,  C08J3/24 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2205/04 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/08 ,  C08J2305/12 ,  C12N5/0068 ,  C12N11/10 ,  C12N2533/70 ,  Y10T436/147777

Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).

Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备含有至少一种多糖和一种交联剂的碱性水溶液b）冷冻步骤a）的水溶液c）升华步骤b的冷冻溶液 ）。 其特征在于步骤b）在多糖的交联发生在步骤a）的溶液中之前进行。

公开(公告)号：US20140134415A1

公开(公告)日：2014-05-15

申请号：US14077103

申请日：2013-11-11

Applicant: The United States of America as Represented by the Secretary of Agriculture ,  Wisconsin Alumni Research Foundation

Inventor： Shaoqin GONG ,  Alireza JAVADI ,  Qifeng ZHENG ,  Zhiyong CAI ,  Ronald SABO

IPC: C08J9/00 ,  C08J9/28

CPC classification number: C08J9/28 ,  C08J9/0076 ,  C08J2201/0484 ,  C08J2205/026 ,  C08J2300/14

Abstract: Highly porous, lightweight, and sustainable hybrid organic aerogels with ultra-low densities and excellent material properties and methods for preparing them are provided, including, e.g., PVA/CNF/GONS, RF/CNF/GONS, and PVA/CNF/MWCNT. The aerogels are modified to have a super-hydrophobic surface, thus leading to an extremely low swelling ratio and rate of moisture absorption.

Abstract translation: 提供了具有超低密度和优异材料性质的高度多孔，轻质和可持续的混合有机气凝胶及其制备方法，包括例如PVA / CNF / GONS，RF / CNF / GONS和PVA / CNF / MWCNT。 气凝胶被改性为具有超疏水表面，因此导致非常低的溶胀比和吸湿率。

公开(公告)号：US08696955B2

公开(公告)日：2014-04-15

申请号：US12627963

申请日：2009-11-30

Applicant: Younan Xia ,  Sang Hyuk Im ,  Unyong Jeong

Inventor： Younan Xia ,  Sang Hyuk Im ,  Unyong Jeong

IPC: A61K9/50

CPC classification number: C08J3/12 ,  C08F6/14 ,  C08F112/08 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2325/04 ,  C08J2333/12 ,  Y10T428/2998 ,  C08L25/06 ,  C08F2/18

Abstract: A method for making a hollow polymer particle having a single, substantially circular opening in its surface.

Abstract translation: 一种制造中空聚合物颗粒的方法，所述中空聚合物颗粒在其表面具有单个基本圆形的开口

公开(公告)号：US08536317B2

公开(公告)日：2013-09-17

申请号：US12929075

申请日：2010-12-29

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: C07H5/04 ,  C08B37/00 ,  C08B37/10 ,  C07H5/06 ,  C07H1/00

CPC classification number: C08J9/28 ,  C08B11/12 ,  C08B11/20 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08F28/06 ,  C08F251/00 ,  C08F251/02 ,  C08J2201/0484 ,  C08J2305/00 ,  C08L5/00 ,  C08L51/02 ,  Y10T428/249953

Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

Abstract translation: 制备多糖海绵的方法包括以下步骤：（A）冷冻光反应性多糖溶液，和（B）用光照射冷冻的光反应性多糖溶液以交联光反应性多糖，从而获得多糖海绵。 该方法包括不需要除去溶剂的简化步骤，并且具有容易从其中除去杂质的优点。

公开(公告)号：US20130224467A1

公开(公告)日：2013-08-29

申请号：US13819680

申请日：2011-08-16

Applicant: Akira Hirao ,  Kohei Doi ,  Azusa Iseki ,  Yusuke Nakayama ,  Kunio Nagasaki

Inventor： Akira Hirao ,  Kohei Doi ,  Azusa Iseki ,  Yusuke Nakayama ,  Kunio Nagasaki

IPC: C08G18/28

CPC classification number: C08G18/28 ,  B32B5/022 ,  B32B5/024 ,  B32B5/18 ,  B32B5/20 ,  B32B27/40 ,  B32B2255/00 ,  B32B2255/02 ,  B32B2255/06 ,  B32B2255/10 ,  B32B2260/021 ,  B32B2260/046 ,  B32B2266/0207 ,  B32B2266/0214 ,  B32B2266/0278 ,  B32B2307/50 ,  B32B2307/54 ,  C08F2/32 ,  C08F290/067 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/4854 ,  C08G18/672 ,  C08G18/755 ,  C08G18/757 ,  C08G2101/00 ,  C08G2101/0066 ,  C08G2340/00 ,  C08G2350/00 ,  C08J9/0023 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2205/04 ,  C08J2205/05 ,  C08J2375/04 ,  Y10T428/249921 ,  C08L75/16 ,  C08G18/48

Abstract: Provided are a novel foam which has a uniform fine-cell structure and is excellent in toughness and heat resistance, and a production method therefor. Also provided is a functional foam which includes the above-mentioned foam and has imparted thereto various functions. The foam includes spherical cells, in which: the spherical cells each have an average pore diameter of less than 20 μm; the foam has a density of 0.15 g/cm3 to 0.9 g/cm3; and the foam is crack-free in a 180° bending test. The functional foam includes the foam.

Abstract translation: 提供具有均匀的细胞结构并且韧性和耐热性优异的新型泡沫及其制造方法。 还提供了包括上述泡沫体并赋予其各种功能的功能泡沫体。 泡沫包括球形细胞，其中：球形细胞的平均孔径小于20μm; 该泡沫体的密度为0.15g / cm 3至0.9g / cm 3; 并且在180°弯曲试验中，泡沫是无裂纹的。 功能泡沫包括泡沫。

公开(公告)号：US20130005945A1

公开(公告)日：2013-01-03

申请号：US13611339

申请日：2012-09-12

Applicant: Zhilian Yue ,  Feng Wen ,  Hanry Yu

Inventor： Zhilian Yue ,  Feng Wen ,  Hanry Yu

IPC: C08B11/20 ,  B01J19/12 ,  C07K17/12

CPC classification number: B32B3/26 ,  A61L27/20 ,  A61L27/56 ,  C08B11/20 ,  C08J9/28 ,  C08J2201/024 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0524 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2301/28 ,  C08L1/14 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T428/249979 ,  C08L1/28

Abstract: Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.

Abstract translation: 脚手架包含限定大孔的聚合物，并且包含部分由包含自交联基团的取代基取代的羟丙基纤维素，所述取代基通过自交联基团交联。 大孔具有大于50微米的平均孔径并且至少部分互连。 在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。 聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。 在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。 聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

公开(公告)号：US08283028B2

公开(公告)日：2012-10-09

申请号：US12824105

申请日：2010-06-25

Applicant: Zhilian Yue ,  Feng Wen ,  Hanry Yu

Inventor： Zhilian Yue ,  Feng Wen ,  Hanry Yu

IPC: B32B3/26 ,  C08B15/10

CPC classification number: B32B3/26 ,  A61L27/20 ,  A61L27/56 ,  C08B11/20 ,  C08J9/28 ,  C08J2201/024 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0524 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2301/28 ,  C08L1/14 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T428/249979 ,  C08L1/28

Abstract: Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.

Abstract translation: 脚手架包含限定大孔的聚合物，并且包含部分由包含自交联基团的取代基取代的羟丙基纤维素，所述取代基通过自交联基团交联。 大孔具有大于50微米的平均孔径并且至少部分互连。 在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。 聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。 在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。 聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。