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公开(公告)号：US20180221132A1
公开(公告)日：2018-08-09
申请号：US15747815
申请日：2016-08-02
Applicant: GUNZE LIMITED
Inventor： Hidetaka NAKAYAMA , Kosuke SAWAI , Toshiharu SHINOKA , Shuhei TARA , Hirotsugu KUROBE
CPC classification number: A61F2/06 , A61L27/507 , A61L27/56 , A61L27/58 , C08J9/28 , C08J2201/0484 , C08J2201/0522 , C08J2205/022 , C08J2205/024 , C08J2205/044 , C08J2207/10 , C08J2300/16 , C08J2367/04
Abstract: The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.
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2.发明申请公开(公告)号：US20180215892A1
公开(公告)日：2018-08-02
申请号：US15747281
申请日：2016-07-27
Applicant: CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONALE DE LA SANTE ETDE LA RECHERCHE MEDICALE , UNIVERSITE TOULOUSE III - Paul Sabatier
Inventor： Sophie GIROD FULLANA , Brigitte SALLERIN , Raya BUSHKALOVA , Caroline CECCALDI
CPC classification number: C08J9/28 , A61L27/20 , A61L27/26 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/64 , A61L2400/08 , A61L2430/20 , C08J9/0061 , C08J9/08 , C08J2201/026 , C08J2201/0484 , C08J2201/0546 , C08J2203/02 , C08J2205/044 , C08J2205/05 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2405/00 , C08J2405/04 , C08J2405/08 , C08L5/08 , C08L5/04
Abstract: The present invention relates to a process for preparing a biocompatible and biodegradable, porous three-dimensional polymer matrix, to the porous polymer matrix obtained by means of such a process, and also to the uses thereof, in particular as a support and for cell culture or in regenerative medicine, and in particular for cell therapy, in particular cardiac cell therapy.
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公开(公告)号：US09555164B2
公开(公告)日：2017-01-31
申请号：US14708996
申请日：2015-05-11
Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite Paris 7—Denis Diderot
Inventor： Catherine Le Visage , Didier Letourneur , Frederic Chaubet , Aude Autissier
IPC: A61L27/20 , A61L27/50 , A61L27/56 , C08B37/08 , A61F13/00 , A61L27/38 , A61L27/52 , C12N5/00 , C08B37/00 , C08B37/02 , C08H1/06 , C08J9/28 , A61L27/54 , C08J3/24 , C12N11/10
CPC classification number: A61L27/56 , A61L27/20 , A61L27/3804 , A61L27/3826 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/507 , A61L27/52 , A61L27/54 , A61L2300/21 , A61L2430/02 , A61L2430/06 , C08B37/0018 , C08B37/0021 , C08B37/003 , C08B37/0039 , C08B37/0054 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/24 , C08J9/28 , C08J2201/026 , C08J2201/0484 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/02 , C08J2305/08 , C08J2305/12 , C12N5/0068 , C12N11/10 , C12N2533/70 , Y10T436/147777
Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备含有至少一种多糖和一种交联剂的碱性水溶液b）冷冻步骤a）的水溶液c）升华步骤b的冷冻溶液 ），其特征在于步骤b）在多糖的交联发生在步骤a）的溶液中之前进行。
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公开(公告)号：US09328211B2
公开(公告)日：2016-05-03
申请号：US14403541
申请日：2013-05-15
Applicant: Hokuetsu Kishu Paper Co., Ltd. , The University of Tokyo
Inventor： Junji Nemoto , Toshihiko Soyama , Akira Isogai , Tsuguyuki Saito
CPC classification number: C08J9/28 , C08B15/04 , C08J2201/0484 , C08J2301/02 , C08L1/02 , D21H11/20 , F26B5/06 , Y10T428/249965
Abstract: A porous body that contains cellulose nanofibers having very thin fiber diameters and high hydrophilicity, and has a large specific surface area, and to provide a method of producing the porous body simply with low cost. A method of producing a porous cellulose comprises a process of lyophilizing a mixed liquid containing cellulose nanofibers and a dispersion medium, wherein the dispersion medium is a mixed dispersion medium of water and an organic solvent dissolving in water, a concentration of the organic solvent in the mixed dispersion medium is 2 to 40 mass %, and a solid content concentration of the cellulose nanofibers in the mixed liquid is 0.001 to 5 mass %.
Abstract translation: 一种多孔体，其含有纤维直径非常小，亲水性高，纤维素纳米纤维比表面积大的多孔体，简单地提供低成本地制造多孔体的方法。 多孔性纤维素的制造方法包括将含有纤维素纳米纤维和分散介质的混合液冷冻干燥的方法，其中分散介质是水和溶于水的有机溶剂的混合分散介质，其中有机溶剂的浓度在 混合分散介质为2〜40质量％，混合液中的纤维素纳米纤维的固体成分浓度为0.001〜5质量％。
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公开(公告)号：US09328135B2
公开(公告)日：2016-05-03
申请号：US13735975
申请日：2013-01-07
Inventor： Kazutoshi Kobayashi , Naosuke Sumi , Tsuyoshi Abe , Yasushi Tamada
IPC: C07K1/02 , C07K14/435
CPC classification number: C07K1/02 , C07K14/43586 , C08J9/28 , C08J2201/0484 , C08J2389/00
Abstract: A method for producing a porous silk fibroin material, containing steps of: freezing a silk fibroin solution containing a silk fibroin aqueous solution having an aliphatic carboxylic acid added thereto; and then melting the frozen solution, thereby providing a porous material. A method for producing a porous silk fibroin material having excellent mechanical characteristics may be provided.
Abstract translation: 一种生产多孔丝素蛋白材料的方法，包括以下步骤：冷冻含有添加了脂肪族羧酸的丝素蛋白水溶液的丝素蛋白溶液; 然后熔化冷冻溶液，从而提供多孔材料。 可以提供具有优异的机械特性的多孔丝素蛋白材料的制造方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150299415A1
公开(公告)日：2015-10-22
申请号：US14418599
申请日：2013-08-02
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Stephen Michael KENNEDY , Sidi Ahmed BENCHERIF , David J. MOONEY
CPC classification number: C08J9/286 , A61K9/0009 , A61K9/06 , C08F220/06 , C08F220/56 , C08F2222/1013 , C08J9/28 , C08J2201/0484 , C08J2205/022 , C08J2207/10 , C08J2333/02 , C08J2333/26 , C08J2343/00 , C08J2347/00
Abstract: The invention provides cryogels whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electrical stimulus. The cryogels have interconnected macropores which greatly enhance their ability to rapidly undergo volumetric collapse when subjected to moderate electric fields. The cryogels of the invention can be easily integrated into arrays capable of rapid configurational and chromatic optical modulations, and when loaded with drugs, are able to coordinate the delivery profile of multiple drugs. The cryogel can be prepared by polymerizing an aqueous solution of charged monomers and cross-linker monomers at a temperature below the freezing temperature of the solvent.
Abstract translation: 本发明提供了冷冻凝胶，其孔隙率，孔径，孔连通性，溶胀剂浓度和/或比体积响应于电刺激而经历从第一值到第二值的变化。 冷冻凝胶具有相互连接的大孔，当其受到中等电场的影响时，它们能够迅速地发生体积崩溃的能力。 本发明的冷冻凝胶可以容易地集成到能够进行快速配置和彩色光学调制的阵列中，并且当装载有药物时，能够协调多种药物的递送特征。 可以在低于溶剂冷冻温度的温度下聚合带电荷单体和交联剂单体的水溶液来制备冷冻凝胶。
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公开(公告)号：US20140329993A1
公开(公告)日：2014-11-06
申请号：US14334345
申请日：2014-07-17
Applicant: Warsaw Orthopedic, Inc.
Inventor： Nels Lauritzen , Lawrence a. Shimp , Brent S. Mitchell
IPC: C07K14/78
CPC classification number: C07K14/78 , A61K9/0021 , A61K9/122 , A61K47/42 , A61L17/08 , A61L27/24 , A61L27/56 , C08J9/28 , C08J2201/0484 , C08J2389/00
Abstract: Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.
Abstract translation: 泡沫形成的胶原链和用于形成链的方法包括将具有保留量的其天然成分的分离的清除，脱脂，酶处理（或非酶处理）的人源胶原产品的分散溶液沉积在 开槽板，并处理分散的胶原产品以提供泡沫形成的胶原链。 泡沫形成的胶原链可以被加工成具有网状孔基质的丝线，以在该链中进行生物材料，该胶原链的胶原包含分离的，经酶处理的人源胶原，其具有保留量的其天然胶原成分 。
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8.发明授权Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration 有权可降解的亲水嵌段共聚物具有改善的生物相容性，用于软组织再生公开(公告)号：US08877223B2
公开(公告)日：2014-11-04
申请号：US12224891
申请日：2007-03-07
Applicant: Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
Inventor： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
IPC: A61F2/00 , A61K9/14 , B32B5/14 , C12N5/00 , C12N5/02 , C08L67/00 , C08G63/91 , C08G63/664 , A61L15/26 , A61L15/42 , A61L27/18 , A61L27/56
CPC classification number: C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O—(CHR1CHR2O)n—B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [—(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
Abstract translation: 本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长的用途。 聚合物具有式AO-（CHR1CHR2O）n-B，其中A是聚（丙交酯 - 共 - 乙交酯）残基，（i）丙交酯单元[-CH（CH 3）-COO-]和（ii ）乙交酯单元[-CH2-COO-]在80:20至10:90的范围内，B是聚（丙交酯 - 共 - 乙交酯）残基或氢， C 1-6 - 烷基或羟基保护基，R 1和R 2之一为氢或甲基，另一个为氢，n为10-1000，（iii）聚亚烷基二醇单元[ - （CHR1CHR2O） - ] - 聚（丙交酯 - 共 - 乙交酯）残基中（i）丙交酯单元和（ii）乙交酯单元的总量最多为14:86，共聚物的分子量为至少20,000g / mol。
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9.发明申请公开(公告)号：US20130217127A1
公开(公告)日：2013-08-22
申请号：US13880020
申请日：2011-08-08
Applicant: Ashok Kumar
Inventor： Ashok Kumar
CPC classification number: C08F16/06 , C08F20/00 , C08F220/34 , C08J9/0061 , C08J9/28 , C08J2201/0484 , C08J2205/022 , C08J2205/026 , C08J2333/04 , C08J2333/24 , C08J2343/00 , C08J2405/00 , C08J2429/04 , C08L29/04 , C12N5/0068 , C12N5/0602 , C12N2533/30 , C08L33/26
Abstract: A cryogel contains a polyol and a co-polymer of Formula (I).
Abstract translation: 冷冻凝胶含有多元醇和式（I）的共聚物。
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公开(公告)号：US20130197193A1
公开(公告)日：2013-08-01
申请号：US13735975
申请日：2013-01-07
Applicant: Kazutoshi KOBAYASHI , Naosuke SUMI , Tsuyoshi ABE , Yasushi TAMADA
Inventor： Kazutoshi KOBAYASHI , Naosuke SUMI , Tsuyoshi ABE , Yasushi TAMADA
IPC: C07K1/02
CPC classification number: C07K1/02 , C07K14/43586 , C08J9/28 , C08J2201/0484 , C08J2389/00
Abstract: A method for producing a porous silk fibroin material, containing steps of: freezing a silk fibroin solution containing a silk fibroin aqueous solution having an aliphatic carboxylic acid added thereto; and then melting the frozen solution, thereby providing a porous material. A method for producing a porous silk fibroin material having excellent mechanical characteristics may be provided.
Abstract translation: 一种生产多孔丝素蛋白材料的方法，包括以下步骤：冷冻含有添加了脂肪族羧酸的丝素蛋白水溶液的丝素蛋白溶液; 然后熔化冷冻溶液，从而提供多孔材料。 可以提供具有优异的机械特性的多孔丝素蛋白材料的制造方法。
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