Solvent-assisted loading of therapeutic agents
    101.
    发明授权
    Solvent-assisted loading of therapeutic agents 有权
    溶剂辅助加载治疗剂

    公开(公告)号:US08158151B2

    公开(公告)日:2012-04-17

    申请号:US10915274

    申请日:2004-08-10

    Inventor: James G. Hansen

    CPC classification number: A61L27/54 A61L31/16 A61L2300/416 A61L2300/42

    Abstract: Methods are provided for loading polymeric regions of medical devices with therapeutic agents. In these methods, a polymeric region of a medical device is first pretreated with a solvent system. Subsequently, therapeutic-agent-containing particles are impacted into the pretreated polymeric region at a velocity that is effective to at least partially embed the particles within the pretreated polymeric region. The pretreatment step parameters (e.g., the particular solvent system employed, amount of time that the solvent system contacts the polymeric region, etc.) are typically selected such that the surface tack of the polymeric region is increased. Consequently, the depth, the amount, or both the depth and the amount of the particles that become at least partially embedded in the polymeric region is/are typically increased, relative to what would be achieved in the absence of the pretreatment step. Also provided are medical devices made by such methods.

    Abstract translation: 提供了用于加载具有治疗剂的医疗装置的聚合物区域的方法。 在这些方法中,医疗装置的聚合物区域首先用溶剂系统预处理。 随后,含有治疗剂的颗粒以有效至少部分地将颗粒嵌入预处理的聚合物区域内的速度冲击到预处理的聚合物区域中。 通常选择预处理步骤参数(例如,所用的具体溶剂体系,溶剂体系与聚合物区域接触的时间量等),使得聚合物区域的表面粘性增加。 因此,相对于在没有预处理步骤的情况下,将成为至少部分地嵌入聚合物区域中的颗粒的深度,数量或深度和量都通常增加。 还提供了通过这种方法制造的医疗装置。

    Composition and method for a thermal coating system
    102.
    发明授权
    Composition and method for a thermal coating system 有权
    热涂层系统的组成和方法

    公开(公告)号:US08147922B2

    公开(公告)日:2012-04-03

    申请号:US12562527

    申请日:2009-09-18

    Abstract: A thermal coating includes a substrate, a first coating layer, and a second coating layer. The substrate is selected from the group consisting of superalloys and ceramic matrix composites. The first coating layer comprises an alumina powder, a silica binder, and at least one additive selected from either a first group or a second group. The second coating layer comprises at least one of zinc titanate or cerium oxide. A method for applying a thermal coating system includes spraying a bond coat mixture onto a substrate using a liquid electrostatic sprayer. The bond coat mixture comprises an alumina powder, a silica binder, and at least one additive selected from either a first group or a second group. The method further includes applying a top coat mixture onto the bond coat mixture, wherein the top coat mixture comprises at least one of zinc titanate or cerium oxide.

    Abstract translation: 热涂层包括基底,第一涂层和第二涂层。 基材选自超级合金和陶瓷基复合材料。 第一涂层包含氧化铝粉末,二氧化硅粘合剂和至少一种选自第一组或第二组的添加剂。 第二涂层包含钛酸锌或氧化铈中的至少一种。 施加热涂覆系统的方法包括使用液体静电喷涂器将粘合涂层混合物喷涂到基底上。 粘合涂层混合物包含氧化铝粉末,二氧化硅粘合剂和至少一种选自第一组或第二组的添加剂。 该方法还包括将面漆混合物施加到粘合涂层混合物上,其中顶涂层混合物包含钛酸锌或氧化铈中的至少一种。

    METHOD FOR CONTROLLING A COEFFICIENT OF FRICTION
    104.
    发明申请
    METHOD FOR CONTROLLING A COEFFICIENT OF FRICTION 有权
    控制摩擦系数的方法

    公开(公告)号:US20110287986A1

    公开(公告)日:2011-11-24

    申请号:US12784467

    申请日:2010-05-20

    Abstract: A method for controlling a coefficient of friction involves applying a magnetic force, an electro-magnetic force, and/or an electrostatic force to nanoparticles disposed on a surface. The method further involves controlling a rolling-to-sliding ratio of the nanoparticles on the surface by i) adjusting a value of the force applied to the nanoparticles, and/or ii) adjusting an orientation of the nanoparticles by adjusting a direction of the force applied to the nanoparticles.

    Abstract translation: 用于控制摩擦系数的方法包括向设置在表面上的纳米颗粒施加磁力,电磁力和/或静电力。 该方法还包括通过以下步骤来控制纳米颗粒在表面上的滚动 - 滑动比:i)调节施加到纳米颗粒的力的值,和/或ii)通过调节力的方向来调节纳米颗粒的取向 应用于纳米颗粒。

    Electrostatic lubricant dispensing system
    107.
    发明授权
    Electrostatic lubricant dispensing system 有权
    静电润滑剂分配系统

    公开(公告)号:US07935390B2

    公开(公告)日:2011-05-03

    申请号:US12162742

    申请日:2007-02-02

    Abstract: A lubricant dispensing system is provided. The dispensing system includes a lubricant supply, a lubricant dispensing nozzle and a control panel. The dispensing nozzle includes a nozzle body with a fluid passageway therein which is in fluid communication with the lubricant supply, an electrode assembly for electrostatically charging lubricant in the fluid passageway and at least one discharge orifice through which electrostatically charged lubricant can be discharged. The discharge orifice is defined by at least one spray needle having a first end in fluid communication with the fluid passageway and a second end that extends outward of the nozzle body. The control panel directs the flow of lubricant from the lubricant supply to the lubricant dispensing nozzle and controls the electric power supplied to the electrode assembly.

    Abstract translation: 提供润滑剂分配系统。 分配系统包括润滑剂供应,润滑剂分配喷嘴和控制面板。 分配喷嘴包括喷嘴主体,其中具有与润滑剂供应源流体连通的流体通道,用于在流体通道中静电充填润滑剂的电极组件和至少一个可以排出静电荷润滑剂的排出孔。 排放孔由至少一个喷射针限定,其具有与流体通道流体连通的第一端和从喷嘴体向外延伸的第二端。 控制面板将来自润滑剂供给的润滑剂的流动引导到润滑剂分配喷嘴,并控制提供给电极组件的电力。

    METHOD FOR FORMING ARTIFICIAL LIPID MEMBRANE
    108.
    发明申请
    METHOD FOR FORMING ARTIFICIAL LIPID MEMBRANE 有权
    形成人造脂膜的方法

    公开(公告)号:US20110083793A1

    公开(公告)日:2011-04-14

    申请号:US12971885

    申请日:2010-12-17

    CPC classification number: G01N33/48728

    Abstract: An object of the present invention is to provide a method for stably forming an artificial lipid membrane while suppressing the leakage and evaporation of an electrolytic solution.The present invention is an artificial lipid membrane forming method for forming an artificial lipid membrane using an artificial lipid membrane forming apparatus. The artificial lipid membrane forming apparatus comprises a first chamber, a second chamber, a dividing wall, and an artificial lipid membrane forming portion. Each of the first chamber and the second chamber has a capacity of not smaller than 10 pl and not larger than 200 μl. The artificial lipid membrane forming method of the present invention comprises the steps of: preparing the artificial lipid membrane forming apparatus; adding to the first chamber a first electrolytic solution having a viscosity of not lower than 1.3 mPa·s and not higher than 200 mPa·s; adding a lipid solution to the artificial lipid membrane forming portion; adding to the second chamber a second electrolytic solution having a viscosity of not lower than 1.3 mPa·s and not higher than 200 mPa·s; and forming the artificial lipid membrane.

    Abstract translation: 本发明的目的是提供一种在抑制电解液的泄漏和蒸发的同时稳定地形成人造脂膜的方法。 本发明是使用人造脂质膜形成装置形成人造脂质膜的人造脂质膜形成方法。 人造脂膜形成装置包括第一室,第二室,分隔壁和人造脂膜形成部。 第一室和第二室中的每一个具有不小于10pl且不大于200μl的容量。 本发明的人造脂膜形成方法包括以下步骤:制备人造脂膜形成装置; 向第一室中加入粘度不低于1.3mPa·s且不高于200mPa·s的第一电解液; 向人造脂膜形成部分添加脂质溶液; 向第二室中加入粘度不低于1.3mPa·s且不高于200mPa·s的第二电解液; 并形成人造脂膜。

    Paper coating slip based on pigment-polymer hybrids
    110.
    发明授权
    Paper coating slip based on pigment-polymer hybrids 有权
    基于颜料 - 聚合物杂化物的纸涂层滑移

    公开(公告)号:US07858154B2

    公开(公告)日:2010-12-28

    申请号:US11719219

    申请日:2005-11-05

    CPC classification number: D21H19/58 D21H19/42 Y10T428/31895

    Abstract: A paper coating slip comprising at least one inorganic pigment and, based on 100 parts by weight of the inorganic pigments, less than 40 parts by weight of organic polymers, and less than 25 parts by weight of water or other solvents having a boiling point below 150° C. at 1 bar.

    Abstract translation: 包含至少一种无机颜料的纸涂层滑爽剂,基于100重量份的无机颜料,少于40重量份的有机聚合物和小于25重量份的沸点低于25重量份的水或其它溶剂 150℃,1巴。

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