公开(公告)号：US08222399B2

公开(公告)日：2012-07-17

申请号：US11162597

申请日：2005-09-15

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: C08B37/08 ,  A61K31/728 ,  C12N5/02

CPC classification number: A61L31/042 ,  A61K31/738 ,  A61K31/74 ,  A61L27/20 ,  C08B11/12 ,  C08B37/0006 ,  C08B37/0009 ,  C08B37/003 ,  C08B37/0036 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0045 ,  C08B37/006 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08J3/075 ,  C08J2201/0484 ,  C08J2305/08 ,  C08L1/286 ,  C08L5/04 ,  C08L5/08 ,  C08L5/10

Abstract: A photoreactive polysaccharide which comprises a polysaccharide bound to a glycidyl ester via a covalent bond, a photocrosslinked-polysaccharide prepared by using the photoreactive polysaccharide, and medical products comprising the photocrosslinked-polysaccharide.

Abstract translation: 包含通过共价键与缩水甘油酯结合的多糖的光反应性多糖，使用所述光反应性多糖制备的光交联多糖和包含所述光交联多糖的医药品。

公开(公告)号：US07951936B2

公开(公告)日：2011-05-31

申请号：US11976810

申请日：2007-10-29

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: C07H1/00 ,  C07H5/06 ,  C08B11/12 ,  A61K31/715 ,  A61K31/727 ,  A61K31/70 ,  A01N43/04

CPC classification number: C08J9/28 ,  C08B11/12 ,  C08B11/20 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08F28/06 ,  C08F251/00 ,  C08F251/02 ,  C08J2201/0484 ,  C08J2305/00 ,  C08L5/00 ,  C08L51/02 ,  Y10T428/249953

Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

公开(公告)号：US20100247598A1

公开(公告)日：2010-09-30

申请号：US12415260

申请日：2009-03-31

Applicant: Dhanuraj S. Shetty ,  Iksoo Chun ,  Murty N. Vyakamam ,  Thomas Patrick Hyland

Inventor： Dhanuraj S. Shetty ,  Iksoo Chun ,  Murty N. Vyakamam ,  Thomas Patrick Hyland

IPC: A61F2/02 ,  C08J9/28 ,  A61K47/34 ,  B26D3/00

CPC classification number: C08J9/26 ,  A61L15/26 ,  A61L15/425 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2207/10 ,  C08J2367/04 ,  Y10T83/04 ,  C08L67/04

Abstract: A novel method of manufacturing thick foams, especially molded thick foams useful as tissue scaffolds and other medical devices. Also disclosed are novel thick foams made using the process of the present invention, wherein such thick foams may be used as medical devices or components of medical devices.

Abstract translation: 一种制造厚泡沫的新方法，特别是用作组织支架和其它医疗装置的模制厚泡沫。 还公开了使用本发明的方法制备的新型厚泡沫，其中这种厚的泡沫可以用作医疗装置的医疗装置或部件。

公开(公告)号：US20100221303A1

公开(公告)日：2010-09-02

申请号：US12681682

申请日：2008-10-10

Applicant: Catherine Le Visage ,  Didier Letourneur

Inventor： Catherine Le Visage ,  Didier Letourneur

IPC: A61K9/00 ,  B28B1/14 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0735 ,  C12N5/10 ,  C12N1/00 ,  A61K35/12 ,  A61K35/66 ,  C12Q1/02 ,  C12N1/16 ,  C12N1/19 ,  C12N5/04 ,  A61P43/00

CPC classification number: A61L27/20 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08J9/08 ,  C08J9/28 ,  C08J9/283 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/04 ,  C08J2305/08 ,  C08J2305/10 ,  C08J2305/12 ,  C12N5/0068 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74

Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备包含一定量的多糖，一定量的交联剂和一定量的致孔剂的碱性水溶液b）将溶液转化成水凝胶 通过将所述溶液置于约4℃至约80℃的温度下足够的时间以允许所述量的多糖的交联和c）将所述水凝胶浸入水溶液中d）洗涤多孔支架 在步骤c）获得。

公开(公告)号：US20080166385A1

公开(公告)日：2008-07-10

申请号：US11630305

申请日：2005-07-29

Applicant: Timothy D. Durance ,  Jaya Sundaram ,  Mareike Ressing

Inventor： Timothy D. Durance ,  Jaya Sundaram ,  Mareike Ressing

IPC: A01N25/16 ,  C08J9/228 ,  A01P3/00 ,  A01P15/00 ,  A61K9/12

CPC classification number: C08J9/28 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2301/00 ,  F26B5/048 ,  F26B5/06

Abstract: A method for producing foams, such as sponges, from hydrocolloids is described. A solid or semi-solid gel is formed by dissolving polymeric material in an aqueous solvent. The gel formed is allowed to set, and may optionally then be cut into the desired shape. The gel may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the gel is exposed to a radiant energy field for drying under vacuum. This causes the solvent to boil and the foam or sponge is formed. Medicinally active ingredients may be included in the process, so that the sponge or foam formed contains the active ingredient dispersed within the structure. The method described provides an alternative to the conventional methods of particulate leaching or freeze drying.

Abstract translation: 描述了从水胶体生产泡沫如海绵的方法。 通过将聚合物材料溶解在水性溶剂中形成固体或半固体凝胶。 允许形成的凝胶固化，然后可任选地切割成所需的形状。 凝胶可以被冷冻以允许形成冰晶作为致孔剂。 随后，将凝胶暴露于辐射能场以在真空下干燥。 这使得溶剂沸腾并形成泡沫或海绵。 药物活性成分可以包括在该方法中，使得形成的海绵或泡沫包含分散在结构内的活性成分。 所述方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

公开(公告)号：US20080071001A1

公开(公告)日：2008-03-20

申请号：US11976810

申请日：2007-10-29

Applicant: Tomoya Sato

Inventor： Tomoya Sato

IPC: C08F2/46

CPC classification number: C08J9/28 ,  C08B11/12 ,  C08B11/20 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08F28/06 ,  C08F251/00 ,  C08F251/02 ,  C08J2201/0484 ,  C08J2305/00 ,  C08L5/00 ,  C08L51/02 ,  Y10T428/249953

Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

Abstract translation: 制备多糖海绵的方法包括以下步骤：（A）冷冻光反应性多糖溶液，和（B）用光照射冷冻的光反应性多糖溶液以交联光反应性多糖，从而获得多糖海绵。 该方法包括不需要除去溶剂的简化步骤，并且具有容易从其中除去杂质的优点。

公开(公告)号：US20070225388A1

公开(公告)日：2007-09-27

申请号：US10587734

申请日：2004-12-23

Applicant: Andrew Cooper ,  Alison Foster ,  Steven Rannard ,  Haifei Zhang

Inventor： Andrew Cooper ,  Alison Foster ,  Steven Rannard ,  Haifei Zhang

IPC: C08J9/28 ,  C08J9/16

CPC classification number: C08J9/28 ,  C08J2201/0484 ,  C08J2205/05 ,  C08J2300/14

Abstract: Water dispersible or water soluble porous bodies comprising a three dimensional open-cell lattice containing (a) 10 to 95% by weight of a water soluble polymeric material and (b) 5 to 90% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry of at least about 3 ml/g with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm

Abstract translation: 水分散性或水溶性多孔体，其包含三维开孔格子，其包含（a）10至95重量％的水溶性聚合物材料和（b）5-90重量％的表面活性剂，所述多孔体具有 通过水银孔隙率法测量的入渗体积至少约3ml / g，条件是所述多孔体不是平均珠粒直径为0.2至5mm的球形珠粒

公开(公告)号：US20040076811A1

公开(公告)日：2004-04-22

申请号：US10470349

申请日：2003-10-15

Inventor： Tomoya Sato

IPC: B32B003/26

CPC classification number: C08J9/28 ,  C08B11/12 ,  C08B11/20 ,  C08B15/005 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08F28/06 ,  C08F251/00 ,  C08F251/02 ,  C08J2201/0484 ,  C08J2305/00 ,  C08L5/00 ,  C08L51/02 ,  Y10T428/249953

Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.

Abstract translation: 制备多糖海绵的方法包括以下步骤：（A）冷冻光反应性多糖溶液，和（B）用光照射冷冻的光反应性多糖溶液以交联光反应性多糖，从而获得多糖海绵。 该方法包括不需要除去溶剂的简化步骤，并且具有容易从其中除去杂质的优点。

公开(公告)号：US20030077455A1

公开(公告)日：2003-04-24

申请号：US10134262

申请日：2002-04-29

Applicant: ATOFINA Chemicals, Inc.

Inventor： Ramin Amin-Sanayei ,  Lawrence K. Wempe ,  Kurt Arthur Wood ,  Stefano Finocchiaro ,  Delphine Tillier

IPC: B05B003/00 ,  B29C035/02 ,  B05D003/02

CPC classification number: B29C67/202 ,  B05D5/083 ,  C03C17/006 ,  C03C17/32 ,  C04B41/4842 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2205/05 ,  C23C30/00 ,  Y10T428/2973 ,  Y10T428/31544

Abstract: Processes for the preparation of adherent polyvinylidene fluoride, hexafluoropropylene coatings on objects and for the direct production of open celled foams from a polymer latex without a need for any blowing agent.

Abstract translation: 用于在物体上制备粘附的聚偏二氟乙烯，六氟丙烯涂层以及用于从聚合物胶乳直接生产开孔泡沫而不需要任何发泡剂的方法。

公开(公告)号：US20020058718A1

公开(公告)日：2002-05-16

申请号：US09939838

申请日：2001-08-27

Applicant: The Regents of the University of Michigan

Inventor： Peter X. Ma ,  Ruiyun Zhang

IPC: C08J009/26

CPC classification number: C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/00 ,  C12N5/0068 ,  C12N2533/12 ,  C12N2533/18 ,  C12N2533/30 ,  C12N2533/40 ,  G01N15/14

Abstract: Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.

Abstract translation: 描述了提供三维多孔基质作为细胞结构模板的方法和组合物。 本发明的多孔基质具有适合于各种应用的理想的机械性能，包括用于体外细胞培养的平台，用于组织和器官工程的植入物，以及适用于色谱和过滤的材料。