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公开(公告)号：US11780580B2
公开(公告)日：2023-10-10
申请号：US17067397
申请日：2020-10-09
Applicant: California Institute of Technology
Inventor： Jacob S. Izraelevitz , Brett A. Kennedy , Amanda R. Bouman , Daniel Pastor Moreno , Matthew James Lindsay Anderson , Paul M. Nadan , Joel W. Burdick
CPC classification number: B64C39/024 , B64C1/30 , B64U10/13 , B64U30/12 , B64U30/20 , B64U50/19 , B64U70/00
Abstract: A ballistically launched foldable multirotor vehicle has a central body frame. A battery is located in an upper vertical location of the vehicle and positions a center of mass of the vehicle to provide aerodynamic stability during a launch. Fins are attached to the central body frame such that aerodynamic forces on the fins shift an aerodynamic center (AC) of the vehicle downward below the center of mass of the vehicle. Three or more foldable arms are attached to the central body frame via a hinge and exist in two states—a closed state where the foldable arms are parallel to a central body axis, and an open state (after launch) where the foldable arms extend radially outward perpendicular to the central body axis. Rotors mounted to each foldable arm are controlled by a motor to enable flight.
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公开(公告)号：US20230313245A1
公开(公告)日：2023-10-05
申请号：US17985033
申请日：2022-11-10
Applicant: California Institute of Technology
Inventor： Patrick J. Almhjell , Frances H. Arnold
CPC classification number: C12P13/225 , C12Y402/0102 , C12N9/88
Abstract: The present disclosure provides engineered enzymes and methods for preparing tyrosine and tyrosine analogs from a donor amino acid and phenols in a single step. Also disclosed are methods to engineer enzymes having such ‘tyrosine synthase’ activity, starting from the beta-subunit of a tryptophan synthase (TrpB).
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公开(公告)号：US11772826B2
公开(公告)日：2023-10-03
申请号：US16670941
申请日：2019-10-31
Applicant: California Institute of Technology
Inventor： Sergio Pellegrino , Eleftherios E. Gdoutos , Antonio Pedivellano
IPC: B64G1/22
CPC classification number: B64G1/222
Abstract: An actively controlled deployment mechanism with a plurality of centrally controlled rollers as well as outer rollers that are configured to apply a pressure across the compactable portion of the deployable structure. The active control can be implemented though control motors and control loops programed to control the rotation of the rollers. Additionally, the actively controlled deployment reduces the need for bulky and heavy booms with high tension guide wires for the deployment of the structure.
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公开(公告)号：US20230279082A1
公开(公告)日：2023-09-07
申请号：US18297301
申请日：2023-04-07
Inventor： Hugo Mouquet , Michel Nussenzweig , Pamela J. Bjorkman , Louise Scharf
CPC classification number: C07K16/1045 , C07K16/1063 , A61K39/42 , C07K2317/565 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92 , C12N2740/16111 , A61K45/06
Abstract: The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies. Since its discovery in 1981, HIV type 1 (HIV-1) has led to the death of at least 25 million people worldwide.
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公开(公告)号：US20230274177A1
公开(公告)日：2023-08-31
申请号：US18175378
申请日：2023-02-27
Applicant: California Institute of Technology
Inventor： Manuel Endres , Adam L. Shaw , Soonwon Choi , Daniel K. Mark , Joonhee Choi
Abstract: Systems and methods for generating random quantum states or benchmarking quantum machines.
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Patent Agency Ranking
公开(公告)号：US20230272466A1
公开(公告)日：2023-08-31
申请号：US17863183
申请日：2022-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. ISMAGILOV , Jacob T. BARLOW , Said R. BOGATYREV
IPC: C12Q1/686 , C12Q1/6888
CPC classification number: C12Q1/686 , C12Q1/6888
Abstract: Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure.
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公开(公告)号：US11731196B2
公开(公告)日：2023-08-22
申请号：US17394881
申请日：2021-08-05
Applicant: California Institute of Technology
Inventor： Samad A. Firdosy , Robert P. Dillon , Nicholas E. Ury , Katherine Dang , Joshua Berman , Pablo Narvaez , Vilupanur A. Ravi , John Paul Castelo Borgonia , Joelle T. Cooperrider , Bryan W. McEnerney , Andrew A. Shapiro-Scharlotta
CPC classification number: B22F7/02 , B22F3/15 , B22F10/28 , B22F10/64 , B33Y10/00 , B33Y40/20 , B33Y80/00 , H05K9/0081 , B22F2301/35 , B22F2304/10 , Y10T29/49002
Abstract: Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters.
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公开(公告)号：US11730376B2
公开(公告)日：2023-08-22
申请号：US16896976
申请日：2020-06-09
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Niema M. Pahlevan
CPC classification number: A61B5/02028 , A61B5/0006 , A61B5/021 , A61B5/0285 , A61B5/02233 , A61B5/318 , A61B7/00
Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.
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119.发明授权公开(公告)号：US11719705B2
公开(公告)日：2023-08-08
申请号：US16010347
申请日：2018-06-15
Applicant: Indi Molecular, Inc. , California Institute of Technology
Inventor： Heather Agnew , Bert Tsunyin Lai , Suresh Mark Pitram , Blake Farrow , James R. Heath , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das
CPC classification number: G01N33/6869 , C07K7/06 , C07K14/54
Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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公开(公告)号：US11719576B2
公开(公告)日：2023-08-08
申请号：US17083165
申请日：2020-10-28
Applicant: California Institute of Technology
Inventor： William R Johnson , Matthew E Kenyon , Jordana Blacksberg , Carol A Raymond , Bethany L Ehlmann , Xiangwen Chen
CPC classification number: G01J3/2803 , B64G1/66 , G01J3/021 , G01J3/0286 , G01J3/18 , G01J5/12 , G02B23/06 , G01J2003/2813
Abstract: Methods and devices to implement mid-wave and long-wave infrared point spectrometers are disclosed. The described methods and devices involve bi-faceted gratings, high-operating-temperature barrier infrared and thermal detectors. The disclosed concept can be used to design flight spectrometers that cover broad solar reflectance plus thermal emission spectral ranges with a compact and low-cost instrument suitable for small spacecraft reconnaissance of asteroids, the Moon, and planetary satellites as well as mass-constrained landed missions.
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