公开(公告)号：US5709886A

公开(公告)日：1998-01-20

申请号：US802147

申请日：1997-02-19

Applicant: Marie Jean Bettman ,  Phillip J. Percel ,  Thomas C. Powell

Inventor： Marie Jean Bettman ,  Phillip J. Percel ,  Thomas C. Powell

IPC: A61K9/00 ,  A61K9/46 ,  B01J13/08

CPC classification number: A61K9/0056 ,  A61K9/0007 ,  Y10T428/2989

Abstract: Taste masked effervescent microcapsules are provided each microcapsule containing an effervescent admixture of sodium bicarbonate and citric acid microencapsulated with ethylcellulose, the effervescent microcapsules being useful in formulating taste masked effervescent chewable tablets also containing microencapsulated, unpleasant tasting drugs such as non-steroidal, anti-inflammatory, NSAID drugs.

Abstract translation: 提供口味掩蔽的泡腾微胶囊，每个微胶囊含有用乙基纤维素微胶囊化的碳酸氢钠和柠檬酸的泡腾混合物，泡腾微胶囊可用于配制掩味的泡腾咀嚼片，其还含有微囊化的令人不快的品尝药物，例如非甾体，抗炎 ，NSAID药物。

公开(公告)号：US5690869A

公开(公告)日：1997-11-25

申请号：US537665

申请日：1995-10-05

Applicant: Rudolf Hinterwaldner ,  Bruno Hertrich ,  Wilfried Babel

Inventor： Rudolf Hinterwaldner ,  Bruno Hertrich ,  Wilfried Babel

IPC: A61K9/50 ,  A61K47/32 ,  B01J13/04 ,  B01J13/06 ,  B01J13/08 ,  B01J13/14 ,  C08F290/00 ,  C08F299/00 ,  C08G18/72 ,  C08G59/18 ,  C08J3/24 ,  C09D101/00 ,  C09D101/08 ,  C09D103/00 ,  C09D105/00 ,  C09D189/00

CPC classification number: B01J13/08 ,  B01J13/14

Abstract: The present invention relates to the use of a polymer material based on modified hydrocolloids as covering material for critical working substances.

Abstract translation: PCT No.PCT / EP95 / 02107 Sec。 371日期1995年10月5日第 102（e）日期1995年10月5日PCT归档1995年6月2日PCT公布。 出版物WO95 / 33554 日期1995年12月14日本发明涉及基于改性水胶体的聚合物材料作为关键作业物质的覆盖材料的用途。

公开(公告)号：US5654008A

公开(公告)日：1997-08-05

申请号：US729277

申请日：1996-10-10

Applicant: Paul F. Herbert ,  Azar M. Hazrati

Inventor： Paul F. Herbert ,  Azar M. Hazrati

IPC: A61K9/50 ,  A61K9/16 ,  A61K31/519 ,  A61K31/568 ,  A61K31/57 ,  A61K47/34 ,  B01J13/02 ,  B01J13/06 ,  B01J13/08

CPC classification number: A61K9/1694 ,  A61K9/1647 ,  B01J13/06 ,  B01J13/08 ,  Y10S977/788 ,  Y10S977/898 ,  Y10S977/90

Abstract: A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.

Abstract translation: 一种制备包含可生物降解的聚合物粘合剂和生物活性剂的可生物降解的微粒的方法。 将包含活性剂和聚合物的第一相和第二相通过静态混合器泵送到骤冷液体中以形成含有活性剂的微粒。 优选地，使用至少两种不含卤代烃的基本上无毒的溶剂的混合物来溶解或分散试剂并溶解聚合物。

公开(公告)号：US5616311A

公开(公告)日：1997-04-01

申请号：US212546

申请日：1994-03-14

Applicant: Richard C. K. Yen

Inventor： Richard C. K. Yen

IPC: A61K9/16 ,  A61K9/51 ,  A61K47/48 ,  A61K51/08 ,  A61K9/50 ,  B01J13/08 ,  C12N11/02

CPC classification number: A61K9/5169 ,  A61K47/488 ,  A61K47/48884 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1658 ,  A61K9/5192 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/797 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/93 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2989

Abstract: Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of hemoglobin in the particle composition. Particles which are primarily hemoglobin in the nanometer and micrometer size range in an aqueous suspension are rendered stable against aggregation by the incorporation of either albumin, surface active agents or gelatin.

Abstract translation: 在水性悬浮液中纳米和微米尺寸范围的白蛋白颗粒在不经过交联剂的帮助下通过将血红蛋白掺入颗粒组合物中而使其稳定，不经过变性。 在水性悬浮液中以纳米和微米尺寸范围为主的血红蛋白的颗粒通过掺入白蛋白，表面活性剂或明胶而变得稳定，防止聚集。

公开(公告)号：US5562924A

公开(公告)日：1996-10-08

申请号：US295886

申请日：1994-09-08

Applicant: Eric Perrier ,  Chantal Buffevant

Inventor： Eric Perrier ,  Chantal Buffevant

IPC: A23L1/00 ,  A23L1/09 ,  A61K8/11 ,  A61K8/67 ,  A61K8/73 ,  A61K8/97 ,  A61K9/16 ,  A61K9/50 ,  A61K47/36 ,  A61Q19/00 ,  B01J13/04 ,  B01J13/14 ,  B01J13/08

CPC classification number: A61K8/11 ,  A61K8/671 ,  A61K8/678 ,  A61K8/73 ,  A61K8/732 ,  A61K8/97 ,  A61K9/1652 ,  A61Q19/00 ,  B01J13/14 ,  A61K2800/412 ,  A61K2800/43

Abstract: The invention concerns the production of polysaccharide wall microcapsules or microspheres containing primary alcohol functions crosslinked by a crosslinking agent. Said microcapsules or microspheres contain an active food, cosmetic or pharmaceutical ingredient and are hence used in the preparation of food, cosmetic or pharmaceutical compositions.

Abstract translation: PCT No.PCT / FR93 / 00237 Sec。 371日期1994年9月8日 102（e）1994年9月8日PCT PCT 1993年3月10日PCT公布。 公开号WO93 / 17784 日期1993年9月16日本发明涉及含有通过交联剂交联的伯醇官能团的多糖壁微胶囊或微球体的生产。 所述微胶囊或微球含有活性食品，化妆品或药物成分，因此用于制备食品，化妆品或药物组合物。

公开(公告)号：US5040960A

公开(公告)日：1991-08-20

申请号：US280939

申请日：1988-12-07

Applicant: Toshiaki Shioya ,  Yasuhiko Shiinoki

Inventor： Toshiaki Shioya ,  Yasuhiko Shiinoki

IPC: C12N5/00 ,  A23L1/00 ,  A23L1/06 ,  A23L1/24 ,  A23L2/00 ,  A23P1/04 ,  A61K9/66 ,  B01J13/04 ,  B01J13/08 ,  B01J13/14 ,  C12N5/06 ,  C12N11/04

CPC classification number: C12N11/04 ,  A23L2/00 ,  A23P10/30 ,  A23P20/105 ,  B01J13/04 ,  B01J13/08 ,  Y10S426/803

Abstract: An apparatus for the production of encapsulated bodies employing a dropping tank for a fluid to form the cores of the encapsulated bodies and a reaction tank containing a solution capable of forming gel skins upon contact with the core material in communication therewith. Double-walled cylindrical nozzles are arranged in a lower part of the drop tank, the inner and outer walls of the double-walled cylindrical nozzles being coaxial. A pressurized air feed pipe is in communication with an upper part of the dropping tank. The peripheral walls of the reaction tank are in the form of a double-walled cylinder whose upper peripheral portion of its inner wall contains a screen. A liquid feed pipe and a capsule discharge port are provided in communication with the interior of the reaction tank through lower parts of the double-walled cylinder. A liquid discharge port also is provided in communication with an annular spacing of the double-walled cylinder through its outer wall.The apparatus provides for obtaining a dispersion of encapsulated bodies without their mechanical separation from the liquid in which they are prepared.

公开(公告)号：US4795328A

公开(公告)日：1989-01-03

申请号：US88955

申请日：1987-08-24

Applicant: Motoharu Takano

Inventor： Motoharu Takano

IPC: A23L1/24 ,  A23P1/04 ,  B01J2/06 ,  B01J2/18 ,  B01J13/04 ,  B01J13/08 ,  B01J ,  B01J2/08 ,  B29C67/00

CPC classification number: B01J2/06 ,  B01J13/046 ,  B01J13/08 ,  B01J2/18

Abstract: Encapsulation apparatus for forming capsules by dropping a coagulatable mixture into a coagulation tank, including a dropping tank with a perforated bottom and a coagulation tank beneath the dropping tank. The dropping tank has a shallow mid-section and deeper portions at the inlet and discharge ends. Pumps provide circulation between the discharge and inlet ends of the coagulation tank.

公开(公告)号：US4542042A

公开(公告)日：1985-09-17

申请号：US510202

申请日：1983-07-01

Applicant: Masayoshi Samejima ,  Goichi Hirata ,  Takashi Ishibashi

Inventor： Masayoshi Samejima ,  Goichi Hirata ,  Takashi Ishibashi

IPC: A61K9/62 ,  A61K9/50 ,  B01J13/02 ,  B01J13/08 ,  B01J13/12 ,  B05D7/00

CPC classification number: B01J13/08 ,  A61K9/5047 ,  A61K9/5089 ,  B01J13/12 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989

Abstract: A process for preparing free-flowing microcapsules by taking advantage of the phase-separation of ethylcellulose in cyclohexane is disclosed. In this process, a hydrocarbon compound which is soluble in cyclohexane and have a molecular weight of 150 to 3,000 and a solubility parameter (.delta., at 25.degree. C.) of 7 to 10 (cal/cm.sup.3).sup.1/2 is used as the phase-separation-inducing agent.

Abstract translation: 公开了一种通过利用乙基纤维素在环己烷中的相分离来制备自由流动的微胶囊的方法。 在该方法中，使用可溶于环己烷并且分子量为150至3,000且溶解度参数（δ在25℃）为7至10（cal / cm 3）1/2的烃化合物作为 相分离诱导剂。

公开(公告)号：US4443497A

公开(公告)日：1984-04-17

申请号：US333026

申请日：1981-12-21

Applicant: Masayoshi Samejima ,  Goichi Hirata

Inventor： Masayoshi Samejima ,  Goichi Hirata

IPC: A61K9/56 ,  A61K9/16 ,  B01J13/08 ,  B01J13/02

CPC classification number: A61K9/1694 ,  A61K9/1635 ,  A61K9/1652 ,  B01J13/08

Abstract: Microcapsules are prepared by conducting the phase-separation of a coating polymer material in the presence of ethylcellulose. Ethylcellulose present in the phase separation system minimizes the coagulation of the coating polymer material.

Abstract translation: 通过在乙基纤维素存在下进行涂层聚合物材料的相分离来制备微胶囊。 存在于相分离系统中的乙基纤维素使涂层聚合物材料的凝结最小化。

公开(公告)号：US4124526A

公开(公告)日：1978-11-07

申请号：US806219

申请日：1977-06-13

Applicant: Pierre J. Allart ,  Henri B. May

Inventor： Pierre J. Allart ,  Henri B. May

IPC: B01J13/08 ,  B41M5/165 ,  B01J13/02

CPC classification number: B01J13/08 ,  B41M5/165 ,  Y10S428/914 ,  Y10T428/249997 ,  Y10T428/2984 ,  Y10T428/2987

Abstract: Oil droplets are encapsulated by forming a dispersion of the droplets in an aqueous alkaline liquid medium containing a water-soluble salt of a polycarboxylate polymer and acidifying the medium to a pH in the range of 5 to 8 whereby the polycarboxylate polymer precipitates to form walls around the droplets.

Abstract translation: 通过在含有多羧酸盐聚合物的水溶性盐的含水碱性液体介质中形成液滴的分散体并将介质酸化至5至8范围内的pH，从而聚合多羧酸盐聚合物沉淀形成壁 液滴。